Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Nicolas L Young"'
Autor:
Kanishk Jain, Matthew R Marunde, Jonathan M Burg, Susan L Gloor, Faith M Joseph, Karl F Poncha, Zachary B Gillespie, Keli L Rodriguez, Irina K Popova, Nathan W Hall, Anup Vaidya, Sarah A Howard, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Emily F Patteson, Spencer W Cooke, Bethany C Taylor, Ellen N Weinzapfel, Marcus A Cheek, Matthew J Meiners, Geoffrey C Fox, Kevin EW Namitz, Martis W Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S Cosgrove, Nicolas L Young, Michael-Christopher Keogh, Brian D Strahl
Publikováno v:
eLife, Vol 12 (2023)
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylat
Externí odkaz:
https://doaj.org/article/4578fc571e78426c9ad347f2e09aa9c9
Autor:
Yanlin Fan, Yusong R Guo, Wang Yuan, Ying Zhou, Matthew V Holt, Tao Wang, Borries Demeler, Nicolas L Young, Weiwei Zhong, Yizhi J Tao
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006231 (2017)
Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until six years ago. The Orsay virus and its related nematode viruses have a positive-sense RNA genome, encoding
Externí odkaz:
https://doaj.org/article/c20b4743d1fa4641b9107286e422a37c
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181869 (2017)
Aminoacyl-tRNA synthetases-interacting multifunctional protein3 (AIMP3/p18) is involved in the macromolecular tRNA synthetase complex via its interaction with several aminoacyl-tRNA synthetases. Recent reports reveal a novel function of AIMP3 as a tu
Externí odkaz:
https://doaj.org/article/f78d4e016a174f5ca4476423b605f71c
Autor:
Mariana P Torrente, Barry M Zee, Nicolas L Young, Richard C Baliban, Gary LeRoy, Christodoulos A Floudas, Sandra B Hake, Benjamin A Garcia
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24747 (2011)
Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. H
Externí odkaz:
https://doaj.org/article/0322e3e42503460f8febd57583e3c521
Autor:
Margaret Phillips, Kathleen Quinn, Hana Paculova, Cameron Montgomery, Faith M. Joseph, Samuel P. Boyson, Sunsik Chang, Jay C. Nix, Nicolas L. Young, Seth E. Frietze, Karen C. Glass
The ATPase family, AAA domain containing 2B (ATAD2B) protein has a C-terminal bromodomain that functions as a ‘reader’ of acetylated lysine residues on histone proteins. However, the molecular mechanisms by which it recognizes chromatin with mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c006f1d023284ee3ca5219a94ca9bb75
https://doi.org/10.1101/2022.11.14.516501
https://doi.org/10.1101/2022.11.14.516501
Autor:
Richard H. Chapple, Matthew C. Hill, James F. Martin, Angelique Lin, Nicolas L. Young, Matthew V. Holt, Ayumi Kitano, Xiangguo Shi, Tianyuan Hu, Daisuke Nakada, Yu-Jung Tseng, Jonathan F. Tiessen, Kevin A. Hoegenauer, Rebecca Murdaugh
Publikováno v:
Stem Cell Reports
Summary Histone variants contribute to the complexity of the chromatin landscape and play an integral role in defining DNA domains and regulating gene expression. The histone H3 variant H3.3 is incorporated into genic elements independent of DNA repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd959fec037219c8bbe1ff022ae917e8
http://europepmc.org/articles/PMC8365107
http://europepmc.org/articles/PMC8365107
Autor:
Bethany C Taylor, Nicolas L. Young
Publikováno v:
Biochemical Journal. 478:511-532
Histones are essential proteins that package the eukaryotic genome into its physiological state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) of histones are crucial to both the dynamic and persistent regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c5a775f8068bc860d9c9f3065108b0
https://doi.org/10.1042/bcj20200170
https://doi.org/10.1042/bcj20200170
Autor:
Faith M. Joseph, Nicolas L. Young
Publikováno v:
Seminars in celldevelopmental biology. 135
Post-translational modifications (PTMs) of histones play a key role in DNA-based processes and contribute to cell differentiation and gene function by adding an extra layer of regulation. Variations in histone sequences within each family of histones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a1c6c35959b3d3c43c373f76271e66
https://pubmed.ncbi.nlm.nih.gov/35277331
https://pubmed.ncbi.nlm.nih.gov/35277331
Publikováno v:
Journal of the American Society for Mass Spectrometry. 30:2548-2560
Proteins physiologically exist as "proteoforms" that arise from one gene and acquire additional function by post-translational modifications (PTM). When multiple PTMs coexist on single protein molecules, top-down proteomics becomes the only feasible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b611b3322cd8c67d5b7e0afb84053e15
https://doi.org/10.1007/s13361-019-02350-z
https://doi.org/10.1007/s13361-019-02350-z
Autor:
Nicolas L. Young, Sae-Woong Oh, Caleb A. Wood, Jun Li, Joanna L. Jankowsky, Kyung Won Park, Bethany C Taylor
Publikováno v:
Mol Ther
Numerous aggregation inhibitors have been developed with the goal of blocking or reversing toxic amyloid formation in vivo. Previous studies have used short peptide inhibitors targeting different amyloid β (Aβ) amyloidogenic regions to prevent aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c1f6fae879ea1e50e36c8bcada7979
https://europepmc.org/articles/PMC8261072/
https://europepmc.org/articles/PMC8261072/