Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicolas J. Roth"'
Autor:
Elena Tomas Bort, Megan D Joseph, Qiaoying Wang, Edward P Carter, Nicolas J Roth, Jessica Gibson, Ariana Samadi, Hemant M Kocher, Sabrina Simoncelli, Peter J McCormick, Richard P Grose
Publikováno v:
eLife, Vol 12 (2023)
Pancreatic ductal adenocarcinoma (PDAC) continues to show no improvement in survival rates. One aspect of PDAC is elevated ATP levels, pointing to the purinergic axis as a potential attractive therapeutic target. Mediated in part by highly druggable
Externí odkaz:
https://doaj.org/article/ace7a2bc4e9d4b73a47134cc59514c93
Autor:
Elena Tomas Bort, Megan D Joseph, Qiaoying Wang, Edward P Carter, Nicolas J Roth, Jessica Gibson, Ariana Samadi, Hemant M Kocher, Sabrina Simoncelli, Peter J McCormick, Richard P Grose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a70d3d0bfb74162566fd76cbe1cbe50
https://doi.org/10.7554/elife.86971.sa2
https://doi.org/10.7554/elife.86971.sa2
Autor:
Elena Tomas Bort, Megan D. Joseph, Qiaoying Wang, Edward P. Carter, Nicolas J. Roth, Jessica Gibson, Ariana Samadi, Hemant M. Kocher, Sabrina Simoncelli, Peter J. McCormick, Richard P. Grose
Pancreatic ductal adenocarcinoma (PDAC) is a cancer of unmet clinical need. Given the elevated ATP levels seen in PDAC, the purinergic axis represents an attractive therapeutic target. Mediated in part by highly druggable extracellular proteins, it p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bebb4e9c69b9b0cc5e34edcf6c975af
https://doi.org/10.1101/2022.10.24.513477
https://doi.org/10.1101/2022.10.24.513477
Autor:
Yoav Peleg, Amandeep Kaur Gill, Peter J. McCormick, Masha Y. Niv, Vidicha Chunilal, Joaquin Botta, Nicolas J. Roth, Vadivel Prabahar, Hadar Israeli, Li F. Chan, Moran Shalev-Benami, Oksana Degtjarik, Fabrizio Fierro, Danny Ben-Zvi
Publikováno v:
Science. 372:808-814
To eat or not to eat Melanocortin receptor 4 (MC4R) plays a role in regulating food intake: Its activation by a stimulating hormone inhibits appetite, whereas binding to a natural antagonist promotes appetite. Complementing a recent structure of MC4R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f092d0ca7414c5995b19e816c9c473c7
https://doi.org/10.1126/science.abf7958
https://doi.org/10.1126/science.abf7958
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity
Autor:
Emily L. Relton, Nicolas J. Roth, Seda Yasa, Abuzar Kaleem, Guido Hermey, Christopher J. Minnis, Sara E. Mole, Tatyana Shelkovnikova, Stephane Lefrancois, Peter J. McCormick, Nicolas Locker
Publikováno v:
Journal of Biological Chemistry. 299:104649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ebac2b96625591a4a42035c785b922
https://doi.org/10.1016/j.jbc.2023.104649
https://doi.org/10.1016/j.jbc.2023.104649
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity
Autor:
Emily L. Relton, Nicolas J. Roth, Seda Yasa, Abuzar Kaleem, Guido Hermey, Stephane Lefrancois, Peter J. McCormick, Nicolas Locker
The assembly of membrane-less organelles such as stress granules (SGs) is emerging as central in helping cells rapidly respond and adapt to stress. Following stress sensing, the resulting global translational shutoff leads to the condensation of stal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed33682083daa19d7d22202b97fee15
https://doi.org/10.1101/2022.05.20.492784
https://doi.org/10.1101/2022.05.20.492784
Autor:
Natasha L. Grimsey, Dmitry B. Veprintsev, Roman C. Sarott, Teresa Grande, Patrick Pfaff, Jürg Gertsch, Pal Pacher, Erick M. Carreira, Christoph Ullmer, Hermon Asmelash, Pattarin Hompluem, Svenja Moes, Daniela Holzer, Catarina Raposo, William R. Drobyski, Sylwia Huber, Jennifer Beck, Uwe Grether, Marc Nazaré, Claudia Korn, Zoltán Varga, Eline J. Koers, Jacopo Piovesan, Irene Benito-Cuesta, Klaus Gawrisch, Matthias Westphal, Benjamin Brennecke, Gabriella Widmer, Yurii Saroz, Eric Kusznir, Tom van der Wel, Anto Pavlovic, Kenneth Atz, Man C Vong, Tamara Miljuš, Peter J. McCormick, Mauro Maccarrone, Harpreet Mandhair, Samuel Ruiz de Martín Esteban, Sergio Oddi, Yelena Mostinski, Julián Romero, Elisabeth A. Zirwes, Anja Osterwald, Jürgen Fingerle, Cecilia J. Hillard, David A. Sykes, Alexei Yeliseev, Faye M. Drawnel, Mario van der Stelt, Marie Weise, Arne C. Rufer, Cheng-Yin Yuan, Thais Gazzi, Nicolas J. Roth, Michael Honer, Wolfgang Guba
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, 142(40), 16953-16964
Journal of the American Chemical Society, 142(40), 16953-16964
Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite the significance of this receptor, researchers l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1774cb215365081fabff5fd4b151b22f
http://hdl.handle.net/11697/158602
http://hdl.handle.net/11697/158602
Autor:
Faye M. Drawnel, Mauro Maccarrone, Catarina Raposo, Peter J. McCormick, Jürgen Fingerle, Cecilia J. Hillard, Svenja Moes, Marc Nazaré, Sergio Oddi, Natasha L. Grimsey, David A. Sykes, Marie Weise, Sylwia Huber, Matthias Westphal, Yurii Saroz, William R. Drobyski, Anto Pavlovic, Gabriella Widmer, Patrick Pfaff, Dmitry B. Veprintsev, Benjamin Brennecke, Kenneth Atz, Anja Osterwald, Erick M. Carreira, Grether U, Julián Romero, Yelena Mostinski, Yuan C, Christoph Ullmer, Hermon Asmelash, Pattarin Hompluem, Gazzi, Thais, Tamara Miljuš, Daniela Holzer, Alexei Yeliseev, Roman C. Sarott, Stelt Mvd, Wel Tvd, Arne C. Rufer, Harpreet Mandhair, Claudia Korn, Elisabeth A. Zirwes, Zoltán Varga, Irene Benito-Cuesta, Jennifer Beck, Klaus Gawrisch, Teresa Grande, Nicolas J. Roth, Michael Honer, Wolfgang Guba, Vong M, Jürg Gertsch, Pal Pacher
Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the treatment of numerous conditions including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite its significance, researchers lack reliable tools
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2488c25f21762f3f55fbde432fa91266
https://doi.org/10.26434/chemrxiv.10288547
https://doi.org/10.26434/chemrxiv.10288547