Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Nicolas J. Guehl"'
Autor:
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [11C]3MeO4AP has shown promise due to
Externí odkaz:
https://doaj.org/article/3d734de69661416e837557c698a2e2cb
Autor:
Felicitas J. Detmer, Nathaniel M. Alpert, Sung-Hyun Moon, Maeva Dhaynaut, J. Luis Guerrero, Nicolas J. Guehl, Fangxu Xing, Pedro Brugarolas, Timothy M. Shoup, Marc D. Normandin, Matthieu Pelletier-Galarneau, Georges El Fakhri, Yoann Petibon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this proof-of-principle study, we investigated whether PET mapping of cardiac membrane potential, an indicator of mitochondrial function, could detect
Externí odkaz:
https://doaj.org/article/45f72c7eae84477dbaf9f917eb1916ed
Autor:
Cinthya Aguero, Maeva Dhaynaut, Marc D. Normandin, Ana C. Amaral, Nicolas J. Guehl, Ramesh Neelamegam, Marta Marquie, Keith A. Johnson, Georges El Fakhri, Matthew P. Frosch, Teresa Gomez-Isla
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract [F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection of Alzheimer disease. We have e
Externí odkaz:
https://doaj.org/article/c17455142d6d417a93810cff5500cd94
Autor:
Jessie Fanglu Fu, Cristina Lois, Justin Sanchez, J Alex Becker, Zoe B Rubinstein, Emma Thibault, Andrew N Salvatore, Hasan Sari, Michelle E Farrell, Nicolas J Guehl, Marc D Normandin, Georges El Fakhri, Keith A Johnson, Julie C Price
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 43:581-594
[18F]MK-6240 meningeal/extracerebral off-target binding may impact tau quantification. We examined the kinetics and longitudinal changes of extracerebral and reference regions. [18F]MK-6240 PET was performed in 24 cognitively-normal and eight cogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0104540a0187219e36f6395fbddb4d3c
https://doi.org/10.1177/0271678x221142139
https://doi.org/10.1177/0271678x221142139
Autor:
Yang Sun, Nicolas J. Guehl, Yu-Peng Zhou, Kazue Takahashi, Vasily Belov, Maeva Dhaynaut, Sung-Hyun Moon, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
ACS Chemical Neuroscience. 13:3342-3351
Demyelination, the loss of the insulating sheath of neurons, causes failed or slowed neuronal conduction and contributes to the neurological symptoms in multiple sclerosis, traumatic brain and spinal cord injuries, stroke, and dementia. In demyelinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fe0e4ee5fd61ebc5118cd85f17f74d
https://doi.org/10.1021/acschemneuro.2c00364
https://doi.org/10.1021/acschemneuro.2c00364
Autor:
Pedro Brugarolas, Moses Q. Wilks, Jacqueline Noel, Julia-Ann Kaiser, Danielle R. Vesper, Karla M. Ramos-Torres, Nicolas J. Guehl, Marina T. Macdonald-Soccorso, Yang Sun, Peter A. Rice, Daniel L. Yokell, Ruth Lim, Marc D. Normandin, Georges El Fakhri
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 50:344-351
Purpose [18F]3F4AP is a novel PET radiotracer that targets voltage-gated potassium (K+) channels and has shown promise for imaging demyelinated lesions in animal models of neurological diseases. This study aimed to evaluate the biodistribution, safet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::504473b055d27badeb665e3a50850be6
https://doi.org/10.1007/s00259-022-05980-w
https://doi.org/10.1007/s00259-022-05980-w
Autor:
Gengyang, Yuan, Maeva, Dhaynaut, Nicolas J, Guehl, Sepideh, Afshar, Dalena, Huynh, Sung-Hyun, Moon, Suhasini M, Iyengar, Manish Kumar, Jain, Julie E, Pickett, Hye Jin, Kang, Mary Jo, Ondrechen, Georges, El Fakhri, Marc D, Normandin, Anna-Liisa, Brownell
Publikováno v:
Journal of medicinal chemistry. 65(14)
An array of triazolopyridines based on JNJ-46356479 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ecf86dcfbee8ecb3de446d4a3dfa7f3
https://pubmed.ncbi.nlm.nih.gov/35802702
https://pubmed.ncbi.nlm.nih.gov/35802702
Autor:
Gengyang Yuan, Maeva Dhaynaut, Nicolas J. Guehl, Sepideh Afshar, Dalena Huynh, Sung-Hyun Moon, Suhasini M. Iyengar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Mary Jo Ondrechen, Georges El Fakhri, Marc D. Normandin, Anna-Liisa Brownell
Publikováno v:
Journal of Medicinal Chemistry. 65:9939-9954
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::718a0a41038b3ae055d0f610dab969ad
https://doi.org/10.1021/acs.jmedchem.2c00593
https://doi.org/10.1021/acs.jmedchem.2c00593
Autor:
Carmen Priolo, Marc D. Normandin, Georges El Fakhri, Marie F. Kijewski, William M. Oldham, Peter M. Sadow, Souheil El-Chemaly, Ye Cui, Walter Massefski, Chongzhao Ran, Nicolas J. Guehl, Jing Yang, Ramesh Neelamegam, Timothy M. Shoup, Shuyan Wang, Kazue Takahashi, You Feng, William J. Mischler, Taylor R. Kavanagh, Eline E. Verwer
[18F]FCH and [18F]FACE-PET images of LAM patient renal angiomyolipoma-derived tumor xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2913947bfbdba7e2d4c60ce9ad5029
https://doi.org/10.1158/1078-0432.22469582.v1
https://doi.org/10.1158/1078-0432.22469582.v1
Autor:
Carmen Priolo, Marc D. Normandin, Georges El Fakhri, Marie F. Kijewski, William M. Oldham, Peter M. Sadow, Souheil El-Chemaly, Ye Cui, Walter Massefski, Chongzhao Ran, Nicolas J. Guehl, Jing Yang, Ramesh Neelamegam, Timothy M. Shoup, Shuyan Wang, Kazue Takahashi, You Feng, William J. Mischler, Taylor R. Kavanagh, Eline E. Verwer
Summary of FCH and FACE Imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44817273faf1d72572e54bea0c0bc6a9
https://doi.org/10.1158/1078-0432.22469561.v1
https://doi.org/10.1158/1078-0432.22469561.v1