A Medical Student-Run Telehealth Primary Care Clinic During the COVID-19 Pandemic: Maintaining Care for the Underserved

Autor: Joshua W. Bliss, Annie Yau, Elena Beideck, Jesse S. S. Novak, Felipe B. d’Andrea, Nicolas J. Blobel, Ashita S. Batavia, Pamela Charney

Publikováno v: Journal of Primary Care & Community Health, Vol 13 (2022)

Background: In this report, we outline our approach to implementing a hybrid in-person and virtual clinic model at a student-run free clinic (SRFC) during the COVID-19 pandemic. Individuals of low socioeconomic status (SES) are at an increased risk f

Externí odkaz: https://doaj.org/article/83789b1e66f441e4b5f06bb3274ba62e

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

Autor: Richard Laga, Robert A. Seder, Hidehiro Yamane, Nicolas J. Blobel, Yaakov Itzkowitz, Eliane Piaggio, Faezzah Baharom, Vincent L. Coble, Leonard W. Seymour, Brennan Decker, Olivier Lantz, Christine Sedlik, Ramiro A. Ramirez-Valdez, Justin Cheung, Joseph R. Francica, Geoffrey M. Lynn, Neeha Zaidi, Yaling Zhu, Sarah R. Nichols, Joshua D. Bernstock, Mateusz Maciejewski, Andrew S. Ishizuka, Joshua M. Gammon, Jordan Denizeau, Brian Francica, Christopher M. Jewell, Philippe De La Rochere, Charles G. Drake, Kennedy Tobin, Margery G. Smelkinson

Publikováno v: Nature Biotechnology
Nature Biotechnology, Nature Publishing Group, 2020, ⟨10.1038/s41587-019-0390-x⟩
Nature biotechnology
Nature Biotechnology, 2020, ⟨10.1038/s41587-019-0390-x⟩
Nature Biotechnology, Nature Publishing Group, 2020, Epub ahead of print. ⟨10.1038/s41587-019-0390-x⟩
Nature Biotechnology, 2020, Epub ahead of print. ⟨10.1038/s41587-019-0390-x⟩

International audience; Personalized cancer vaccines targeting patient-specific neoantigens are a promising cancer treatment modality; however, neoantigen physicochemical variability can present challenges to manufacturing personalized cancer vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644c10d50fa2842221d97056616010fc
https://www.hal.inserm.fr/inserm-02479477/document

Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction

Autor: Anna Lagová, Ramiro A. Ramirez-Valdez, Michael Y. Gerner, Joseph M. Leal, Karel Ulbrich, Faezzah Baharom, Leonard W. Seymour, Amy Wang, Joseph R. Francica, Tomáš Etrych, Gray Kueberuwa, Neeha Zaidi, Andrew S. Ishizuka, Petr Chytil, Richard Laga, Geoffrey M. Lynn, Robert A. Seder, Nicolas J. Blobel

Publikováno v: Biomacromolecules. 20(2)

Small molecule Toll-like receptor-7 and -8 agonists (TLR-7/8a) can be used as vaccine adjuvants to induce CD8 T cell immunity but require formulations that prevent systemic toxicity and focus adjuvant activity in lymphoid tissues. Here, we covalently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2da6e866c5f1cb09624599979da0ff
https://pubmed.ncbi.nlm.nih.gov/30608149

Peptide-based polymer Toll-Like Receptor 7/8 agonist nanoparticles increase the breadth of anti-tumor CD8 T cell immunity

Autor: Andrei Ramirez-Valdez, Nicolas J Blobel, Andrew S Ishizuka, Jenny Pan, Suman Vodnala, Nicholas P Restifo, Geoffrey M Lynn, Robert A Seder

Publikováno v: The Journal of Immunology. 198:73.23-73.23

Targeting tumor specific neoantigens through personalized therapeutic vaccination is a promising approach to induce T cell immunity against a variety of tumors. Current vaccine formulations induce CD8 T cell responses against a limited subset of pre-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93ad28ee2e976e71e17c2271856fc965
https://doi.org/10.4049/jimmunol.198.supp.73.23