Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Nicolas Huber"'
Autor:
Federico Pinna, Michaela Bissinger, Katharina Beuke, Nicolas Huber, Thomas Longerich, Ursula Kummer, Peter Schirmacher, Sven Sahle, Kai Breuhahn
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
In the liver tumor necrosis factor (TNF)-induced signaling critically regulates the immune response of non-parenchymal cells as well as proliferation and apoptosis of hepatocytes via activation of the NF-κB and JNK pathways. Especially, the inductio
Externí odkaz:
https://doaj.org/article/f899ec503a3e4bee82139cb18a71fc4f
Publikováno v:
Haematologica, Vol 100, Iss 10 (2015)
Aplastic anemia is a rare but life-threatening disorder characterized by cytopenia in at least two of the three blood lineages. A frequent feature of patients with aplastic anemia is that they have shorter telomeres than those of age-matched controls
Externí odkaz:
https://doaj.org/article/d1b0795910604d53994f43d4aa1bfeaf
Autor:
Philipp Ernst, Tina M. Schnöder, Nicolas Huber, Florian Perner, Ashok Kumar Jayavelu, Theresa Eifert, Chen-Jen Hsu, Nuria Tubío-Santamaría, Carl C. Crodel, Martin Ungelenk, Christian A. Hübner, Joachim H. Clement, Andreas Hochhaus, Florian H. Heidel
Publikováno v:
Leukemia. 36:1843-1849
Mutations of the JAK2 gene are frequent aberrations in the aging hematopoietic system and in myeloid neoplasms. While JAK-inhibitors efficiently reduce hyperinflammation induced by the constitutively active mutated JAK2 kinase, the malignant clone an
Autor:
Florian Perner, Peter R. Mertens, Andreas Hochhaus, Scott A. Armstrong, Charlie Hatton, Sabine Brandt, Ciara Murphy, Matthias Mann, Nicolas Schröder, Ashok Kumar Jayavelu, Birgit Perner, Tina M. Schnoeder, Yijun Xiong, Anna Mandinova, Kristina Todorova, Jessica I. Hoell, Theresa Eifert, Nicolas Huber, Nomusa Mashamba, Florian H. Heidel, Nuria Tubio Santamaria, Maximilian Hartmann
Publikováno v:
Leukemia
Persistence of malignant clones is a major determinant of adverse outcome in patients with hematologic malignancies. Despite the fact that the majority of patients with acute myeloid leukemia (AML) achieve complete remission after chemotherapy, a lar
Autor:
Bärbel Edelmann-Stephan, Andreas Hochhaus, Sabine Brandt, Nicolas Schröder, Florian Perner, Gurumoorthy Krishnamoorthy, Iain Coldham, Amit U. Sinha, Claudia Waskow, Lars Bullinger, Stefanie Jilg, Philipp J. Jost, Martin Ungelenk, Francesca Palandri, Matthias Mann, Rebecca Austin, Frank Edlich, Tina M. Schnöder, Susann Rahmig, Carolin Herzog, Robert Zeiser, Steven W. Lane, Arno Meiler, Thomas Ernst, Christian A. Hübner, Juliane Mohr, Ashok Kumar Jayavelu, Peter R. Mertens, Nicolas Huber, Florian H. Heidel, Ann Mullally, Berend Isermann
Publikováno v:
Nature
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively
Autor:
Steven W. Lane, Florian Perner, Nicolas Huber, Florian H. Heidel, Elizabeth Ng, Andreas Hochhaus, Edouard G. Stanley, Zhu Chen, Chen-Jen Hsu, Monica Nafria, Ashok Kumar Jayavelu, Lars Bullinger, Lu Jiang, Klaus-Dieter Fischer, Constanze Bonifer, Matthias Mann, Marcus Buschbeck, Steffen Brodt, Holger Bierhoff, Tina M. Schnoeder, Adrian Schwarzer, Sai-Juan Chen, Joanna Kirkpatrick, Georg Matziolis, Olaf Heidenreich, Patricia Arreba-Tutusaus, Theresa Eifert, Björn von Eyss, Chun-Wei Chen, Konstanze Döhner, Andrew G. Elefanty, Anna Dolnik, Yuting Dai, Sophie G Kellaway, Anetta Ptasinska, Salam A. Assi, Alessandro Ori
Publikováno v:
Blood
In an effort to identify novel drugs targeting fusion-oncogene–induced acute myeloid leukemia (AML), we performed high-resolution proteomic analysis. In AML1-ETO (AE)-driven AML, we uncovered a deregulation of phospholipase C (PLC) signaling. We id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc5d880ca55311258241635b370c0f4
http://edoc.mdc-berlin.de/21022/1/21022oa.pdf
http://edoc.mdc-berlin.de/21022/1/21022oa.pdf
Autor:
Sebastián Espinel-Ríos, Nicolas Huber, Edgar Alberto Alcalá-Orozco, Bruno Morabito, Thomas F.T. Rexer, Udo Reichl, Steffen Klamt, Rolf Findeisen
Publikováno v:
IFAC-Papers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44483f7029d3ae65c9be2fc553da6205
https://hdl.handle.net/21.11116/0000-000D-71CC-E21.11116/0000-000D-71CE-C
https://hdl.handle.net/21.11116/0000-000D-71CC-E21.11116/0000-000D-71CE-C
Autor:
Nicolas Huber, Ralf Küsters, Toomas Krips, Julian Liedtke, Johannes Müller, Daniel Rausch, Pascal Reisert, Andreas Vogt
Elections are an important corner stone of democratic processes. In addition to publishing the final result (e.g., the overall winner), elections typically publish the full tally consisting of all (aggregated) individual votes. This causes several is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5e004b75f6f5a8bd787cce9337d353
http://orbilu.uni.lu/handle/10993/52513
http://orbilu.uni.lu/handle/10993/52513
Autor:
Arif Wibowo, Haryono Haryono, Kurniawan Kurniawan, Vitas Atmadi Prakoso, Hadi Dahruddin, Indah Lestari Surbani, Boby Muslimin, Yohanes Yudha P. Jaya, Sudarsono Sudarsono, Ivor G. Stuart, Harald Ahnelt, Simon Funge-Smith, Anti Vasemägi, Nicolas Hubert
Publikováno v:
Global Ecology and Conservation, Vol 49, Iss , Pp e02786- (2024)
The bronze featherback (Notopterus notopterus) is an iconic species of freshwater fish commonly found in South-East Asia and of great commercial and patrimonial importance. At present, the genus Notopterus comprises of two distinct species, Notopteru
Externí odkaz:
https://doaj.org/article/0839c3dfc1f44200b938da27d88e7d28
Publikováno v:
Ecology and Evolution, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract The Beibu Gulf in China is situated in the tropics, in the western Pacific Ocean. It is an emblematic region combining proximity to a marine biodiversity hotspot and a major seafood hub. Intensification of marine fishing and ocean warming le
Externí odkaz:
https://doaj.org/article/2cacff5e35384c1aaca5b6904f9c0cc7