Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nicolas Grillet"'
Autor:
Pei Wang, Katharine K. Miller, Enqi He, Siddhant S. Dhawan, Christopher L. Cunningham, Nicolas Grillet
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Hair cell bundles consist of stereocilia arranged in rows of increasing heights, connected by tip links that transmit sound-induced forces to shorter stereocilia tips. Auditory mechanotransduction channel complexes, composed of proteins TMC1
Externí odkaz:
https://doaj.org/article/6dec91197d6c4a8ab875eb0920892abd
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Electron microscopy paired with immunogold labeling is the most precise tool for protein localization. However, these methods are either cumbersome, resulting in small sample numbers and restricted quantification, or limited to identifying p
Externí odkaz:
https://doaj.org/article/885bf9dc4bb646ccb1e4e3a32bdda29a
Autor:
Tian Wang, Angela H. Ling, Sara E. Billings, Davood K. Hosseini, Yona Vaisbuch, Grace S. Kim, Patrick J. Atkinson, Zahra N. Sayyid, Ksenia A. Aaron, Dhananjay Wagh, Nicole Pham, Mirko Scheibinger, Ruiqi Zhou, Akira Ishiyama, Lindsay S. Moore, Peter Santa Maria, Nikolas H. Blevins, Robert K. Jackler, Jennifer C. Alyono, John Kveton, Dhasakumar Navaratnam, Stefan Heller, Ivan A. Lopez, Nicolas Grillet, Taha A. Jan, Alan G. Cheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate in
Externí odkaz:
https://doaj.org/article/bbd2c632a6e24a05853cb5f0c56c9d00
Autor:
Pei Wang, Katharine K. Miller, Enqi He, Siddhant S. Dhawan, Christopher L. Cunningham, Nicolas Grillet
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/33f24251274c405eb2f7bca37515518a
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101431- (2022)
Summary: High-resolution immunofluorescence imaging of cochlear hair bundles faces many challenges due to the hair bundle’s small dimensions, fragile nature, and complex organization. Here, we describe an optimized protocol for hair-bundle protein
Externí odkaz:
https://doaj.org/article/9446629ed7e2465f8d0a41cd6786df5b
Autor:
Qu Deng, Ramakrishnan Natesan, Florencia Cidre-Aranaz, Shehbeel Arif, Ying Liu, Reyaz ur Rasool, Pei Wang, Erick Mitchell-Velasquez, Chandan Kanta Das, Endrit Vinca, Zvi Cramer, Patrick J. Grohar, Margaret Chou, Chandan Kumar-Sinha, Kristy Weber, T.S. Karin Eisinger-Mathason, Nicolas Grillet, Thomas Grünewald, Irfan A. Asangani
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110971- (2022)
Summary: Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription prog
Externí odkaz:
https://doaj.org/article/28e40682ce2f41f69b105d59455a86a7
Autor:
Nicolas Grillet
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101213- (2022)
Summary: Scanning electron microscopy (SEM) allows cell surface imaging at a sub-nanometric resolution. However, the sample requires a specific preparation to sustain the high vacuum of the SEM and be electrically conductive. The sample preparation c
Externí odkaz:
https://doaj.org/article/74fa4f05d2f9401ca39ebeb2eb45e039
Autor:
Katharine K. Miller, Patrick Atkinson, Kyssia Ruth Mendoza, Dáibhid Ó Maoiléidigh, Nicolas Grillet
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The hair bundle is the mechanosensory organelle of hair cells that detects mechanical stimuli caused by sounds, head motions, and fluid flows. Each hair bundle is an assembly of cellular-protrusions called stereocilia, which differ in height to form
Externí odkaz:
https://doaj.org/article/6b9c0467c9d248ffa8fe39a7109d45be
Autor:
Ksenia A. Aaron, Davood K. Hosseini, Yona Vaisbuch, Mirko Scheibinger, Nicolas Grillet, Stefan Heller, Tian Wang, Alan G. Cheng
Publikováno v:
Otol Neurotol
OBJECTIVE: To identify optimal conditions for recovering viable inner ear tissues from deceased organ donors. SETTING: Tertiary recovery hospitals and Donor Network West Organ Recovery Center. INTERVENTIONS: Recovering bilateral inner ear tissues and
Autor:
Tian Wang, Angela H. Ling, Sara E. Billings, Davood K. Hosseini, Yona Vaisbuch, Grace S. Kim, Patrick J. Atkinson, Zahra N. Sayyid, Ksenia A. Aaron, Dhananjay Wagh, Nicole Pham, Mirko Scheibinger, Akira Ishiyama, Peter Santa Maria, Nikolas H. Blevins, Robert K. Jackler, Stefan Heller, Ivan A. Lopez, Nicolas Grillet, Taha A. Jan, Alan G. Cheng
Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate remains unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d51fc5ccbf2422a031a62c457d223be
https://doi.org/10.1101/2022.10.29.514378
https://doi.org/10.1101/2022.10.29.514378