Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

Autor: Muhammad Qamar Saeed, Noelle Dufour, Cynthia Bartholmae, Urzula Sieranska, Malaika Knopf, Eloïse Thierry, Sylvain Thierry, Olivier Delelis, Nicolas Grandchamp, Héloïse Pilet, Philippe Ravassard, Julie Massonneau, Françoise Pflumio, Christof von Kalle, François Lachapelle, Alexis-Pierre Bemelmans, Manfred Schmidt, Ché Serguera

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)

HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin. Consequently, their preferential integration in transcribed genes

Externí odkaz: https://doaj.org/article/8f43f6c5cf2d499f95a79b299d2538d0

Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy.

Autor: Corinne Kostic, Simon Geoffrey Lillico, Sylvain Vincent Crippa, Nicolas Grandchamp, Héloïse Pilet, Stéphanie Philippe, Zen Lu, Tim James King, Jacques Mallet, Chamsy Sarkis, Yvan Arsenijevic, Christopher Bruce Alexander Whitelaw

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71363 (2013)

Large animal models are an important resource for the understanding of human disease and for evaluating the applicability of new therapies to human patients. For many diseases, such as cone dystrophy, research effort is hampered by the lack of such m

Externí odkaz: https://doaj.org/article/7784ac9227994fef97df496cab29b329

Pharmacodynamic Evaluation: Gene Therapy

Autor: Nicolas Grandchamp

Publikováno v: Drug Discovery and Evaluation: Methods in Clinical Pharmacology ISBN: 9783319566375

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cfb890c83b58e11c189180223c04c3
https://doi.org/10.1007/978-3-319-68864-0_51

Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy

Autor: Héloïse Pilet, Jacques Mallet, Stéphanie Philippe, Nicolas Grandchamp, Yvan Arsenijevic, Zen H. Lu, Simon G. Lillico, Sylvain V. Crippa, Corinne Kostic, Christopher Bruce Alexander Whitelaw, Tim King, Chamsy Sarkis

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71363 (2013)
Kostic, C, Lillico, S G, Crippa, S V, Grandchamp, N, Pilet, H, Philippe, S, Lu, Z, King, T J, Mallet, J, Sarkis, C, Arsenijevic, Y & Whitelaw, C B A 2013, ' Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy ', PLoS ONE, vol. 8, no. 8, pp. e71363 . https://doi.org/10.1371/journal.pone.0071363
PLoS ONE
Plos One, vol. 8, no. 8, pp. e71363
Scopus-Elsevier

Large animal models are an important resource for the understanding of human disease and for evaluating the applicability of new therapies to human patients. For many diseases, such as cone dystrophy, research effort is hampered by the lack of such m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9b633c7cbc38eaff8ee0ccbaa1aae4
http://europepmc.org/articles/PMC3747164?pdf=render

Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors

Autor: Suzanna Ursulet, Stéphanie Philippe, Jacques Mallet, Chamsy Sarkis, Dorothée Henriot, Nicolas Grandchamp, Che Serguera, Lahouari Amar

Publikováno v: Genetic Vaccines and Therapy
Genetic Vaccines and Therapy, 2011, 9 (1), pp.1. ⟨10.1186/1479-0556-9-1⟩
Genetic Vaccines and Therapy, BioMed Central, 2011, 9 (1), pp.1. ⟨10.1186/1479-0556-9-1⟩

Background The efficacy and biosafety of lentiviral gene transfer is influenced by the design of the vector. To this end, properties of lentiviral vectors can be modified by using cis-acting elements such as the modification of the U3 region of the L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff7b5fecf0d58565637902384018bff
https://www.hal.inserm.fr/inserm-00663700/file/1479-0556-9-1.pdf