Crosstalk between Acidosis and Iron Metabolism: Data from In Vivo Studies

Autor: Raêd Daher, Nicolas Ducrot, Thibaud Lefebvre, Sofia Zineeddine, Jérome Ausseil, Hervé Puy, Zoubida Karim

Publikováno v: Metabolites, Vol 12, Iss 2, p 89 (2022)

Iron absorption requires an acidic environment that is generated by the activity of the proton pump gastric H(+)/K(+)ATPase (ATP4), expressed in gastric parietal cells. However, hepcidin, the iron regulatory peptide that inhibits iron absorption, une

Externí odkaz: https://doaj.org/article/0c1d6a3504354770a50029d71f3d9505

Luspatercept (RAP-536) modulates oxidative stress without affecting mutation burden in myelodysplastic syndromes

Autor: Meunier Mathieu, Chloé Friedrich, Nicolas Ducrot, Johanna Zannoni, Tondeur Sylvie, Nelly Jerraya, Sophie Rousseaux, Florent Chuffart, Olivier Kosmider, Zoubida Karim, Sophie Park

Publikováno v: Annals of Hematology
Annals of Hematology, 2022, 101 (12), pp.2633-2643. ⟨10.1007/s00277-022-04993-7⟩

International audience; In low-risk myelodysplastic syndrome (LR-MDS), erythropoietin (EPO) is widely used for the treatment of chronic anemia. However, initial response to EPO has time-limited effects. Luspatercept reduces red blood cell transfusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717bcea9fd75544d2123b09dfa93c9de
https://doi.org/10.1007/s00277-022-04993-7

Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model

Autor: Sarah, Millot, Constance, Delaby, Boualem, Moulouel, Thibaud, Lefebvre, Nathalie, Pilard, Nicolas, Ducrot, Cécile, Ged, Philippe, Lettéron, Lucia, de Franceschi, Jean Charles, Deybach, Carole, Beaumont, Laurent, Gouya, Hubert, De Verneuil, Saïd, Lyoumi, Hervé, Puy, Zoubida, Karim

Publikováno v: Haematologica. 102(2)

Hemolysis occurring in hematologic diseases is often associated with an iron loading anemia. This iron overload is the result of a massive outflow of hemoglobin into the bloodstream, but the mechanism of hemoglobin handling has not been fully elucida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4290cb0552dbb84679b3368a9027bca
https://pubmed.ncbi.nlm.nih.gov/28143953

Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli

Autor: Dounia Houamel, Philippe Lettéron, Hervé Puy, Alain Vandewalle, Sarah Millot, Marie-Agnès Sari, Erick Denamur, Sophie Vaulont, Said Lyoumi, Carole Beaumont, Thibaud Lefebvre, Zoubida Karim, Boualem Moulouel, Nicolas Ducrot, Raed Daher, Odile Bouvet, Jerome Tourret, Laurent Gouya

The iron-regulatory peptide hepcidin exhibits antimicrobial activity. Having previously shown hepcidin expression in the kidney, we addressed its role in urinary tract infection (UTI), which remains largely unknown. Experimental UTI was induced in wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2896c96d2a20a9ecec20eb24cce3d9db
https://europepmc.org/articles/PMC4769187/

FAS-L, IL-10, and double-negative CD4-CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function

Autor: Olivier Hermine, Capucine Picard, Frédéric Rieux-Laucat, Olivier Lambotte, José Barbot, Eric Solary, Brigitte Bader-Meunier, Jean-Laurent Casanova, Marie-Claude Stolzenberg, Benoit Florkin, Claire Fieschi, Françoise Le Deist, Nicolas Ducrot, Bénédicte Neven, Aude Magerus-Chatinet, Alina Ferster, Marianne Debré, Catherine Schaffner, Alain Fischer, Peter D. Arkwright, Stéphane Blanche, Maria S. Loffredo, Claire Galambrun, Caroline Thomas

Publikováno v: Blood
Blood, American Society of Hematology, 2009, 113, pp.3027-3030
Magerus-Chatinet, A, Stolzenberg, M C, Loffredo, M S, Neven, B, Schaffner, C, Ducrot, N, Arkwright, P D, Bader-Meunier, B, Barbot, J, Blanche, S, Casanova, J L, Debré, M, Ferster, A, Fieschi, C, Florkin, B, Galambrun, C, Hermine, O, Lambotte, O, Solary, E, Thomas, C, Deist, F L, Picard, C, Fischer, A & Rieux-Laucat, F 2009, ' FAS-L, IL-10, and double-negative CD4-CD8-TCR α/β + T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function ', Blood, vol. 113, no. 13, pp. 3027-3030 . https://doi.org/10.1182/blood-2008-09-179630

Autoimmune lymphoproliferative syndrome (ALPS) is characterized by splenomegaly, lymphadenopathy, hypergammaglobulinemia, accumulation of double-negative TCRαβ+ CD4−CD8− T cells (DNT cells), and autoimmunity. Previously, DNT cell detection and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63dc8f81ee07a007a189de106a22d5d
https://hal.archives-ouvertes.fr/hal-00397943