Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nicolas Diguet"'
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
Autor:
Chiara V. Ragni, Nicolas Diguet, Jean-François Le Garrec, Marta Novotova, Tatiana P. Resende, Sorin Pop, Nicolas Charon, Laurent Guillemot, Lisa Kitasato, Caroline Badouel, Alexandre Dufour, Jean-Christophe Olivo-Marin, Alain Trouvé, Helen McNeill, Sigolène M Meilhac
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Growth of the mammalian heart is controlled by Hippo signalling but how this is regulated is unclear. Here, the authors show that Fat4 (an atypical cadherin) acts upstream of Hippo signalling and Fat4 mutant mice have thicker myocardium, which is med
Externí odkaz:
https://doaj.org/article/e8f4fd524d4c427fa1e8c9b37e7353f2
Autor:
Susanne Roesch, Emilie Royere, Willy Gosgnach, Ariane Bonnin, Benoit Tyl, Elodie Bossard, Patricia Sansilvestri-Morel, Pascal Berson, Muriel Bouly, Michel Komajda, Laura Xuereb, Nicolas Diguet, Pascal Rigouin, Peter Bernhardt, Marie-Pierre Bourguignon
Publikováno v:
Translational Research. 238:36-48
Little is known about the mechanisms of aging on vascular beds and its relationship with tetra and di-hydrobiopterin (BH4 and BH2) levels. This observational clinical study analyzed the impact of aging on plasma and platelet biopterins, cutaneous blo
Autor:
Javier Díez, Najah Harouki-Crochemore, Patricia Sansilvestri-Morel, Hélène Bertheux, Emilie Desfosses, Guy Vermeil de Conchard, Arantxa González, Florence Bertin, Isabelle Tupinon-Mathieu, Nicolas Diguet, Philippe Delerive, Mathilde Lecomte
Publikováno v:
Journal of cardiovascular pharmacology. 78(5)
Maturation of fibrillar collagen is known to play a crucial role in the pathophysiology of myocardial fibrosis. Procollagen C-proteinase enhancer 1 (PCPE1) has a key role in procollagen maturation and collagen fibril formation. The phenotype of both
Autor:
Joffrey Zoll, Jean-François Decaux, Mathias Mericskay, Marie Breton, Anne Garnier, Boris Manoury, Mélanie Gressette, Cynthia Tannous, Jérôme Piquereau, Charles Brenner, Nicolas Diguet, István Baczkó, Samuel A.J. Trammell, Jocelyne Blanc, Zhenlin Li, Anne Gouge, Nathalie Mougenot, Gareth G. Lavery, Robin Deloux
Publikováno v:
Circulation
Circulation, 2018, 137 (21), pp.2256-2273. ⟨10.1161/CIRCULATIONAHA.116.026099⟩
Circulation, American Heart Association, 2018, 137 (21), pp.2256-2273. ⟨10.1161/CIRCULATIONAHA.116.026099⟩
Circulation, 2018, 137 (21), pp.2256-2273. ⟨10.1161/CIRCULATIONAHA.116.026099⟩
Circulation, American Heart Association, 2018, 137 (21), pp.2256-2273. ⟨10.1161/CIRCULATIONAHA.116.026099⟩
Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, nicotina
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
Autor:
Chiara V. Ragni, Jean-François Le Garrec, Jean-Christophe Olivo-Marin, Laurent Guillemot, Tatiana P. Resende, Alain Trouvé, Sigolène M. Meilhac, Helen McNeill, Lisa Kitasato, Nicolas Diguet, Marta Novotova, Nicolas Charon, Alexandre Dufour, Sorin Pop, Caroline Badouel
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, pp.14582. ⟨10.1038/ncomms14582⟩
Nature Communications, 2017, 8, pp.14582. ⟨10.1038/ncomms14582⟩
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Nature Publishing Group, 2017, 8, pp.14582. ⟨10.1038/ncomms14582⟩
Nature Communications, 2017, 8, pp.14582. ⟨10.1038/ncomms14582⟩
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Although in flies the atypical cadherin Fat is an upstream regulator of Hippo signalling, the closest mammalian homologue, Fat4, has been shown to regulate tissue polarity rather than growth. Here we show in the mouse heart that Fat4 modulates Hippo
Publikováno v:
Biologie Aujourd'hui. 205:139-146
Intracellular protein filaments intermediate in size between actin filaments and microtubules are composed of a variety of tissue specific proteins. The sequence conservation of the coiled-coil alpha-helical structure responsible for polymerization i
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 10:229
Introduction NAD+ is a key co-enzyme in energy metabolism and a signaling substrate used by the sirtuins and poly (ADPribose) polymerases (PARPs), regulating energy metabolism and oxidative stress response. Myocardial NAD+ levels are reduced in vario
The primary cilium is a small sensory organelle that is required for different aspects of embryonic development, including the formation of the heart. The structure and composition of cilia have been extensively studied, so that several markers of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927ed9cb322184b2e2b8d79cf0aeaac1
https://doi.org/10.1016/bs.mcb.2015.01.008
https://doi.org/10.1016/bs.mcb.2015.01.008
Autor:
Nicolas, Diguet, Sigolène M, Meilhac
Publikováno v:
Medecine sciences : M/S. 30(11)
After the seminal discovery in 2000 that primary cilia are functional organelles which are essential for embryonic development, several mouse models of ciliopathies have been generated. The heart is frequently affected, with a large spectrum of malfo
Autor:
Mathias Mericskay, Daniele Catalucci, Jocelyne Blanc, Youssef Mallat, Brigitte Escoubet, Florence Lefebvre, Grégoire Vandecasteele, Leon J. De Windt, Nicolas Diguet, Eva Tritsch, Zhenlin Li
Publikováno v:
Cardiovascular Research, 98(3), 372-380. Oxford University Press
Cardiovascular Research
Cardiovascular Research, 2013, 98 (3), pp.372-380. ⟨10.1093/cvr/cvt042⟩
Cardiovascular Research, Oxford University Press (OUP), 2013, 98 (3), pp.372-380. ⟨10.1093/cvr/cvt042⟩
Cardiovascular Research
Cardiovascular Research, 2013, 98 (3), pp.372-380. ⟨10.1093/cvr/cvt042⟩
Cardiovascular Research, Oxford University Press (OUP), 2013, 98 (3), pp.372-380. ⟨10.1093/cvr/cvt042⟩
Aims The expression of the sodium/calcium exchanger NCX1 increases during cardiac hypertrophy and heart failure playing an important role in Ca2+ extrusion. This increase is presumed to result from stress signaling induced changes in the interplay be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a78a3ddc5bf37b2bb14694c7442515
https://cris.maastrichtuniversity.nl/en/publications/2cf96753-e34f-4cc5-b3cb-225ccd219bb6
https://cris.maastrichtuniversity.nl/en/publications/2cf96753-e34f-4cc5-b3cb-225ccd219bb6