MALDI-MSI Towards Multimodal Imaging: Challenges and Perspectives

Autor: Michael Tuck, Florent Grélard, Landry Blanc, Nicolas Desbenoit

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

Multimodal imaging is a powerful strategy for combining information from multiple images. It involves several fields in the acquisition, processing and interpretation of images. As multimodal imaging is a vast subject area with various combinations o

Externí odkaz: https://doaj.org/article/c36e442c93894d1d86ac16c01ccf0e83

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits.

Autor: Françoise Brignole-Baudouin, Nicolas Desbenoit, Gregory Hamm, Hong Liang, Jean-Pierre Both, Alain Brunelle, Isabelle Fournier, Vincent Guerineau, Raphael Legouffe, Jonathan Stauber, David Touboul, Maxence Wisztorski, Michel Salzet, Olivier Laprevote, Christophe Baudouin

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e50180 (2012)

We investigated in a rabbit model, the eye distribution of topically instilled benzalkonium_(BAK) chloride a commonly used preservative in eye drops using mass spectrometry imaging. Three groups of three New Zealand rabbits each were used: a control

Externí odkaz: https://doaj.org/article/0e48dab77fee420da2f8b75cb7178b4f

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling

Autor: Rodrigue Rossignol, Pauline Esteves, Matthieu Thumerel, Thomas Trian, Florian Bellvert, Landry Blanc, A. Celle, Pierre-Olivier Girodet, Elise Maurat, Isabelle Dupin, Olga Ousova, Nicolas Desbenoit, Hugues Begueret, Nivea Dias Amoedo, Lara Gales, Guillaume Cardouat, Patrick Berger, Roger Marthan, Jean-William Dupuy

Publikováno v: European Respiratory Journal
European Respiratory Journal, European Respiratory Society, 2021, pp.2004252. ⟨10.1183/13993003.04252-2020⟩
European Respiratory Journal, 2021, 58 (5), pp.2004252. ⟨10.1183/13993003.04252-2020⟩

BackgroundBronchial smooth muscle (BSM) remodelling in asthma is related to an increased mitochondrial biogenesis and enhanced BSM cell proliferation in asthma. Since mitochondria produce the highest levels of cellular energy and fatty acid β-oxidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bec5f888f26c157c439ed4289a22868
https://doi.org/10.1183/13993003.04252-2020

TOF-SIMS/MALDI-TOF combination for the molecular weight depth profiling of polymeric bilayer

Autor: Grégory Mertz, Thierry Fouquet, Nicolas Desbenoit, Gilles Frache, David S. Ruch

Publikováno v: Materials Letters. 128:23-26

A polymeric bilayer composed of two poly(styrene) layers differing by their molecular weights (MW) was elaborated to mimic a MW gradient and analyzed by a combination of TOF-SIMS, MALDI-MS and Nanoscratch (NS). A direct TOF-SIMS profiling conducted u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9832c0ed5ccf6463f31471101088065e
https://doi.org/10.1016/j.matlet.2014.04.119

imzML — A common data format for the flexible exchange and processing of mass spectrometry imaging data

Autor: Bernhard Spengler, Markus Stoeckli, Andreas Römpp, Thorsten Schramm, Ron M. A. Heeren, Marie-France Robbe, Ivo Klinkert, Olivier Laprévote, Nicolas Desbenoit, Jean-Pierre Both, Alain Brunelle, Alfons Hester

Publikováno v: Journal of Proteomics
Journal of Proteomics, 2012, 75 (16), pp.5106-10. ⟨10.1016/j.jprot.2012.07.026⟩
Journal of Proteomics, Elsevier, 2012, 75 (16), pp.5106-10. ⟨10.1016/j.jprot.2012.07.026⟩

International audience; The application of mass spectrometry imaging (MS imaging) is rapidly growing with a constantly increasing number of different instrumental systems and software tools. The data format imzML was developed to allow the flexible a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2af42ae6641f29b9dc851833230559
https://doi.org/10.1016/j.jprot.2012.07.026