Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nicolas Damond"'
Autor:
Johanna Wagner, Markus Masek, Andrea Jacobs, Charlotte Soneson, Sujana Sivapatham, Nicolas Damond, Natalie de Souza, Mark D. Robinson, Bernd Bodenmiller
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-16 (2022)
Measurement(s) RNA-seq gene expression profiling assay • cell surface proteins • protein expression at the single-cell level • Epithelial-to-Mesenchymal Transition • breast cancer cell • mammary gland epithelial cell Technology Type(s) mRNA
Externí odkaz:
https://doaj.org/article/81a2b53781e4443a83618d3a2b4f6b3d
Autor:
Sylvain Loubéry, Alicia Daeden, Carole Seum, Laurent Holtzer, Ana Moraleda, Nicolas Damond, Emmanuel Derivery, Thomas Schmidt, Marcos Gonzalez-Gaitan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Asymmetric segregation of cell fate determinants during cell division governs daughter cell fate. Here the authors show that Sara endosomes, known to regulate Notch signalling, are targeted to the mitotic spindle and once phosphorylated are asymmetri
Externí odkaz:
https://doaj.org/article/4e05d4052c0e463fa6494f9179a2fc71
Autor:
Nicolas Damond, Fabrizio Thorel, Julie S Moyers, Maureen J Charron, Patricia M Vuguin, Alvin C Powers, Pedro L Herrera
Publikováno v:
eLife, Vol 5 (2016)
Glucagon secretion dysregulation in diabetes fosters hyperglycemia. Recent studies report that mice lacking glucagon receptor (Gcgr-/-) do not develop diabetes following streptozotocin (STZ)-mediated ablation of insulin-producing β-cells. Here, we s
Externí odkaz:
https://doaj.org/article/b5336ac240d94ff58a8df5bdcb8a68d4
Autor:
Markus Masek, Mark D. Robinson, Andrea Jacobs, Natalie de Souza, Charlotte Soneson, Nicolas Damond, Bernd Bodenmiller, Sujana Sivapatham, Johanna Wagner
Epithelial-mesenchymal transition (EMT) equips breast cancer cells for metastasis and treatment resistance. Inhibition and elimination of EMT-undergoing cells are therefore promising therapy approaches. However, detecting EMT-undergoing cells is chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d4a4a5010245f141a833c277de28bf
https://doi.org/10.1101/2021.03.26.436976
https://doi.org/10.1101/2021.03.26.436976
SUMMARYHighly multiplexed imaging technologies enable spatial profiling of dozens of biomarkersin situ. Standard data processing pipelines quantify cell-specific features and generate object segmentation masks as well as multi-channel images. Therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5682bb7d035474df16ff048d4bcce53d
https://doi.org/10.1101/2020.09.08.287516
https://doi.org/10.1101/2020.09.08.287516
Publikováno v:
Bioinformatics
Summary Highly multiplexed imaging technologies enable spatial profiling of dozens of biomarkers in situ. Here, we describe cytomapper, a computational tool written in R, that enables visualization of pixel- and cell-level information obtained by mul
Publikováno v:
The International Journal of Biochemistry & Cell Biology, Vol. 88 (2017) pp. 226-235
In addition to β-cells, pancreatic islets contain α- and δ-cells, which respectively produce glucagon and somatostatin. The reprogramming of these two endocrine cell types into insulin producers, as observed after a massive β-cell ablation in mic
Autor:
Fabrizio Thorel, Bernd Bodenmiller, Mark A. Atkinson, Harry S. Nick, Clive Wasserfall, Vito R T Zanotelli, Denis Schapiro, Nicolas Damond, Stefanie Engler, Irina Kusmartseva, Pedro Luis Herrera
Publikováno v:
Cell Metabolism, Vol. 29, No 3 (2019) pp. 755-768.e5
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β cells. A comprehensive picture of the changes during T1D development is lacking due to limited sample availability, inability to sample longitudinally, and the pauc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905b1fddf449897c954f1654148ed992
https://europepmc.org/articles/PMC6821395/
https://europepmc.org/articles/PMC6821395/
Autor:
Marcos González-Gaitán, Emmanuel Derivery, Sylvain Loubéry, Carole Seum, Nicolas Damond, Ana Moraleda, Thomas Schmidt, Laurent Holtzer, Alicia Daeden
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol. 8, No 1 (2017)
Nature Communications
Nature Communications, Vol. 8, No 1 (2017)
Nature Communications
During asymmetric division, fate assignation in daughter cells is mediated by the partition of determinants from the mother. In the fly sensory organ precursor cell, Notch signalling partitions into the pIIa daughter. Notch and its ligand Delta are e
Autor:
Jesper Gromada, Hai Yan, Pedro Luis Herrera, Timothy J. Kieffer, Nicolas Damond, Kyle W. Sloop, William L. Holland, Young H Lee, Jens J. Holst, Roger H Unger
Publikováno v:
Holst, J J, Holland, W, Gromada, J, Lee, Y, Unger, R H, Yan, H, Sloop, K W, Kieffer, T J, Damond, N & Herrera, P L 2017, ' Insulin and Glucagon : Partners for Life ', Endocrinology, vol. 158, no. 4, pp. 696-701 . https://doi.org/10.1210/en.2016-1748
Endocrinology, Vol. 158, No 4 (2017) pp. 696-701
Endocrinology
Endocrinology, Vol. 158, No 4 (2017) pp. 696-701
Endocrinology
Is glucagon essential for the hyperglycemia in insulin deficiency, as suggested by experimental glucagon antagonism? No, sufficient levels of basal insulin must be present to prevent hyperglycemia.
In August 2016, several leaders in glucagon bio
In August 2016, several leaders in glucagon bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0044f4832cbead856329042b36955557
https://curis.ku.dk/ws/files/188521763/en.2016_1748.pdf
https://curis.ku.dk/ws/files/188521763/en.2016_1748.pdf