Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Nicolas Christoforou"'
Autor:
Kevin E. McElhanon, Tyler C. Huff, Dinesh Hirenallur-Shanthappa, Russell A. Miller, Nicolas Christoforou
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and the incidence of new-onset AF has been increasing over the past two decades. Several factors contribute to the risk of developing AF including age, preexisting cardiovasc
Externí odkaz:
https://doaj.org/article/3ef4bdcfcc87462d98bc7d6ea3e62edc
Autor:
Christopher M. Brennan, Abby S. Hill, Michael St. Andre, Xianfeng Li, Vijaya Madeti, Susanne Breitkopf, Seth Garren, Liang Xue, Tamara Gilbert, Angela Hadjipanayis, Mara Monetti, Charles P. Emerson, Robert Moccia, Jane Owens, Nicolas Christoforou
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/1bbf0c3ccd564919803d206fc16f77d4
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their
Externí odkaz:
https://doaj.org/article/a3214fa4553b41159e0f55af7a3cb596
Autor:
Santosh Hariharan, Oana Lorintiu, Chia-Chin Lee, Eve Duchemin-Pelletier, Xianfeng Li, Aileen Healy, Regis Doyonnas, Luc Selig, Pauline Poydenot, Erwann Ventre, Andrea Weston, Jane Owens, Nicolas Christoforou
Duchenne muscular dystrophy (DMD) is a progressive and fatal muscle degenerating disease caused by dystrophin deficiency. Effective methods for drug discovery for the treatment of DMD requires systems to be physiologically relevant, scalable, and eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcb8fb30b4a5f99ff74734290a8ac0aa
https://doi.org/10.1101/2023.05.24.542079
https://doi.org/10.1101/2023.05.24.542079
Autor:
Khaled M. A. Abdel-Raouf, Rachid Rezgui, Cesare Stefanini, Jeremy C. M. Teo, Nicolas Christoforou
Publikováno v:
Biology, Vol 10, Iss 6, p 539 (2021)
The development of robust skeletal muscle models has been challenging due to the partial recapitulation of human physiology and architecture. Reliable and innovative 3D skeletal muscle models recently described offer an alternative that more accurate
Externí odkaz:
https://doaj.org/article/cff72245746b42a28e7b2233bb7fe70b
Autor:
Wei Zhou, David Tester, Nicolas Christoforou, Changsung J. Kim, Mariana Bego, Lisa Keyes, Jane Owens, Jason Pinkstaff, Gabriel Brooks, Michael J. Ackerman
Publikováno v:
Heart Rhythm. 20:S41-S42
Autor:
Martina Gluscevic, Changsung J. Kim, David Tester, Nicolas Christoforou, Mariana Bego, Lisa Keyes, Jane Owens, Jason Pinkstaff, Ramin Garmany, Gabriel Brooks, Michael J. Ackerman
Publikováno v:
Heart Rhythm. 20:S42-S43
Autor:
Syandan Chakraborty, HaYeun Ji, Ami M. Kabadi, Charles A. Gersbach, Nicolas Christoforou, Kam W. Leong
Publikováno v:
Stem Cell Reports, Vol 3, Iss 6, Pp 940-947 (2014)
Gene activation by the CRISPR/Cas9 system has the potential to enable new approaches to science and medicine, but the technology must be enhanced to robustly control cell behavior. We show that the fusion of two transactivation domains to Cas9 dramat
Externí odkaz:
https://doaj.org/article/930026d722764cd4846de3bb46a8f911
Autor:
Sahej Bains, Lucilla Giammarino, Saranda Nimani, Nicolo Alerni, David Tester, Nicolas Christoforou, Julien Louradour, Thomas S. Hof, Olgica Beslac, Miriam Barbieri, Lluis Matas, Andras Horvath, Ruben Lopez, Stefanie Perez-Feliz, Changsung J. Kim, Wei Zhou, Dan Ye, Jacqulyn Jurgensen, Michael A. Barry, Mariana Bego, Lisa Keyes, Jane Owens, Jason Pinkstaff, Gideon Koren, Manfred Zehender, Michael Brunner, Daniela Casoni, Fabien Praz, Andreas Haeberlin, Gabriel Brooks, Katja E. Odening, Michael J. Ackerman
Publikováno v:
Heart Rhythm. 20:S278
Autor:
Cristina Morera, Jihee Kim, Amaia Paredes-Redondo, Muriel Nobles, Denis Rybin, Robert Moccia, Anna Kowala, Jinhong Meng, Seth Garren, Pentao Liu, Jennifer E Morgan, Francesco Muntoni, Nicolas Christoforou, Jane Owens, Andrew Tinker, Yung-Yao Lin
Mutations in thedystrophingene cause the most common and currently incurable Duchenne muscular dystrophy (DMD) characterized by progressive muscle wasting. Although abnormal Ca2+handling is a pathological feature of DMD, mechanisms underlying defecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44521229c905ddc8e2d9985a0443638a
https://doi.org/10.1101/2022.02.17.480850
https://doi.org/10.1101/2022.02.17.480850