Radical Allylation with α-Branched Allyl Sulfones

Autor: Nicolas Charrier, Samir Z. Zard

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, 47 (49), pp.9443-9446. ⟨10.1002/anie.200804298⟩

International audience; (Chemical Equation Presented) Branching out with sulfones: The use of allyl isopropyl sulfones solves the problem of premature isomerization and allows the radical addition of xanthates to a-branched allyl sulfones (see scheme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd8192d46721aa6d1d7c52f858f1ba9
https://doi.org/10.1002/anie.200804298

Synthesis of 3,5,7-Substituted Indoles via Heck Cyclisation

Autor: G. Maile, P. Theobald, Nicolas Charrier, Alan Naylor, R. Dunsdon, Daryl S. Walter, A. O'Brien, D. Vesey, Emmanuel Hubert Demont, Sally Redshaw

Publikováno v: Synlett. :3071-3074

Traditional strategies in indole chemistry do not allow high yielding access to some substitution patterns such as 3,5,7-trisubstituted indoles. We report in this article the efficient synthesis of this type of indole. The Heck cyclisation strategy w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95062aaf316965556e06717750f22f37
https://doi.org/10.1055/s-2005-921917

Desulfonylative radical ring closure onto aromatics. A modular route to benzazepin-2-ones and 5-arylpiperidin-2-ones

Autor: Nicolas Charrier, Samir Z. Zard, Zhibo Liu

Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2012, 14 (8), pp.2018-2021. ⟨10.1021/ol3005276⟩

International audience; Adducts from the intermolecular radical addition of N-xanthylacetyl-N-methanesulfanilides to Boc-protected allylamine undergo ring closure with loss of a methanesulfonyl radical to give benzazepin-2-ones. Upon deprotection and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91df8bf763d7f149279d2e19fd3ee09b
https://hal-polytechnique.archives-ouvertes.fr/hal-00949983

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics

Autor: Ishrut Hussain, G. Maile, A. O'Brien, Gareth Wayne, Julie Hawkins, Daryl S. Walter, Sharon Sweitzer, Virginie Soleil, B. Clarke, P. Theobald, Colin Dingwall, Emmanuel Hubert Demont, Alan Naylor, Paul Rowland, Rosalie Matico, Kathrine J. Smith, Leanne Cutler, J. Mosley, C. Howes, Sally Redshaw, R. Dunsdon, Julia A. Hubbard, Nicolas Charrier, D. Vesey

Publikováno v: Bioorganicmedicinal chemistry letters. 19(13)

Our first generation of hydroxyethylamine BACE-1 inhibitors proved unlikely to provide molecules that would lower amyloid in an animal model at low oral doses. This observation led us to the discovery of a second generation of inhibitors having nanom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836066c48bc0736fb08b7d4a29c3cf6e
https://pubmed.ncbi.nlm.nih.gov/19406640

ChemInform Abstract: Allylic Alcohols as Radical Allylating Agents. An Overall Olefination of Aldehydes and Ketones

Autor: Samir Z. Zard, Nicolas Charrier, Beatrice Quiclet‐Sire

Publikováno v: ChemInform. 39

2-Fluoropyridyl derivatives of allylic alcohols react with xanthates in the presence of lauroyl peroxide to give alkenes, often with high stereoselectivity. If the allylic alcohols are themselves derived from aldehydes or ketones, the overall process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbc1278969dea8673f427462324bc2c8
https://doi.org/10.1002/chin.200848042