Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicolas Camper"'
Autor:
Nick Evans, Ruslan Grygorash, Paul Williams, Andrew Kyle, Terrence Kantner, Ravindra Pathak, XiaoBo Sheng, Fabio Simoes, Hiteshri Makwana, Ricardo Resende, Elena de Juan, Alan Jenkins, David Morris, Aurelie Michelet, Frances Jewitt, Felicity Rudge, Nicolas Camper, Anaïs Manin, William McDowell, Martin Pabst, Antony Godwin, Mark Frigerio, Matthew Bird
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Antibody-drug conjugates (ADCs) have begun to fulfil their promise as targeted cancer therapeutics with ten clinical approvals to date. As the field matures, much attention has focused upon the key factors required to produce safe and efficacious ADC
Externí odkaz:
https://doaj.org/article/e322c470d7fb4d25b6de4ac481fa6602
Autor:
Katja E. Grier, Anders H. Hansen, Christina S. Haxvig, Xin Li, Oliver Krigslund, Niels Behrendt, Lars H. Engelholm, Fabio Rossi, Bebiana C. Sousa, Grant J. Harradence, Nicolas Camper, Katrine M. Qvortrup
Publikováno v:
Chemical Communications.
We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c8359bb7b2f4c21837af042db3bc89e
https://doi.org/10.1039/d3cc01596c
https://doi.org/10.1039/d3cc01596c
Autor:
Nick, Evans, Ruslan, Grygorash, Paul, Williams, Andrew, Kyle, Terrence, Kantner, Ravindra, Pathak, XiaoBo, Sheng, Fabio, Simoes, Hiteshri, Makwana, Ricardo, Resende, Elena, de Juan, Alan, Jenkins, David, Morris, Aurelie, Michelet, Frances, Jewitt, Felicity, Rudge, Nicolas, Camper, Anaïs, Manin, William, McDowell, Martin, Pabst, Antony, Godwin, Mark, Frigerio, Matthew, Bird
Publikováno v:
Frontiers in pharmacology. 13
Antibody-drug conjugates (ADCs) have begun to fulfil their promise as targeted cancer therapeutics with ten clinical approvals to date. As the field matures, much attention has focused upon the key factors required to produce safe and efficacious ADC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0c163869b09e4c7d83d87923217ec72
https://pubmed.ncbi.nlm.nih.gov/35784686
https://pubmed.ncbi.nlm.nih.gov/35784686
Autor:
Donna M. Small, Rebecca J. Ingram, Nicolas Camper, Joseph Elborn, Arlene Glasgow, Fionnuala Lundy, Derek J. Quinn, D. McLean, Megan Osbourn, Clifford C. Taggart, Sinéad Weldon, Paul McNally
Publikováno v:
Camper, N, Glasgow, A M A, Osbourn, M, Quinn, D J, Small, D M, McLean, D T, Lundy, F T, Elborn, J S, McNally, P, Ingram, R J, Weldon, S & Taggart, C C 2016, ' A Secretory Leukocyte Protease Inhibitor Variant with Improved Activity against Lung Infection ', Mucosal immunology, vol. 9, no. 3, pp. 669-676 . https://doi.org/10.1038/mi.2015.90
Secretory leukocyte protease inhibitor (SLPI) is an important respiratory tract host defense protein, which is proteolytically inactivated by excessive neutrophil elastase (NE) during chronic Pseudomonas infection in the cystic fibrosis (CF) lung. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49381f8320031a18898f3dd142c9010
https://doi.org/10.1038/mi.2015.90
https://doi.org/10.1038/mi.2015.90
Autor:
William McDowell, Julia Swierkosz, George Badescu, Andrew F. Kyle, Mark Frigerio, Amrita Abhilash, Ji-Won Choi, Estera Jamieson, Matthew P. Baker, XiaoBo Sheng, Matthew Bird, Penny Bryant, Ruslan Grygorash, Katarzyna Kozakowska, Korinna Henseleit, Rita Tommasi, Vimal Parekh, Kosma Jurlewicz, Karolina Peciak, Emmanuelle Laurine, Martin Pabst, Nicolas Camper, Antony Godwin, Anaïs Manin, Jeff Edwards, David Morris
Publikováno v:
Molecular Pharmaceutics. 12:1872-1879
The conjugation of monomethyl auristatin E (MMAE) to trastuzumab using a reduction bis-alkylation approach that is capable of rebridging reduced (native) antibody interchain disulfide bonds has been previously shown to produce a homogeneous and stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdafeb6a27047bdb000238cba2a009a
https://doi.org/10.1021/acs.molpharmaceut.5b00116
https://doi.org/10.1021/acs.molpharmaceut.5b00116
Autor:
Paul McNally, Cecilia O'Kane, Sinéad Weldon, Daniel F. McAuley, D. McLean, Nicolas Camper, J. Stuart Elborn, Donna M. Small, Fionnuala Lundy, Shauna Hegarty, Aaron Scott, Arlene Glasgow, Dhruv Parekh, Clifford C. Taggart, Umar Hamid
Publikováno v:
Glasgow, A M A, Small, D M, Scott, A, McLean, D T, Camper, N, Hamid, U, Hegarty, S, Parekh, D, O'Kane, C, Lundy, F T, McNally, P, Elborn, J S, McAuley, D F, Weldon, S & Taggart, C C 2015, ' A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung ', Thorax, vol. 70, no. 5, pp. 426-32 . https://doi.org/10.1136/thoraxjnl-2014-206488
Introduction: Secretory leucocyte protease inhibitor and elafin are members of the whey acidic protein (WAP), or WAP four disulfide-core (WFDC), family of proteins and have multiple contributions to innate defence including inhibition of neutrophil s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c260d0a0e2d9b337befb1907198476e
https://doi.org/10.1136/thoraxjnl-2014-206488
https://doi.org/10.1136/thoraxjnl-2014-206488
Autor:
Korinna Henseleit, Mark Frigerio, Antony Godwin, Jeff Edwards, XiaoBo Sheng, Matthew Bird, Martin Fisher, Kosma Jurlewicz, George Badescu, Amrita Abhilash, Penny Bryant, Estera Pawlisz, Ruslan Grygorash, Julia Swierkosz, Andrew F. Kyle, Monika Farys, Nicolas Camper, Vimal Parekh, Rita Tommasi
Publikováno v:
Bioconjugate Chemistry. 25:1124-1136
To improve both the homogeneity and the stability of ADCs, we have developed site-specific drug-conjugating reagents that covalently rebridge reduced disulfide bonds. The new reagents comprise a drug, a linker, and a bis-reactive conjugating moiety t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e41ca810ded9c08bfb53bf05fccd1
https://doi.org/10.1021/bc500148x
https://doi.org/10.1021/bc500148x
Autor:
Andrew F. Kyle, Matthew P. Baker, Carolyn Tucker, Derek Pollard, Terrence Kantner, Felicity Rudge, Antony Godwin, Gina Popa, Mark Frigerio, Hiteshri Makwana, George Badescu, Fabio Simoes, Anaïs Manin, Farzad Khayrzad, Katarzyna Kozakowska, Martin Pabst, Nicolas Camper, Dave Morris, Hemal Parekh, Paul Williams, Vimal Parekh, Xiao Bo Sheng, William McDowell, Elena De Juan, Alan Jenkins, Ricardo Resende, Aurelie Michelet, Matthew Bird
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 253
Antibody-drug conjugates (ADCs) are a promising class of anticancer agents which have undergone substantial development over the past decade and are now achieving clinical success. The development of novel site-specific conjugation technologies enabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0466a60d8733391dc06cb6003472ec
https://pubmed.ncbi.nlm.nih.gov/28257988
https://pubmed.ncbi.nlm.nih.gov/28257988
Autor:
Shane Olwill, Christopher J. Scott, Teresa Byrne, Marie E. Migaud, Roberta E. Burden, Breena Gray, Jenny Lowry, Nicolas Camper, James A. Johnston, Richard Buick
Publikováno v:
Journal of Immunological Methods. 372:30-41
Monoclonal antibodies and derivative formats such as Fab' fragments are used in a broad range of therapeutic, diagnostic and research applications. New systems and methodologies that can improve the production of these proteins are consequently of mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d576cc8fcbd0bd2124fbbbb4851f26
https://doi.org/10.1016/j.jim.2011.06.029
https://doi.org/10.1016/j.jim.2011.06.029
Autor:
David Pépin, André Nicolas, Delphine Desigaud, Jean-François Prost, Martine Pugnière, Olivier Dubreuil, Anaïs Manin, Jean-Marc Barret, William McDowell, Raghav Mohan, Nicolas Camper, Patricia K. Donahoe
Publikováno v:
Cancer Research. 78:1779-1779
The anti-Müllerian hormone (AMH) belongs to the TGF-β family and plays a key role during fetal sexual development. Its receptor, AMHRII, is selectively expressed in normal sexual organs in healthy adults. RT-PCR and In Situ Hybridization studies ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0846a788d959f42832fc53aa8f339a8a
https://doi.org/10.1158/1538-7445.am2018-1779
https://doi.org/10.1158/1538-7445.am2018-1779