RNA-Seq Transcriptome Analysis of Peripheral Blood From Cattle Infected With Mycobacterium bovis Across an Experimental Time Course

Autor: Kirsten E. McLoughlin, Carolina N. Correia, John A. Browne, David A. Magee, Nicolas C. Nalpas, Kevin Rue-Albrecht, Adam O. Whelan, Bernardo Villarreal-Ramos, H. Martin Vordermeier, Eamonn Gormley, Stephen V. Gordon, David E. MacHugh

Publikováno v: Frontiers in Veterinary Science, Vol 8 (2021)

Bovine tuberculosis, caused by infection with members of the Mycobacterium tuberculosis complex, particularly Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance

Externí odkaz: https://doaj.org/article/0a59da780d9844058e5ac7e541456e2c

Comparative functional genomics and the bovine macrophage response to strains of the Mycobacterium genus

Autor: Kévin eRue-Albrecht, David A. Magee, Kate E. Killick, Nicolas C. Nalpas, Stephen V. Gordon, David E. Machugh

Publikováno v: Frontiers in Immunology, Vol 5 (2014)

Mycobacterial infections are major causes of morbidity and mortality in cattle and are also potential zoonotic agents with implications for human health. Despite the implementation of comprehensive animal surveillance programs, many mycobacterial dis

Externí odkaz: https://doaj.org/article/7a1270ad73f140a69b238dba14a48ac0

High-resolution transcriptomics of bovine purified protein derivative-stimulated peripheral blood from cattle infected withMycobacterium bovisacross an experimental time course

Autor: Carolina N. Correia, Gillian P. McHugo, John A. Browne, Kirsten E. McLoughlin, Nicolas C. Nalpas, David A. Magee, Adam O. Whelan, Bernardo Villarreal-Ramos, H. Martin Vordermeier, Eamonn Gormley, Stephen V. Gordon, David E. MacHugh

ObjectivesImproved bovine tuberculosis (bTB) diagnostics with higher sensitivity and specificity are urgently required. A better understanding of the peripheral blood transcriptional response ofMycobacterium bovis-infected animals after bovine purifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f1159b074ab3730662d8094aac2025b
https://doi.org/10.1101/2022.04.19.488769

Individualized Proteogenomics Reveals the Mutational Landscape of Melanoma Patients in Response to Immunotherapy

Autor: Claus Garbe, Tobias Sinnberg, Marisa Schmitt, Heike Niessner, Boris Macek, Andrea Forschner, Nicolas C. Nalpas

Publikováno v: Cancers, Vol 13, Iss 5411, p 5411 (2021)
Cancers
Volume 13
Issue 21

Simple Summary Melanoma is the most aggressive form of skin cancer, with a rapidly increasing incidence rate. Due to ineffective treatment options in the late stage melanoma, patients have an overall poor prognosis. Over the last decades, the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0b80b0c2a8ea96149b0a65af1523d5
https://pubmed.ncbi.nlm.nih.gov/34771574

Proteome Dynamics during Antibiotic Persistence and Resuscitation

Autor: Payal Nashier, Till Englert, Fabio Lino Gratani, Viktor Beke, Shilpa Elizabeth George, Nicolas C. Nalpas, Boris Macek, Christiane Wolz, Maja Semanjski, Elsa Germain, Kenn Gerdes

Publikováno v: mSystems
mSystems, Vol 6, Iss 4 (2021)
American Societu for Microbiology
Semanjski, M, Gratani, F L, Englert, T, Nashier, P, Beke, V, Nalpas, N, Germain, E, George, S, Wolz, C, Gerdes, K & Macek, B 2021, ' Proteome Dynamics during Antibiotic Persistence and Resuscitation ', mSystems, vol. 6, no. 4, e00549-21 . https://doi.org/10.1128/mSystems.00549-21

During antibiotic persistence, bacterial cells become transiently tolerant to antibiotics by restraining their growth and metabolic activity. Detailed molecular characterization of antibiotic persistence is hindered by low count of persisting cells a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774384136ea39913d2f0175c984cd4d6
https://pubmed.ncbi.nlm.nih.gov/34427514