Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Nicolas Broin"'
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Akademický článek
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites
Autor: Claudie Bosc, Nicolas Broin, Marjorie Fanjul, Estelle Saland, Thomas Farge, Charly Courdy, Aurélie Batut, Rawand Masoud, Clément Larrue, Sarah Skuli, Nicolas Espagnolle, Jean-Christophe Pagès, Alice Carrier, Frédéric Bost, Justine Bertrand-Michel, Jérôme Tamburini, Christian Récher, Sarah Bertoli, Véronique Mansat-De Mas, Stéphane Manenti, Jean-Emmanuel Sarry, Carine Joffre
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
How autophagy supports tumor cell metabolism is not fully clear. Here, the authors show that autophagy regulates lipid availability to support mitochondrial oxidative metabolism through mitochondria-endoplasmic reticulum contact sites, necessary for
Externí odkaz: https://doaj.org/article/8cc02f2742d84833a052afbcc115d3a3
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2
Akademický článek
Blockade of crizotinib-induced BCL2 elevation in ALK-positive anaplastic large cell lymphoma triggers autophagy associated with cell death
Autor: Avedis Torossian, Nicolas Broin, Julie Frentzel, Camille Daugrois, Sarah Gandarillas, Talal Al Saati, Laurence Lamant, Pierre Brousset, Sylvie Giuriato, Estelle Espinos
Publikováno v: Haematologica, Vol 104, Iss 7 (2019)
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphomas are tumors that carry translocations involving the ALK gene at the 2p23 locus, leading to the expression of ALK tyrosine kinase fusion oncoproteins. Amongst hematologic maligna
Externí odkaz: https://doaj.org/article/1831c4e98edc4fd089548918768653f1
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5
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
Autor: Lara Gales, Camille Montersino, Marc Conti, Pierre Bories, Courtney D. DiNardo, Brandon Nicolay, Fabien Jourdan, Nicolas Broin, Mohsen Hosseini, Guillaume Cognet, Yves Gibon, Marie Sabatier, Tony Kaoma, Marina Konopleva, Lucille Stuani, Mathilde Gotanègre, Christian Recher, Laurent Fernando, Vera Pancaldi, Nathalie Poupin, Estelle Saland, Jean-Emmanuel Sarry, Joseph R. Marszalek, Andrei Turtoi, Thomas Farge, Feng Wang, Yves Collette, Laurent Le Cam, Madi Y. Cissé, Cédric Cassan, Alexis Hucteau, Claudie Bosc, Natalia Baran, Sebastien Ronseaux, Aliki Zavoriti, François Fenaille, Florence Castelli, Laetitia K. Linares, Evgenia Turtoi, Emeline Chu-Van, Martin Carroll, Pierre-Luc Mouchel, Mary A. Selak, Guillaume Cazals, Emeline Boet, Rémy Castellano, Floriant Bellvert, Norbert Vey, Clément Larrue, Koichi Takahashi, Ambrine Sahal, Sylvain Loric, Jean-Charles Portais
Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (5), pp.e20200924. ⟨10.1084/jem.20200924⟩
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (5), ⟨10.1084/jem.20200924⟩
The Journal of Experimental Medicine
Stuani et al. demonstrate that IDH mutant AML cells display an enhanced mitochondrial phenotype, which is not reversed by IDH mutant inhibitors. This study provides a scientific rationale for combinatory mitochondrial-targeted therapies to treat IDH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfb2b30f8b948c067d643d1119fbb0e
https://amu.hal.science/hal-03563454/file/jStuani_em_20200924.pdf
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6
Combinatory therapy targeting mitochondrial oxidative phosphorylation improves efficacy of IDH mutant inhibitors in acute myeloid leukemia
Autor: Floriant Bellvert, Camille Montersino, Pierre-Luc Mouchel, Brandon Nicolay, Guillaume Cazals, Laurent Fernando, Nicolas Broin, Jean-Charles Portais, Joe Marszalek, Clément Larrue, Norbert Vey, Sebastien Ronseaux, Thomas Farge, Jean-Emmanuel Sarry, Andrei Turtoi, Aliki Zavoriti, Tony Kaoma, Courtney D. DiNardo, Emeline Chu-Van, Claudie Bosc, Guillaume Cognet, Rémy Castellano, Héléna Boutzen, Cédric Cassan, Claire Calmettes, Florence Castelli, Marie Sabatier, Arnaud Pigneux, Evgenia Turtoi, Yves Collette, Martin Carroll, Yves Gibon, Emeline Boet, Laetitia K. Linares, Mathilde Gotanègre, Francois Fenaille, Laurent Le Cam, Lara Gales, Marc Conti, Nathalie Poupin, Mary A. Selak, Lucille Stuani, Andrew Futreal, Christian Recher, Marina Konopleva, Feng Wang, Estelle Saland, Mohsen Hosseini, Audrey Bidet, Kiyomi Morita, Natalia Baran, Koichi Takahashi, Sylvain Loric, Pierre Bories, Fabien Jourdan
Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, BCL-2 dependence and susceptibility to mitochondrial inhibitors in cance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55157cd88bc325916e6636c39f8f7b18
https://hal.archives-ouvertes.fr/hal-02935177
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7
IDH1 Mutation Enhances Catabolic Flexibility and Mitochondrial Dependencies to Favor Drug Resistance in Acute Myeloid Leukemia
Autor: Héléna Boutzen, Clément Larrue, Pierre Millard, Laurent Fernando, Laurent Le Cam, Laurie Gayte, Noémie Gadaud, Tony Kaoma, Pierre-Luc Mouchel, Evgenia Turtoi, Jean-Charles Portais, Nesrine Aroua, Justine Bertrand-Michel, Courtney Dinardo, Tony Lionel Palama, Yves Collette, Camille Montersino, Laure Tonini, Yves Gibon, Madi Y. Cissé, Cédric Cassan, Koichi Takahashi, Florence Castelli, Pierre Bories, Audrey Bidet, Joe Marszalek, Martin Carroll, Guillaume Cazals, Claire Calmettes, Arnaud Pigneux, Thomas Farge, Lucille Stuani, Feng Wang, Fabien Jourdan, Laetitia K. Linares, Mary A. Selak, Lara Gales, Andrew M. Futreal, Mathilde Gotanègre, Maud Heuillet, Kiyomi Morita, Jean-Emmanuel Sarry, Andrei Turtoi, Nicolas Broin, Christian Recher, Marina Konopleva, Mohsen Hosseini, Christophe Junot, Claudie Bosc, Emeline Chu-Van, Marine Fraisse, Nathalie Saint-Laurent, Lindsay Peyriga, Rémy Castellano, Estelle Saland, Natalia Baran, Norbert Vey, Frédéric Lopez, Floriant Bellvert, Marie Sabatier, Nathalie Poupin
Publikováno v: SSRN Electronic Journal.
Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. We hypothesized that key metabolic fluxes are selectively reprogrammed to maintain biosynthetic homeostasis and lower drug responses in IDH mutant acute myeloid leu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1ba1581b47f07f178516f5bad74221b
https://doi.org/10.2139/ssrn.3255557
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8
Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism
Autor: François Vergez, Marine Fraisse, Nicolas Broin, Thomas Farge, Robin L. Perry, Jean-Emmanuel Sarry, Audrey Sarry, Suzanne Tavitian, Stéphanie Cassant-Sourdy, Mayumi Sugita, Laetitia K. Linares, Jason S. Iacovoni, Claudie Bosc, Olivier Duchamp, Gwenn Danet-Desnoyers, Fabienne De Toni, Sarah J. Scotland, Y Barreira, Pierre Hirsch, Emmanuel Griessinger, Estelle Saland, Camille Montersino, Rémy Castellano, Héléna Boutzen, Nizar Serhan, Laurent Vallar, Martin Carroll, Christian Recher, Moshen Hosseini, Yves Collette, Lara Gales, François Delhommeau, Marion David, Marie-Laure Nicolau-Travers, Jean-Charles Portais, Nesrine Aroua, Lucille Stuani, Clément Larrue, Tony Kaoma, Tony Lionel Palama, Mary A. Selak, Barbara Garmy-Susini, Virginie Féliu
Publikováno v: Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2017, 7 (7), pp.716-735. ⟨10.1158/2159-8290.cd-16-0441⟩
Cancer Discovery, American Association for Cancer Research, 2017, 7 (7), pp.716-735. ⟨10.1158/2159-8290.CD-16-0441⟩
Cancer Discovery, 2017, 7 (7), pp.716-735. ⟨10.1158/2159-8290.cd-16-0441⟩
Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in vivo, we developed a clinically relevant chemotherapeutic approach treating pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c6cd90750845fe1c10175feb49744a
https://hal.archives-ouvertes.fr/hal-01608532
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