Blockade of crizotinib-induced BCL2 elevation in ALK-positive anaplastic large cell lymphoma triggers autophagy associated with cell death

Autor: Avedis Torossian, Nicolas Broin, Julie Frentzel, Camille Daugrois, Sarah Gandarillas, Talal Al Saati, Laurence Lamant, Pierre Brousset, Sylvie Giuriato, Estelle Espinos

Publikováno v: Haematologica, Vol 104, Iss 7 (2019)

Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphomas are tumors that carry translocations involving the ALK gene at the 2p23 locus, leading to the expression of ALK tyrosine kinase fusion oncoproteins. Amongst hematologic maligna

Externí odkaz: https://doaj.org/article/1831c4e98edc4fd089548918768653f1

Supplementary Methods and Supplementary Figures 1 through 18 from Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Autor: Jean-Emmanuel Sarry, Christian Récher, Martin Carroll, Gwenn Danet-Desnoyers, Mary Selak, François Vergez, Jean-Charles Portais, Barbara H. Garmy-Susini, François Delhommeau, Lara Gales, Tony Palama, Pierre Hirsch, Yara Barreira, Olivier Duchamp, Yves Collette, Emmanuel Griessinger, Rémy Castellano, Camille Montersino, Laetitia K. Linares, Jason Iacovoni, Laurent Vallar, Tony Kaoma, Suzanne Tavitian, Audrey Sarry, Nizar Serhan, Marion David, Nicolas Broin, Stéphanie Cassant-Sourdy, Marie-Laure Nicolau-Travers, Virginie Féliu, Héléna Boutzen, Clément Larrue, Sarah Scotland, Marine Fraisse, Lucille Stuani, Mayumi Sugita, Claudie Bosc, Robin Perry, Mohsen Hosseini, Nesrine Aroua, Fabienne de Toni, Estelle Saland, Thomas Farge

Supplementary Methods. Supplementary Figure S1. Clinical distributions of AML patients from TUH and 3 independent patient cohorts. Supplementary Figure S2. In vivo treatment with 60 mg/kg/d of cytarabine (AraC) given daily for 5 days induces a signif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2f0e8478dfe809f6b2b2680407008f
https://doi.org/10.1158/2159-8290.22532177.v1

Combinatory therapy targeting mitochondrial oxidative phosphorylation improves efficacy of IDH mutant inhibitors in acute myeloid leukemia

Autor: Floriant Bellvert, Camille Montersino, Pierre-Luc Mouchel, Brandon Nicolay, Guillaume Cazals, Laurent Fernando, Nicolas Broin, Jean-Charles Portais, Joe Marszalek, Clément Larrue, Norbert Vey, Sebastien Ronseaux, Thomas Farge, Jean-Emmanuel Sarry, Andrei Turtoi, Aliki Zavoriti, Tony Kaoma, Courtney D. DiNardo, Emeline Chu-Van, Claudie Bosc, Guillaume Cognet, Rémy Castellano, Héléna Boutzen, Cédric Cassan, Claire Calmettes, Florence Castelli, Marie Sabatier, Arnaud Pigneux, Evgenia Turtoi, Yves Collette, Martin Carroll, Yves Gibon, Emeline Boet, Laetitia K. Linares, Mathilde Gotanègre, Francois Fenaille, Laurent Le Cam, Lara Gales, Marc Conti, Nathalie Poupin, Mary A. Selak, Lucille Stuani, Andrew Futreal, Christian Recher, Marina Konopleva, Feng Wang, Estelle Saland, Mohsen Hosseini, Audrey Bidet, Kiyomi Morita, Natalia Baran, Koichi Takahashi, Sylvain Loric, Pierre Bories, Fabien Jourdan

Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, BCL-2 dependence and susceptibility to mitochondrial inhibitors in cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55157cd88bc325916e6636c39f8f7b18
https://hal.archives-ouvertes.fr/hal-02935177

Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism

Autor: François Vergez, Marine Fraisse, Nicolas Broin, Thomas Farge, Robin L. Perry, Jean-Emmanuel Sarry, Audrey Sarry, Suzanne Tavitian, Stéphanie Cassant-Sourdy, Mayumi Sugita, Laetitia K. Linares, Jason S. Iacovoni, Claudie Bosc, Olivier Duchamp, Gwenn Danet-Desnoyers, Fabienne De Toni, Sarah J. Scotland, Y Barreira, Pierre Hirsch, Emmanuel Griessinger, Estelle Saland, Camille Montersino, Rémy Castellano, Héléna Boutzen, Nizar Serhan, Laurent Vallar, Martin Carroll, Christian Recher, Moshen Hosseini, Yves Collette, Lara Gales, François Delhommeau, Marion David, Marie-Laure Nicolau-Travers, Jean-Charles Portais, Nesrine Aroua, Lucille Stuani, Clément Larrue, Tony Kaoma, Tony Lionel Palama, Mary A. Selak, Barbara Garmy-Susini, Virginie Féliu

Publikováno v: Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2017, 7 (7), pp.716-735. ⟨10.1158/2159-8290.cd-16-0441⟩
Cancer Discovery, American Association for Cancer Research, 2017, 7 (7), pp.716-735. ⟨10.1158/2159-8290.CD-16-0441⟩
Cancer Discovery, 2017, 7 (7), pp.716-735. ⟨10.1158/2159-8290.cd-16-0441⟩

Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in vivo, we developed a clinically relevant chemotherapeutic approach treating pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c6cd90750845fe1c10175feb49744a
https://hal.archives-ouvertes.fr/hal-01608532

Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites.

Autor: Bosc, Claudie, Broin, Nicolas, Fanjul, Marjorie, Saland, Estelle, Farge, Thomas, Courdy, Charly, Batut, Aurélie, Masoud, Rawand, Larrue, Clément, Skuli, Sarah, Espagnolle, Nicolas, Pagès, Jean-Christophe, Carrier, Alice, Bost, Frédéric, Bertrand-Michel, Justine, Tamburini, Jérôme, Récher, Christian, Bertoli, Sarah, Mansat-De Mas, Véronique, Manenti, Stéphane

Publikováno v: Nature Communications; 8/13/2020, Vol. 11 Issue 1, p1-14, 14p