Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis

Autor: Marie Ruch, Nicolas Brach, Roméric Galéa, Patrick Wagner, Gaëlle Blond

Publikováno v: Molecules, Vol 25, Iss 21, p 4976 (2020)

We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and

Externí odkaz: https://doaj.org/article/f182694021b749a39ee0df126bb91c36

Oxetanes and Oxetenes: Fused-Ring Derivatives

Autor: Krishna P. Kaliappan, Vincent Bizet, Nicolas Brach, Lénaic Rummler, Nicolas Blanchard

Publikováno v: Comprehensive Heterocyclic Chemistry IV ISBN: 9780128186565
Comprehensive Heterocyclic Chemistry IV
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier, 2021, ⟨10.1016/B978-0-12-818655-8.00150-5⟩

International audience; Fused and spiro-oxetanes, oxetenes and b-lactones are important classes of compounds that have found numerous applications in various areas of chemistry including medicinal chemistry and total synthesis of natural products. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13111e558fd287fdb746ccbe85e9b633
https://doi.org/10.1016/b978-0-12-818655-8.00150-5

Optimized Synthesis of 7-Azaindazole by a Diels–Alder Cascade and Associated Process Safety

Autor: Fabrice Gallou, Nicolas Blanchard, Vincent Le Fouler, Nicolas Brach, Vincent Bizet, Michael Parmentier, Corinne Bailly, Marian Lanz, Pascale Hoehn

Publikováno v: Organic Process Research and Development
Organic Process Research and Development, American Chemical Society, 2020, 24 (5), pp.776-786. ⟨10.1021/acs.oprd.0c00184⟩

International audience; Although pyrimidines are not among the most reactive partners in intramolecular inverse-electron demand [4ps+2ps] reactions with alkynes, they could be activated under mild and practical conditions, leading to fused nitrogen-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a285471dfc735e6dfcde93149513852
https://hal.archives-ouvertes.fr/hal-02991836