Table S1, Table S2, Table S3, Table S4, Figure S1Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7 from Efficacy of the Antibody–Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

Autor: Nathalie Corvaia, Eric Chetaille, Mariya Pavlyuk, Cyrille Dreyfus, Michel Perez, Alain Beck, Jean-Francois Haeuw, Thierry Champion, Nicolas Boute, Martine Malissard, Charlotte Beau-Larvor, Alain Robert, Noureddine Loukili, Matthieu Broussas, Barbara Akla

Table S1 shows expression of IGF1R on human tissues Table S2 shows expression of IGF1R on Tumor and Normal cells Table S3 shows DAR calculation Table S4 shows impact of W0101 on cell cycle Figure S1 shows the flowchart for selection of m208F2 Figure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7311e3db6a545594f7793dd543bb27d1
https://doi.org/10.1158/1535-7163.22510686.v1

Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

Autor: Nicolas Boute, Mariya Pavlyuk, Matthieu Broussas, Barbara Akla, Cyrille Dreyfus, Michel Perez, Charlotte Beau-Larvor, Thierry Champion, Alain Robert, Eric Chetaille, Alain Beck, Noureddine Loukili, Martine Malissard, Jean-François Haeuw, Nathalie Corvaia

Publikováno v: Molecular cancer therapeutics. 19(1)

The insulin-like growth factor type 1 receptor (IGF-1R) is important in tumorigenesis, and its overexpression occurs in numerous tumor tissues. To date, therapeutic approaches based on mAbs and tyrosine kinase inhibitors targeting IGF-1R have only sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc6f3c2fb7dc2acfcd49d88e3c04fd0
https://pubmed.ncbi.nlm.nih.gov/31594825

Abstract 3372: VISTA interaction with PSGL1, a likely VISTA receptor in tumors, is effectively disrupted by K0401-020 anti-VISTA antibody

Autor: Francisco Cruzalegui, Nathalie Corvaia, Nicolas Boute, Noureddine Loukili, Pierre Ferré, Celine Thuilliez, Martine Malissard, Olivier Delfour, Pierre Launay, Eric Chetaille, Thierry Champion, Alexandre Passioukov

Publikováno v: Cancer Research. 80:3372-3372

Background: VISTA (V-domain Ig suppressor of T cell Activation) is a transmembrane B7 family protein that is described as a negative checkpoint of T cell response. K01401-020 is a novel anti-VISTA antibody entering clinical trials (Loukili et al, AAC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b28d34880201bfd2d07b8dd4601ce94
https://doi.org/10.1158/1538-7445.am2020-3372

A New Anti-CXCR4 Antibody That Blocks the CXCR4/SDF-1 Axis and Mobilizes Effector Cells

Autor: Alain Beck, Charlotte Beau-Larvor, Christine Klinguer-Hamour, Liliane Goetsch, Sven Berger, Matthieu Broussas, Thomas Matthes, Thierry Champion, Alain Robert, Nathalie Corvaia, Nicolas Boute, Barbara Akla, Christian Bailly, Jean-François Haeuw, Charles Dumontet

Publikováno v: Molecular Cancer Therapeutics, Vol. 15, No 8 (2016) pp. 1890-1899
Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, 2016, 15, pp.1890-1899. ⟨10.1158/1535-7163.MCT-16-0041⟩
Molecular Cancer Therapeutics, American Association for Cancer Research, 2016, 15, pp.1890-1899. ⟨10.1158/1535-7163.MCT-16-0041⟩

The type IV C-X-C-motif chemokine receptor (CXCR4) is expressed in a large variety of human cancers, including hematologic malignancies, and this receptor and its ligand, stromal cell–derived factor-1 (SDF-1), play a crucial role in cancer progress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3899e858a708815717c620ef377724
https://archive-ouverte.unige.ch/unige:88986

A novel antagonist anti-cMet antibody with antitumor activities targeting both ligand-dependent and ligand-independent c-Met receptors

Autor: Alexandra, Gonzalez, Matthieu, Broussas, Charlotte, Beau-Larvor, Jean-François, Haeuw, Nicolas, Boute, Alain, Robert, Thierry, Champion, Alain, Beck, Christian, Bailly, Nathalie, Corvaïa, Liliane, Goetsch

Publikováno v: International journal of cancer. 139(8)

c-Met is a prototypic member of a sub-family of RTKs. Inappropriate c-Met activation plays a crucial role in tumor formation, proliferation and metastasis. Using a key c-Met dimerization assay, a set of 12 murine whole IgG1 monoclonal antibodies was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d50bf486e06f8bc563e3636932fcfd0
https://pubmed.ncbi.nlm.nih.gov/27144973