Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects

Autor: Edmone Dewaeles, Kévin Carvalho, Sandy Fellah, Jaewon Sim, Nihad Boukrout, Raphaelle Caillierez, Hariharan Ramakrishnan, Cynthia Van der Hauwaert, Jhenkruthi Vijaya Shankara, Nathalie Martin, Noura Massri, Agathe Launay, Joseph K. Folger, Clémentine de Schutter, Romain Larrue, Ingrid Loison, Marine Goujon, Matthieu Jung, Stéphanie Le Gras, Victoria Gomez-Murcia, Emilie Faivre, Julie Lemaire, Anne Garat, Nicolas Beauval, Patrice Maboudou, Viviane Gnemmi, Jean-Baptiste Gibier, Luc Buée, Corinne Abbadie, Francois Glowacki, Nicolas Pottier, Michael Perrais, Rodrigo A. Cunha, Jean-Sébastien Annicotte, Geoffroy Laumet, David Blum, Christelle Cauffiez

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)

Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induc

Externí odkaz: https://doaj.org/article/f322febb20a9426fac11bb1c684e29af

Assessment of Pb(II), Cd(II), and Al(III) Removal Capacity of Bacteria from Food and Gut Ecological Niches: Insights into Biodiversity to Limit Intestinal Biodisponibility of Toxic Metals

Autor: Fanny George, Séverine Mahieux, Catherine Daniel, Marie Titécat, Nicolas Beauval, Isabelle Houcke, Christel Neut, Delphine Allorge, Frédéric Borges, Gwénaël Jan, Benoît Foligné, Anne Garat

Publikováno v: Microorganisms, Vol 9, Iss 2, p 456 (2021)

Toxic metals (such as lead, cadmium, and, to a lesser extent, aluminum) are detrimental to health when ingested in food or water or when inhaled. By interacting with heavy metals, gut and food-derived microbes can actively and/or passively modulate (

Externí odkaz: https://doaj.org/article/0dce07a6346047dea64544be95d66677

Insights into the regulation of cellular Mn2+ homeostasis via TMEM165

Autor: Dorothée Vicogne, Nicolas Beauval, Zoé Durin, Delphine Allorge, Kateryna Kondratska, Aurélien Haustrate, Natasha Prevarskaya, Vladimir Lupashin, Dominique Legrand, François Foulquier

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, 2023, 1869 (6), pp.166717. ⟨10.1016/j.bbadis.2023.166717⟩

International audience; Golgi cation homeostasis is known to be crucial for many cellular processes including vesicular fusion events, protein secretion, as well as for the activity of Golgi glycosyltransferases and glycosidases. TMEM165 was identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9aa2fbf6f895ef7615df4622ff178a
https://hal.science/hal-04143894/document

Stability of trace element concentrations in frozen urine - Effect on different elements of more than 10 years at - 80 °C

Autor: Nicolas Beauval, Ariane Leroyer, Michael Hisbergues, Delphine Allorge, Patrice Maboudou, Mike Howsam, Catherine Nisse

Publikováno v: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 74

Analysis of urinary trace elements is widely used in Human Biology, especially in occupational and environmental biomonitoring. Collections of urine samples are of great interest for those studying trace elements but many of them are actually unused,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f702a00556f6d12160a102d20ca38d
https://pubmed.ncbi.nlm.nih.gov/36179463

Texture parameters of R2* maps are correlated with iron concentration and red blood cells count in clot analogs: A 7-T micro-MRI study

Autor: Gillian Gunning, Antonino Bongiovanni, Jean-Pierre Pruvo, Charlotte Cordonnier, Xavier Leclerc, Nicolas Beauval, Grégory Kuchcinski, Ray McCarthy, Martin Bretzner, Delphine Corseaux, Meryem Tardivel, Sophie Susen, Florent Auger, Renaud Lopes

Publikováno v: Journal of Neuroradiology. 47:306-311

Previous studies have suggested that mechanical revascularization in acute ischemic stroke (AIS) patients could be affected by clot histology. In this 7-T micro-MRI study, we used R2* relaxometry of clot analogs to evaluate the relationship between t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16273ed7058045658702b219b8618df7
https://doi.org/10.1016/j.neurad.2019.10.004