Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Nicolas Aznar"'
Autor:
François Virard, Stéphane Giraud, Mélanie Bonnet, Léa Magadoux, Laetitia Martin, Thuy Ha Pham, Najwa Skafi, Sophie Deneuve, Rita Frem, Bruno O. Villoutreix, Nawal Hajj Sleiman, Jonathan Reboulet, Samir Merabet, Vincent Chaptal, Cédric Chaveroux, Nader Hussein, Nicolas Aznar, Tanguy Fenouil, Isabelle Treilleux, Pierre Saintigny, Stéphane Ansieau, Serge Manié, Serge Lebecque, Toufic Renno, Isabelle Coste
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The quest for targeted therapies is critical in the battle against cancer. The RAS/MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous
Externí odkaz:
https://doaj.org/article/5f91f695de8442caa6ead3b1243c6294
Autor:
Lingxia Qiao, Saptarshi Sinha, Amer Ali Abd El‐Hafeez, I‐Chung Lo, Krishna K Midde, Tony Ngo, Nicolas Aznar, Inmaculada Lopez‐Sanchez, Vijay Gupta, Marilyn G Farquhar, Padmini Rangamani, Pradipta Ghosh
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 4, Pp n/a-n/a (2023)
Abstract Cancers represent complex autonomous systems, displaying self‐sufficiency in growth signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” growth factors (GFs): a poorly understood phenomenon. Usin
Externí odkaz:
https://doaj.org/article/fa7b3bde97544f3e97560e5c2c0d0fc4
Autor:
Guillaume Collin, Jean-Philippe Foy, Nicolas Aznar, Nicolas Rama, Anne Wierinckx, Pierre Saintigny, Alain Puisieux, Stéphane Ansieau
Publikováno v:
Cancers, Vol 15, Iss 3, p 973 (2023)
Reactive oxygen species (ROS) are considered to be the main drivers of inflammatory bowel disease. We investigated whether this permanent insult compels intestinal stem cells to develop strategies to dampen the deleterious effects of ROS. As an adver
Externí odkaz:
https://doaj.org/article/7328f30b724c4af1b6eebdecb4bdf23d
Autor:
Roumaïssa Gouasmi, Carole Ferraro-Peyret, Stéphane Nancey, Isabelle Coste, Toufic Renno, Cédric Chaveroux, Nicolas Aznar, Stéphane Ansieau
Publikováno v:
Cancers, Vol 14, Iss 11, p 2793 (2022)
The kynurenine pathway has been highlighted as a gatekeeper of immune-privileged sites through its ability to generate from tryptophan a set of immunosuppressive metabolic intermediates. It additionally constitutes an important source of cellular NAD
Externí odkaz:
https://doaj.org/article/82c2f5b6827a4338a23c4fd16c51a458
Autor:
Marie Piecyk, Mouna Triki, Pierre-Alexandre Laval, Helena Dragic, Laura Cussonneau, Joelle Fauvre, Cédric Duret, Nicolas Aznar, Toufic Renno, Serge N. Manié, Cédric Chaveroux, Carole Ferraro-Peyret
Publikováno v:
Metabolites, Vol 11, Iss 4, p 198 (2021)
Genetic alterations in non-small cell lung cancers (NSCLC) stimulate the generation of energy and biomass to promote tumor development. However, the efficacy of the translation process is finely regulated by stress sensors, themselves often controlle
Externí odkaz:
https://doaj.org/article/309028d82b7f441884b4a6bfa80e4c95
Autor:
Nicolas Aznar, Arjun Patel, Cristina C Rohena, Ying Dunkel, Linda P Joosen, Vanessa Taupin, Irina Kufareva, Marilyn G Farquhar, Pradipta Ghosh
Publikováno v:
eLife, Vol 5 (2016)
Loss of epithelial polarity impacts organ development and function; it is also oncogenic. AMPK, a key sensor of metabolic stress stabilizes cell-cell junctions and maintains epithelial polarity; its activation by Metformin protects the epithelial bar
Externí odkaz:
https://doaj.org/article/242bdc21d8c94924921c7a66668db1a9
Autor:
Nicolas Aznar, Krishna K Midde, Ying Dunkel, Inmaculada Lopez-Sanchez, Yelena Pavlova, Arthur Marivin, Jorge Barbazán, Fiona Murray, Ulrich Nitsche, Klaus-Peter Janssen, Karl Willert, Ajay Goel, Miguel Abal, Mikel Garcia-Marcos, Pradipta Ghosh
Publikováno v:
eLife, Vol 4 (2015)
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G pr
Externí odkaz:
https://doaj.org/article/af5395b5b53c4d27b63c1bcee1f12367
Autor:
Marie Piecyk, Mouna Triki, Pierre-Alexandre Laval, Cedric Duret, Joelle Fauvre, Laura Cussonneau, Christelle Machon, Jerôme Guitton, Nicolas Rama, Benjamin Gibert, Gabriel Ichim, Frederic Catez, Fleur Bourdelais, Sebastien Durand, Jean-Jacques Diaz, Isabelle Coste, Toufic Renno, Serge N Manié, Nicolas Aznar, Stephane Ansieau, Carole Ferraro-Peyret, Cedric Chaveroux
Nutrient availability is a key determinant of tumor cell behavior. While nutrient-rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance. Here, linkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f74bcf065ac1ac5fcd80c8dbd953542
https://doi.org/10.1101/2023.02.08.527626
https://doi.org/10.1101/2023.02.08.527626
Autor:
Laura Cussonneau, Toufic Renno, Nicolas Aznar, Marie Piecyk, Helena Dragic, Cédric Chaveroux, Cédric Duret, Serge N. Manie, Pierre-Alexandre Laval, Carole Ferraro-Peyret, Joelle Fauvre, Mouna Triki
Publikováno v:
Metabolites
Metabolites, 2021, 11 (4), ⟨10.3390/metabo11040198⟩
Volume 11
Issue 4
Metabolites, Vol 11, Iss 198, p 198 (2021)
Metabolites, MDPI, 2021, 11 (4), ⟨10.3390/metabo11040198⟩
Metabolites, 2021, 11 (4), ⟨10.3390/metabo11040198⟩
Volume 11
Issue 4
Metabolites, Vol 11, Iss 198, p 198 (2021)
Metabolites, MDPI, 2021, 11 (4), ⟨10.3390/metabo11040198⟩
International audience; Genetic alterations in non-small cell lung cancers (NSCLC) stimulate the generation of energy and biomass to promote tumor development. However, the efficacy of the translation process is finely regulated by stress sensors, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48abe5861a6e26eb555396bf2148b6c9
https://hal.science/hal-03194581/document
https://hal.science/hal-03194581/document
Autor:
Krishna Midde, I-Chung Lo, Pradipta Ghosh, Inmaculada Lopez-Sanchez, Saptarshi Sinha, Tony Ngo, Amer Ali Abd El-Hafeez, Vijay Gupta, Padmini Rangamani, Nicolas Aznar, Marilyn G. Farquhar, Lingxia Qiao
Cancers represent complex autonomous systems, displaying self-sufficiency in growth signaling. Autonomous growth is fueled by a cancer cell’s ability to ‘secrete-and-sense’ growth factors: a poorly understood phenomenon. Using an integrated sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f2cb155359294917a4e9bd25b2a6e2f
https://doi.org/10.1101/2021.03.18.436048
https://doi.org/10.1101/2021.03.18.436048