Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nicolas A. May"'
Autor:
Birgit Stallmeyer, Clara Bühlmann, Rytis Stakaitis, Ann-Kristin Dicke, Farah Ghieh, Luisa Meier, Ansgar Zoch, David MacKenzie MacLeod, Johanna Steingröver, Özlem Okutman, Daniela Fietz, Adrian Pilatz, Antoni Riera-Escamilla, Miguel J. Xavier, Christian Ruckert, Sara Di Persio, Nina Neuhaus, Ali Sami Gurbuz, Ahmet Şalvarci, Nicolas Le May, Kevin McEleny, Corinna Friedrich, Godfried van der Heijden, Margot J. Wyrwoll, Sabine Kliesch, Joris A. Veltman, Csilla Krausz, Stéphane Viville, Donald F. Conrad, Dónal O’Carroll, Frank Tüttelmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract piRNAs are crucial for transposon silencing, germ cell maturation, and fertility in male mice. Here, we report on the genetic landscape of piRNA dysfunction in humans and present 39 infertile men carrying biallelic variants in 14 different p
Externí odkaz:
https://doaj.org/article/f298226160c54693a03e5498d577cfea
Autor:
Adella Karam, Clarisse Delvallée, Alejandro Estrada-Cuzcano, Véronique Geoffroy, Jean-Baptiste Lamouche, Anne-Sophie Leuvrey, Elsa Nourisson, Julien Tarabeux, Corinne Stoetzel, Sophie Scheidecker, Louise Frances Porter, Emmanuelle Génin, Richard Redon, Florian Sandron, Anne Boland, Jean-François Deleuze, Nicolas Le May, Hélène Dollfus, Jean Muller
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8729 (2023)
Bardet–Biedl syndrome (BBS) is an autosomal recessive ciliopathy that affects multiple organs, leading to retinitis pigmentosa, polydactyly, obesity, renal anomalies, cognitive impairment, and hypogonadism. Until now, biallelic pathogenic variants
Externí odkaz:
https://doaj.org/article/2b873905703741e9b297d16106f54ccc
Autor:
Rayanne Damaj-Fourcade, Nicolas Meyer, Cathy Obringer, Nicolas Le May, Nadège Calmels, Vincent Laugel
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Cockayne syndrome is a rare condition that encompasses a very wide spectrum of clinical severity. Mutations upstream of a transposon called PiggyBac Transposable Element Derived 3 in intron 5 of the CSB/ERCC6 gene could bring about less severe forms
Externí odkaz:
https://doaj.org/article/f8f6efcefc73456a958ad9da37a80874
Autor:
Jérémy Sandoz, Zita Nagy, Philippe Catez, Gizem Caliskan, Sylvain Geny, Jean-Baptiste Renaud, Jean-Paul Concordet, Arnaud Poterszman, Laszlo Tora, Jean-Marc Egly, Nicolas Le May, Frédéric Coin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Chromatin structure plays a significant role in the regulation of gene expression. Here the authors show that TFIIH interacts with the histone acetyl transferase KAT2A and recruits the ATAC/hSAGA complexes to chromatin; and that loss of xeroderma pig
Externí odkaz:
https://doaj.org/article/c3b2c0ec8f5b4543bcc98340f8ba7994
Autor:
Ryan M. Sheridan, Frances S. Li, Erin D. Lucas, Heather D. Hickman, Thomas E. Morrison, Jay R. Hesselberth, Mary K. McCarthy, Beth A. Jirón Tamburini, Cormac J. Lucas, Kathryn S. Carpentier, Nicolas A. May, Glennys V. Reynoso, Bennett Davenport
While viremia in the vertebrate host is a major determinant of arboviral reservoir competency, transmission efficiency, and disease severity, immune mechanisms that control arboviral viremia are poorly defined. Here, we identify critical roles for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a1f4ecd8ef85d167f221cc1aab6d43
https://doi.org/10.1101/2021.06.10.447957
https://doi.org/10.1101/2021.06.10.447957
Autor:
Jean-Baptiste Renaud, Jérémy Sandoz, Jean-Paul Concordet, Philippe Catez, Sylvain Geny, Laszlo Tora, Gizem Caliskan, Arnaud Poterszman, Nicolas Le May, Jean-Marc Egly, Zita Nagy, Frédéric Coin
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-09270-2⟩
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-09270-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.1288. ⟨10.1038/s41467-019-09270-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-09270-2⟩
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-09270-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.1288. ⟨10.1038/s41467-019-09270-2⟩
The TFIIH subunit XPB is involved in combined Xeroderma Pigmentosum and Cockayne syndrome (XP-B/CS). Our analyses reveal that XPB interacts functionally with KAT2A, a histone acetyltransferase (HAT) that belongs to the hSAGA and hATAC complexes. XPB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2af59dd46589be04d58d71b39649911
https://hal.archives-ouvertes.fr/hal-03092036
https://hal.archives-ouvertes.fr/hal-03092036
True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Nucleotide excision repair (NER) is a major DNA repair pathway in eukaryotic cells. NER removes structurally diverse lesions such as pyrimidine dimers, arising upon UV irradiation or bulky chemical adducts, arising upon exposure to carcinogens and so
Externí odkaz:
https://doaj.org/article/02a40ff87cb04ad78f89b575a8ff55f0
Autor:
Nicolas Le May, Zeyni Mansuroglu, Psylvia Léger, Thibaut Josse, Guillaume Blot, Agnès Billecocq, Ramon Flick, Yves Jacob, Eliette Bonnefoy, Michèle Bouloy
Publikováno v:
PLoS Pathogens, Vol 4, Iss 1, p e13 (2008)
Rift Valley fever virus (RVFV) nonstructural protein NSs acts as the major determinant of virulence by antagonizing interferon beta (IFN-beta) gene expression. We demonstrate here that NSs interacts with the host protein SAP30, which belongs to Sin3A
Externí odkaz:
https://doaj.org/article/9b0c71d7d3274feb8a4452e85870730c
Autor:
Nadège Calmels, Vincent Laugel, Cathy Obringer, Nicolas Tuzin, Nicolas Le May, Sarah Baer, Peter B. Kang, Yvette van Ierland, Massimiliano Rossi, Masaya Kubota, Shehla Mohammed, Tiffany Busa, Myriam Durand, Caroline Michot, Geneviève Baujat, Godelieve Morel
Publikováno v:
European Journal of Medical Genetics, 64(1):104105. Elsevier Masson
Cockayne syndrome (CS) is a multisystem degenerative disorder divided in 3 overlapping subtypes, with a continuous phenotypic spectrum: CS2 being the most severe form, CS1 the classical form and CS3 the late-onset form. Failure to thrive and growth d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12aef08a6d54d9453f8886af7d55aab1
https://doi.org/10.1016/j.ejmg.2020.104105
https://doi.org/10.1016/j.ejmg.2020.104105
Autor:
Yu Fu, Andrii Bugai, Nicolas Le May, Maria Anastasina, Tuula A. Nyman, Jean-Marc Egly, Matjaz Barboric, Ilkka Julkunen, Sarah J. Butcher, Sampsa Matikainen, Janne Tynell, Suvi Kyttanen, Tiina Öhman, Denis E. Kainov, Sandra Söderholm, Lana Gaelings
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859:1440-1448
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee6051f3c035be20a903ba0ec29c148
https://doi.org/10.1016/j.bbagrm.2016.09.005
https://doi.org/10.1016/j.bbagrm.2016.09.005