Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Nicolas A Dumont"'
Autor:
Alyson Deprez, Ramy El-Jalbout, Anik Cloutier, Dany H. Gagnon, Andréa Gagnon Hamelin, Marie-Eve Mathieu, Thiffya Arabi Kugathasan, Nicolas A. Dumont, Anne Monique Nuyt, Thuy Mai Luu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Prematurity is associated with lower exercise capacity, which relies on the integrity of the cardiovascular, pulmonary, and skeletal muscle systems. Our animal model mimicking prematurity-associated conditions showed altered muscle compositi
Externí odkaz:
https://doaj.org/article/1830612550ec4530a47b0f8b7a968a93
Autor:
Talita C. Conte, Gilberto Duran-Bishop, Zakaria Orfi, Inès Mokhtari, Alyson Deprez, Isabelle Côté, Thomas Molina, Tae-Yeon Kim, Lydia Tellier, Marie-Pier Roussel, Damien Maggiorani, Basma Benabdallah, Severine Leclerc, Lara Feulner, Ornella Pellerito, Jean Mathieu, Gregor Andelfinger, Cynthia Gagnon, Christian Beauséjour, Serge McGraw, Elise Duchesne, Nicolas A. Dumont
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1 (DM1); however, the underlying molecular mechanism and the impact on the disease severity are still elusive. Here, we show using patients’ samples th
Externí odkaz:
https://doaj.org/article/72d4142afc3647a1818a01b7490a64b2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Muscle wasting in Duchenne Muscular Dystrophy is caused by myofiber fragility and poor regeneration that lead to chronic inflammation and muscle replacement by fibrofatty tissue. Our recent findings demonstrated that Resolvin-D2, a bioa
Externí odkaz:
https://doaj.org/article/8f034e07d71a4520a1d7c5f0f6a8741a
Autor:
Junio Dort, Zakaria Orfi, Paul Fabre, Thomas Molina, Talita C. Conte, Karine Greffard, Ornella Pellerito, Jean-François Bilodeau, Nicolas A. Dumont
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids delay muscle wasting in Duchenne Muscular Dystrophy by reducing inflammation; but also have harmful side effects. Here, the authors show that Resolvin-D2 is more effective than glucocorticoids in mitigating muscular dystrophy in mouse
Externí odkaz:
https://doaj.org/article/b677507e81964e6ba72b1bd475989757
Autor:
Suleen Raad, Anu David, Melanie Sagniez, Bastien Paré, Zakaria Orfi, Nicolas A. Dumont, Martin A. Smith, Christophe Faure
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/ade1e6c981e445ef838b06a17f766496
Publikováno v:
Open Biology, Vol 11, Iss 12 (2021)
Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also plays a key role in the coordination of skeletal muscle regeneration
Externí odkaz:
https://doaj.org/article/b0315130708e4c5a82d0751fa0635c9e
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Muscle regeneration is a closely regulated process that involves a variety of cell types such as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory cells. Among these different cell types, macrophages emerged
Externí odkaz:
https://doaj.org/article/e55e2f12ce8840eca94b51347afb1833
Autor:
Mathilde Soulez, Pierre‐Luc Tanguay, Florence Dô, Junio Dort, Colin Crist, Alexey Kotlyarov, Matthias Gaestel, Mathieu Ferron, Nicolas A. Dumont, Sylvain Meloche
Publikováno v:
Journal of Cellular Physiology. 237:2271-2287
The physiological functions and downstream effectors of the atypical mitogen-activated protein kinase extracellular signal-regulated kinase 3 (ERK3) remain to be characterized. We recently reported that mice expressing catalytically-inactive ERK3 (Ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3e5bc016bb5601aa9bbc43925ee056
https://doi.org/10.1002/jcp.30695
https://doi.org/10.1002/jcp.30695
Autor:
Claudia Dominici, Oscar D. Villarreal, Junio Dort, Emilie Heckel, Yu Chang Wang, Ioannis Ragoussis, Jean-Sebastien Joyal, Nicolas A. Dumont, Stéphane Richard
In skeletal muscle, muscle stem cells (MuSC) are the main cells responsible for regeneration upon injury. In diseased skeletal muscle, it would be therapeutically advantageous to replace defective MuSCs, or rejuvenate them with drugs to enhance their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ad314c017cb996b2e37a5db365b832
https://doi.org/10.7554/elife.84570.1
https://doi.org/10.7554/elife.84570.1
Publikováno v:
Bioscience Reports. 43
Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the MuSC niche, such as immune cells, play key roles to coordinate MuSC function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1face94fa03c7c201ceeb415c8a682b
https://doi.org/10.1042/bsr20220284
https://doi.org/10.1042/bsr20220284