Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nicolas Levoin"'
MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways
Autor:
Shoji F. Kenji, Keerthi Kurma, Brigitte Collet, Christelle Oblet, Laure Debure, Carmelo Di Primo, Laëtitia Minder, Franck Vérité, Yannic Danger, Mickael Jean, Aubin Penna, Nicolas Levoin, Patrick Legembre
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-11 (2022)
Abstract CD95 is a death receptor that can promote oncogenesis through molecular mechanisms that are not fully elucidated. Although the mature CD95 membrane receptor is considered to start with the arginine at position 17 after elimination of the sig
Externí odkaz:
https://doaj.org/article/48a077bb6c494189aee69ecb73c0915b
Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases
Autor:
Dabbugoddu Brahmaiah, Anagani Kanaka Durga Bhavani, Pasula Aparna, Nangunoori Sampath Kumar, Hélène Solhi, Rémy Le Guevel, Blandine Baratte, Thomas Robert, Sandrine Ruchaud, Stéphane Bach, Surender Singh Jadav, Chada Raji Reddy, Paul Mosset, Nicolas Gouault, Nicolas Levoin, René Grée
Publikováno v:
Molecules, Vol 27, Iss 19, p 6149 (2022)
Three series of our lead CLK1 inhibitor DB18 have been designed, synthetized and tested against CLKs and DYRK1A kinases. Their cytotoxicity was subsequently measured on seven representative cancer cell lines. Guided by docking experiments, we focused
Externí odkaz:
https://doaj.org/article/8f6310fc059c4f1d98e8bd66d3c3586f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its ligand CD95L brings to a next level its aggregation and triggers different signaling pathways, leading to cell motility, differentiation or cell death. This diversi
Externí odkaz:
https://doaj.org/article/3776074b1d384be3a5054b40252c84e0
Autor:
Frédéric Justaud, Hippolyte Paysant, Louis Bastien Weiswald, Abdelghani Jebahi, Marie Jouanne, Nicolas Elie, Anne Sophie Voisin-Chiret, Thierry Roisnel, Clément Orione, Nicolas Levoin, Laurent Poulain, René Grée
Publikováno v:
New Journal of Chemistry
New Journal of Chemistry, 2022, 46 (19), pp.9119-9127. ⟨10.1039/D1NJ05987D⟩
New Journal of Chemistry, 2022, 46 (19), pp.9119-9127. ⟨10.1039/D1NJ05987D⟩
International audience; The development of inhibitors of anti-apoptotic proteins, such as Mcl-1, is currently a very active area in the field of cancer research. One of the very first reported inhibitor of Mcl-1 was the molecule MIM1, but we have dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f1b51b186195d87bbb6f5278d46dd5
https://doi.org/10.1039/d1nj05987d
https://doi.org/10.1039/d1nj05987d
Autor:
Hippolyte Paysant, Jérôme Bignon, Marie Jouanne, Christophe Denoyelle, Assaad Nasr El Dine, Anne Sophie Voisin-Chiret, Louis Bastien Weiswald, Olivier Tasseau, Nicolas Elie, Siham Hedir, Frédéric Justaud, Thierry Roisnel, Ali Hachem, Emilie Brotin, Laurent Poulain, Fanny Roussi, René Grée, Ali Soulieman, Nicolas Levoin
Publikováno v:
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2021, 19 (41), pp.8968-8987. ⟨10.1039/d1ob01521d⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2021, 19 (41), pp.8968-8987. ⟨10.1039/d1ob01521d⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2021, 19 (41), pp.8968-8987. ⟨10.1039/d1ob01521d⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2021, 19 (41), pp.8968-8987. ⟨10.1039/d1ob01521d⟩
International audience; In the area of cancer research, the development of new and potent inhibitors of anti-apoptotic proteins is a very active and promising topic. The small molecule MIM1 has been reported earlier as one of the first selective inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d101b994a857dd58e56594e3c84c017c
https://doi.org/10.1039/d1ob01521d
https://doi.org/10.1039/d1ob01521d
Autor:
Vennu Narendar, Philippe Juin, A. K. D. Bhavani, Rémy Le Guével, Fabien Gautier, Appala Venkata Ramana Murthy, Nicolas Levoin, Nangunoori Sampath Kumar, René Grée, Chada Raji Reddy, Paul Mosset, Hélène Solhi, Pasula Aparna, Julie Roul
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2021, 52, pp.128390. ⟨10.1016/j.bmcl.2021.128390⟩
Bioorganic & Medicinal Chemistry Letters, 2021, 52, pp.128390. ⟨10.1016/j.bmcl.2021.128390⟩
International audience; A small library of new piperidine-triazole hybrids with 3-aryl isoxazole side chains has been designed and synthesized. Their cytotoxicity against a panel of seven cancer cell lines has been established. For the most promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae63b759b6b3265e31ade8013c76432d
https://hal.archives-ouvertes.fr/hal-03414697/document
https://hal.archives-ouvertes.fr/hal-03414697/document
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Frontiers media, 2020, 8, pp.314. ⟨10.3389/fcell.2020.00314⟩
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology, 2020, 8, pp.314. ⟨10.3389/fcell.2020.00314⟩
Frontiers in Cell and Developmental Biology, Frontiers media, 2020, 8, pp.314. ⟨10.3389/fcell.2020.00314⟩
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology, 2020, 8, pp.314. ⟨10.3389/fcell.2020.00314⟩
International audience; CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its ligand CD95L brings to a next level its aggregation and triggers different signaling pathways, leading to cell motility, differentiation or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb1e40edd9cb49024fe85978b499eee
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02862235
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02862235
Autor:
René Grée, Sophie Barillé-Nion, Fabien Gautier, Paul Mosset, Olivier Tasseau, Philippe Juin, Niharika Amireddy, Shasi V. Kalivendi, Nicolas Levoin
Publikováno v:
Medicinal Chemistry Research
Medicinal Chemistry Research, Springer Verlag, 2018, 27 (4), pp.1050-1065. ⟨10.1007/s00044-017-2127-z⟩
Medicinal Chemistry Research, 2018, 27 (4), pp.1050-1065. ⟨10.1007/s00044-017-2127-z⟩
Medicinal Chemistry Research, Springer Verlag, 2018, 27 (4), pp.1050-1065. ⟨10.1007/s00044-017-2127-z⟩
Medicinal Chemistry Research, 2018, 27 (4), pp.1050-1065. ⟨10.1007/s00044-017-2127-z⟩
A series of new benzyl-substituted hydroquinones has been prepared by short and flexible routes. Such molecules are simplified analogs of bioactive natural terpenes. Preliminary studies have established, for some of these derivatives, promising cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2871819bafd8342dc4dd0329d70b0501
https://doi.org/10.1007/s00044-017-2127-z
https://doi.org/10.1007/s00044-017-2127-z
Autor:
Patrick Legembre, Ha Thanh Nguyen, Jean-Philippe Guégan, Pierre van de Weghe, Nicolas Levoin, Daniel Best, Mickael Jean
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (21), pp.126669. ⟨10.1016/j.bmcl.2019.126669⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (21), pp.126669. ⟨10.1016/j.bmcl.2019.126669⟩
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (21), pp.126669. ⟨10.1016/j.bmcl.2019.126669⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (21), pp.126669. ⟨10.1016/j.bmcl.2019.126669⟩
International audience; Proceeding our effort to study protein-protein interaction between the death receptor CD95 and phospholipase PLCγ1, we present in the current work chameleon-like traits of peptidomimetic inhibitors. Minute analysis of the int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6440654ce8d4addb18bce2521534b3f
https://univ-rennes.hal.science/hal-02393634
https://univ-rennes.hal.science/hal-02393634
Autor:
Nicolas Levoin, Patrick Legembre, Amanda Poissonnier, Pierre van de Weghe, Ha Thanh Nguyen, Daniel Best, Mickael Jean, Pierre Vacher, Jean-Philippe Guégan, Florence Jouan
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩
The death receptor CD95 (also known as Fas) induces apoptosis through protein/protein association and the formation of the death-inducing signaling complex. On the other hand, in certain biological conditions, this receptor recruits different protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f808a922d1329477abc13c81e64d3f74
https://pubmed.ncbi.nlm.nih.gov/31301931
https://pubmed.ncbi.nlm.nih.gov/31301931