Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Nicolas, Willand"'
Autor:
Antoine Gedeon, Emilie Yab, Aurelia Dinut, Elodie Sadowski, Estelle Capton, Aurore Dreneau, Julienne Petit, Bruna Gioia, Catherine Piveteau, Kamel Djaout, Estelle Lecat, Anne Marie Wehenkel, Francesca Gubellini, Ariel Mechaly, Pedro M. Alzari, Benoît Deprez, Alain Baulard, Alexandra Aubry, Nicolas Willand, Stéphanie Petrella
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110967- (2024)
Summary: Antimicrobial resistance remains a persistent and pressing public health concern. Here, we describe the synthesis of original triazole-containing inhibitors targeting the DNA gyrase, a well-validated drug target for developing new antibiotic
Externí odkaz:
https://doaj.org/article/f2ede360f26a40f4bc420e0ea048c2c6
Autor:
Coline Plé, Heng-Keat Tam, Anais Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A. Kirchner, Parisa Moshfegh, Adrien Herledan, Andrea Herrmann, Benoit Deprez, Nicolas Willand, Attilio Vittorio Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of it
Externí odkaz:
https://doaj.org/article/2d5e83c99b5c4265bf969d47fed84ba5
Autor:
Francesca Ruggieri, Philippe Hance, Bruna Gioia, Alexandre Biela, Pascal Roussel, Jean-Louis Hilbert, Nicolas Willand
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 771 (2023)
Sesquiterpene lactones (STLs) are a large group of terpenoids most commonly found in plants of the Asteraceae family, e.g., in chicory plants, displaying a wide range of interesting biological activities. However, further studies on the biological po
Externí odkaz:
https://doaj.org/article/4f38fdd181ba421ba0b9a173a0f4dfc6
Autor:
Salia Tangara, Léo Faïon, Catherine Piveteau, Frédéric Capet, Romain Godelier, Marion Michel, Marion Flipo, Benoit Deprez, Nicolas Willand, Baptiste Villemagne
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 413 (2023)
The concept of privileged structure has been used as a fruitful approach for the discovery of novel biologically active molecules. A privileged structure is defined as a semi-rigid scaffold able to display substituents in multiple spatial directions
Externí odkaz:
https://doaj.org/article/457540ee79dc4ef9b38bd6f202d0cd9c
Autor:
Léo Faïon, Kamel Djaout, Catalin Pintiala, Catherine Piveteau, Florence Leroux, Alexandre Biela, Stéphanie Slupek, Rudy Antoine, Monika Záhorszká, Francois-Xavier Cantrelle, Xavier Hanoulle, Jana Korduláková, Benoit Deprez, Nicolas Willand, Alain R. Baulard, Marion Flipo
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 335 (2023)
Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is responsible for the death of 1.5 million people each year and the number of bacteria resistant to the standard regimen is constantly increasing. This highlights the need to discove
Externí odkaz:
https://doaj.org/article/8f8af7ff2c8049dca93bfab59dd0da06
Autor:
Evelien Wynendaele, Christophe Furman, Bartosz Wielgomas, Per Larsson, Eelko Hak, Thomas Block, Serge Van Calenbergh, Nicolas Willand, Michal Markuszewski, Luke R. Odell, Gerrit J. Poelarends, Bart De Spiegeleer
Publikováno v:
Medicine in Drug Discovery, Vol 12, Iss , Pp 100107- (2021)
Due to the expanding and ageing world population, the importance and use of medicines is expected to increase. However, this will lead to a greater impact on the ecosystem and our health in the long term.The concept of sustainability is rather slowly
Externí odkaz:
https://doaj.org/article/5a33ad31471a408795ab5e204a5d6c7d
Autor:
Kevin Antraygues, Nina Compagne, Francesca Ruggieri, Kamel Djaout, Zainab Edoo, Maxime Eveque, Léo Faïon, Bruna Gioia, Salia Tangara, Anais Vieira Da Cruz, Baptiste Villemagne, Marion Flipo, Alain Baulard, Nicolas Willand
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 388 (2022)
The restrictions posed by the COVID-19 pandemic obliged the French Society for Medicinal Chemistry (Société de chimie thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) to organize their joint autumn symposi
Externí odkaz:
https://doaj.org/article/f47136f0cbd64212844c0704ce3808b7
Autor:
Sushovan Dam, Salia Tangara, Claire Hamela, Theo Hattabi, Léo Faïon, Paul Carre, Rudy Antoine, Adrien Herledan, Florence Leroux, Catherine Piveteau, Maxime Eveque, Marion Flipo, Benoit Deprez, Laurent Kremer, Nicolas Willand, Baptiste Villemagne, Ruben C. Hartkoorn
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16651-16664. ⟨10.1021/acs.jmedchem.2c01493⟩
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16651-16664. ⟨10.1021/acs.jmedchem.2c01493⟩
International audience; It is critical that novel classes of antituberculosis drugs are developed to combat the increasing burden of infections by multidrug-resistant strains. To identify such a novel class of antibiotics, a chemical library of uniqu
Autor:
Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo, Nicolas Willand
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2023, 256, pp.115413. ⟨10.1016/j.ejmech.2023.115413⟩
European Journal of Medicinal Chemistry, 2023, 256, pp.115413. ⟨10.1016/j.ejmech.2023.115413⟩
International audience; Antimicrobial resistance (AMR) is a major public health issue, causing 5 million deaths per year. Without any action plan, AMR will be in a near future the leading cause of death ahead of cancer. AMR comes from the ability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6701d9007286f34c49758179096ee3b7
https://hal.science/hal-04093378
https://hal.science/hal-04093378
Autor:
Benoit Deprez, Damien Bosc, Julie Charton, Cyril Couturier, Rebecca Deprez-Poulain, Marion Flipo, Florence Leroux, Baptiste Villemagne, Nicolas Willand
Publikováno v:
Molecules, Vol 26, Iss 19, p 6083 (2021)
Chemical biology and drug discovery are two scientific activities that pursue different goals but complement each other. The former is an interventional science that aims at understanding living systems through the modulation of its molecular compone
Externí odkaz:
https://doaj.org/article/3139cdf061794c5db887520979edb00b