Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Nicolas, Tapon"'
Phosphorylation‐linked complex profiling identifies assemblies required for Hippo signal integration
Autor:
Federico Uliana, Rodolfo Ciuffa, Ranjan Mishra, Andrea Fossati, Fabian Frommelt, Sabrina Keller, Martin Mehnert, Eivind Salmorin Birkeland, Frank van Drogen, Nevena Srejic, Matthias Peter, Nicolas Tapon, Ruedi Aebersold, Matthias Gstaiger
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 4, Pp 1-25 (2023)
Abstract While several computational methods have been developed to predict the functional relevance of phosphorylation sites, experimental analysis of the interdependency between protein phosphorylation and Protein–Protein Interactions (PPIs) rema
Externí odkaz:
https://doaj.org/article/87d8299e1ad24511acc6e8b026e4e491
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Tissues contain diverse cell populations that, together, make up physiologically functional units. A remarkable example is the animal epidermis, where neuronal and non-neuronal cells intermingle to allow somatosensory perception. In the peripheral ne
Externí odkaz:
https://doaj.org/article/ac739aee280943df842191a25a12a846
Autor:
M. Teresa Bertran, Stéphane Mouilleron, Yanxiang Zhou, Rakhi Bajaj, Federico Uliana, Ganesan Senthil Kumar, Audrey van Drogen, Rebecca Lee, Jennifer J. Banerjee, Simon Hauri, Nicola O’Reilly, Matthias Gstaiger, Rebecca Page, Wolfgang Peti, Nicolas Tapon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex a
Externí odkaz:
https://doaj.org/article/6895486193a040a6ada179998498e708
Autor:
Yavuz Kulaberoglu, Kui Lin, Maxine Holder, Zhongchao Gai, Marta Gomez, Belul Assefa Shifa, Merdiye Mavis, Lily Hoa, Ahmad A. D. Sharif, Celia Lujan, Ewan St. John Smith, Ivana Bjedov, Nicolas Tapon, Geng Wu, Alexander Hergovich
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how
Externí odkaz:
https://doaj.org/article/057c5004ddb54609858a2e780a18b291
Autor:
Alexander D Fulford, Maxine V Holder, David Frith, Ambrosius P Snijders, Nicolas Tapon, Paulo S Ribeiro
Publikováno v:
eLife, Vol 8 (2019)
Hippo signalling integrates diverse stimuli related to epithelial architecture to regulate tissue growth and cell fate decisions. The Hippo kinase cascade represses the growth-promoting transcription co-activator Yorkie. The FERM protein Expanded is
Externí odkaz:
https://doaj.org/article/8d1bbbbbdf9744d89e616afa003fad2b
Autor:
Alexander D. Fulford, Leonie Enderle, Jannette Rusch, Didier Hodzic, Maxine V. Holder, Alex Earl, Robin Hyunseo Oh, Nicolas Tapon, Helen McNeill
Publikováno v:
Journal of Cell Biology. 222
The Hippo pathway is a conserved and critical regulator of tissue growth. The FERM protein Expanded is a key signaling hub that promotes activation of the Hippo pathway, thereby inhibiting the transcriptional co-activator Yorkie. Previous work identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d11bfa4f2d7e0198b784d1fd6b8854d1
https://doi.org/10.1083/jcb.202204059
https://doi.org/10.1083/jcb.202204059
Autor:
Federica Mangione, Joshua Titlow, Catherine Maclachlan, Michel Gho, Ilan Davis, Lucy Collinson, Nicolas Tapon
The epidermis is equipped with specialized mechanosensory organs that enable the detection of tactile stimuli. Here, by examining the differentiation of the tactile bristles, mechanosensory organs decorating the Drosophila adult epidermis, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e27a4af63bc5038b2f659307bfaaf3
Autor:
Jennifer J Banerjee, Birgit L Aerne, Maxine V Holder, Simon Hauri, Matthias Gstaiger, Nicolas Tapon
Publikováno v:
eLife, Vol 6 (2017)
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. th
Externí odkaz:
https://doaj.org/article/b1c33b3864b7463aa607b906588ff5c7
Autor:
Federico Uliana, Rodolfo Ciuffa, Ranjan Mishra, Andrea Fossati, Fabian Frommelt, Martin Mehnert, Eivind Salmorin Birkeland, Matthias Peter, Nicolas Tapon, Ruedi Aebersold, Matthias Gstaiger
Cellular signaling relies on the temporal and spatial control of the formation of transient protein complexes by post-translational modifications, most notably by phosphorylation. While several computational methods have been developed to predict the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fef5154cd2f5c7628d6dd5f8c5b536f1
https://doi.org/10.1101/2022.03.13.484137
https://doi.org/10.1101/2022.03.13.484137
Autor:
David J. Barry, Maxine V. Holder, Anne Weston, Lucy M. Collinson, Eunice H Y Chan, Nicolas Tapon, Birgit L. Aerne, Yanxiang Zhou
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
Development (Cambridge, England), 2021, 148 (20), ⟨10.1242/dev.199731⟩
article-version (VoR) Version of Record
Development (Cambridge, England), 2021, 148 (20), ⟨10.1242/dev.199731⟩
Cell-cell junctions are dynamic structures that maintain cell cohesion and shape in epithelial tissues. During development, junctions undergo extensive rearrangements to drive the epithelial remodelling required for morphogenesis. This is particularl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e462571e67cfc2ab7584f6994ee342d
http://europepmc.org/articles/PMC8572004
http://europepmc.org/articles/PMC8572004