Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Nicolas, Singewald"'
Autor:
Simone B. Sartori, Thomas M. V. Keil, Kai K. Kummer, Conor P. Murphy, Ozge Gunduz-Cinar, Michaela Kress, Karl Ebner, Andrew Holmes, Nicolas Singewald
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The ventromedial prefrontal cortex (vmPFC; rodent infralimbic cortex (IL)), is posited to be an important locus of fear extinction-facilitating effects of the dopamine (DA) bio-precursor, L-DOPA, but this hypothesis remains to be formally te
Externí odkaz:
https://doaj.org/article/f6ceed42e2384d5bb6dbc4dc2f88ba60
Autor:
Nadine J. Ortner, Anupam Sah, Enrica Paradiso, Josef Shin, Strahinja Stojanovic, Niklas Hammer, Maria Haritonova, Nadja T. Hofer, Andrea Marcantoni, Laura Guarina, Petronel Tuluc, Tamara Theiner, Florian Pitterl, Karl Ebner, Herbert Oberacher, Emilio Carbone, Nadia Stefanova, Francesco Ferraguti, Nicolas Singewald, Jochen Roeper, Jörg Striessnig
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Germline de novo missense variants of the CACNA1D gene, encoding the pore-forming α1 subunit of Cav1.3 L-type Ca2+ channels (LTCCs), have been found in patients with neurodevelopmental and endocrine dysfunction, but their disease-causing potential i
Externí odkaz:
https://doaj.org/article/6c217573f67344608c7a051a8ed2797f
Autor:
Predrag Kalaba, Katharina Pacher, Philip John Neill, Vladimir Dragacevic, Martin Zehl, Judith Wackerlig, Michael Kirchhofer, Simone B. Sartori, Hubert Gstach, Shima Kouhnavardi, Anna Fabisikova, Matthias Pillwein, Francisco Monje-Quiroga, Karl Ebner, Alexander Prado-Roller, Nicolas Singewald, Ernst Urban, Thierry Langer, Christian Pifl, Jana Lubec, Johann Jakob Leban, Gert Lubec
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1415 (2023)
The high structural similarity, especially in transmembrane regions, of dopamine, norepinephrine, and serotonin transporters, as well as the lack of all crystal structures of human isoforms, make the specific targeting of individual transporters rath
Externí odkaz:
https://doaj.org/article/206825143bfe4497bebe4460b140ad5d
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
The hunger hormone ghrelin has been implicated in the modulation of anxiety- and fear-related behaviors in rodents and humans, while its dysregulation may be associated with psychiatric illness. Along these lines, the ghrelin system has been suggeste
Externí odkaz:
https://doaj.org/article/22f6e5fa96704631b1a24a5d599bb82c
Autor:
Nigel Whittle, Jonathan Fadok, Kathryn P. MacPherson, Robin Nguyen, Paolo Botta, Steffen B. E. Wolff, Christian Müller, Cyril Herry, Philip Tovote, Andrew Holmes, Nicolas Singewald, Andreas Lüthi, Stéphane Ciocchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impa
Externí odkaz:
https://doaj.org/article/e7f5a40092e743959f493ea9a98ded5d
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Sleep disturbances are a common complaint of anxiety patients and constitute a hallmark feature of post-traumatic stress disorder (PTSD). Emerging evidence suggests that poor sleep is not only a secondary symptom of anxiety- and trauma-relat
Externí odkaz:
https://doaj.org/article/761b8f8d93844bb1bd67bb3a367b3968
Autor:
Anupam Sah, Sinead Rooney, Maria Kharitonova, Simone B. Sartori, Susanne A. Wolf, Nicolas Singewald
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13052 (2022)
Neuroinflammation is discussed to play a role in specific subgroups of different psychiatric disorders, including anxiety disorders. We have previously shown that a mouse model of trait anxiety (HAB) displays enhanced microglial density and phagocyti
Externí odkaz:
https://doaj.org/article/c33f2f70857049d9bb347f6fc965fea3
Autor:
Malik Galijašević, Ruth Steiger, Milovan Regodić, Michaela Waibel, Patrick Julian David Sommer, Astrid Ellen Grams, Nicolas Singewald, Elke Ruth Gizewski
Publikováno v:
Frontiers in Human Neuroscience, Vol 15 (2021)
Introduction: Various functional neuroimaging studies help to better understand the changes in brain activity during meditation. The purpose of this study was to investigate how brain energy metabolism changes during focused attention meditation (FAM
Externí odkaz:
https://doaj.org/article/24348384fe474ec2bbf4a25d61b054f0
Autor:
Elke R. Gizewski, Ruth Steiger, Michaela Waibel, Sergiy Pereverzyev, Patrick J. D. Sommer, Christian Siedentopf, Astrid E. Grams, Lukas Lenhart, Nicolas Singewald
Publikováno v:
Brain and Behavior, Vol 11, Iss 1, Pp n/a-n/a (2021)
Abstract Background Meditation is increasingly attracting interest among neuroimaging researchers for its relevance as a cognitive enhancement technique and several cross‐sectional studies have indicated cerebral changes. This longitudinal study ap
Externí odkaz:
https://doaj.org/article/2f76da24078245ff90b7b7eab25bad61
Autor:
Karl Ebner, Simone B. Sartori, Rita Murau, Fabian Kopel, Predrag Kalaba, Vladimir Dragačević, Johann J. Leban, Nicolas Singewald, Mario Engelmann, Gert Lubec
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 506 (2022)
Previous studies have shown that atypical dopamine-transporter-inhibitors such as modafinil and its analogues modify behavioral and cognitive functions in rodents. Here, we tested potential promnestic effects of the novel, more dopamine-transporter s
Externí odkaz:
https://doaj.org/article/38f268bfe83643329910e4eb0788f786