Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Nicolas, Masurier"'
Autor:
Hesham Haffez, Nosaiba A. Elsayed, Marwa F. Ahmed, Samar S. Fatahala, Eman F. Khaleel, Rehab Mustafa Badi, Eslam B. Elkaeed, Mahmoud A. El Hassab, Sherif F. Hammad, Wagdy M. Eldehna, Nicolas Masurier, Radwan El-Haggar
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Significant advancements have been made in the domain of targeted anticancer therapy for the management of malignancies in recent times. VEGFR-2 is characterised by its pivotal involvement in angiogenesis and subsequent mechanisms that promote tumour
Externí odkaz:
https://doaj.org/article/8fcc8ea833f943b4862f2890cfe139e0
Autor:
Ibrahim H. Eissa, Radwan El-Haggar, Mohammed A. Dahab, Marwa F. Ahmed, Hazem A. Mahdy, Reem I. Alsantali, Alaa Elwan, Nicolas Masurier, Samar S. Fatahala
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1587-1599 (2022)
A novel series of 2-thioacetamide linked benzoxazole-benzamide conjugates 1–15 was designed as potential inhibitors of the vascular endothelial growth factor receptor-2 (VEGFR-2). The prepared compounds were evaluated for their potential antitumor
Externí odkaz:
https://doaj.org/article/df00a10607564622a1dbea3897e95ec3
Autor:
Paul Le Baccon-Sollier, Yohan Malki, Morgane Maye, Lamiaa M. A. Ali, Laure Lichon, Pierre Cuq, Laure-Anaïs Vincent, Nicolas Masurier
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 935-949 (2020)
A series of 19 novel pyrido-imidazodiazepinones, with modulations of positions 2, 3 and 4 of the diazepine ring were synthesised and screened for their in vitro cytotoxic activities against two melanoma cell lines (A375 and MDA-MB-435) and for their
Externí odkaz:
https://doaj.org/article/6f35928d0f274a598d4cc9b50e2d5395
Autor:
Henriette Bosson-Vanga, Nicolas Primas, Jean-François Franetich, Catherine Lavazec, Lina Gomez, Kutub Ashraf, Maurel Tefit, Valérie Soulard, Nathalie Dereuddre-Bosquet, Roger Le Grand, Mélanie Donnette, Romain Mustière, Nadia Amanzougaghene, Shahin Tajeri, Peggy Suzanne, Aurélie Malzert-Fréon, Sylvain Rault, Patrice Vanelle, Sébastien Hutter, Anita Cohen, Georges Snounou, Pierre Roques, Nadine Azas, Prisca Lagardère, Vincent Lisowski, Nicolas Masurier, Michel Nguyen, Lucie Paloque, Françoise Benoit-Vical, Pierre Verhaeghe, Dominique Mazier
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Human malaria infection begins with a one-time asymptomatic liver stage followed by a cyclic symptomatic blood stage. For decades, the research for novel antimalarials focused on the high-throughput screening of molecules that only targeted
Externí odkaz:
https://doaj.org/article/b8042b3d70524640b19a2ebd49c5a820
Autor:
Prisca Lagardère, Romain Mustière, Nadia Amanzougaghene, Sébastien Hutter, Jean-François Franetich, Nadine Azas, Patrice Vanelle, Pierre Verhaeghe, Nicolas Primas, Dominique Mazier, Nicolas Masurier, Vincent Lisowski
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 820 (2022)
Malaria remains one of the major health problems worldwide. The increasing resistance of Plasmodium to approved antimalarial drugs requires the development of novel antiplasmodial agents that can effectively prevent and/or treat this disease. Based o
Externí odkaz:
https://doaj.org/article/dd8dfb90be544685a247478be7fb2753
Recent advances in aza Friedel–Crafts reaction: strategies for achiral and stereoselective synthesis
Autor:
Ameni HADJ MOHAMED, Nicolas MASURIER
Publikováno v:
Organic Chemistry Frontiers. 10:1847-1866
The aza-Friedel–Crafts (aza-FC) reaction is a very powerful tool for forming C–C and C–N bonds, based on an acid-catalyzed addition of electron-rich aromatic compounds to imines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af22a488001c91eff4e0979fdcbb1c10
https://doi.org/10.1039/d2qo02018a
https://doi.org/10.1039/d2qo02018a
Autor:
Marion Peyressatre, Dominique Patomo Arama, Arthur Laure, Juan A. González-Vera, Morgan Pellerano, Nicolas Masurier, Vincent Lisowski, May C. Morris
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
CDK5/p25 kinase plays a major role in neuronal functions, and is hyperactivated in several human cancers including glioblastoma and neurodegenerative pathologies such as Alzheimer's and Parkinson's. CDK5 therefore constitutes an attractive pharmacolo
Externí odkaz:
https://doaj.org/article/914420937d754a1d94fae9a9b77bb833
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 234 (2022)
With the development of 68Ga and 177Lu radiochemistry, theranostic approaches in modern nuclear medicine enabling patient-centered personalized medicine applications have been growing in the last decade. In conjunction with the search for new relevan
Externí odkaz:
https://doaj.org/article/bd96e5a1e0c8489d839be92a954b011f
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 35 (2021)
Thienopyrimidines are widely represented in the literature, mainly due to their structural relationship with purine base such as adenine and guanine. This current review presents three isomers—thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and
Externí odkaz:
https://doaj.org/article/15e31d070e4f48af98af91eaf7f4a749
Autor:
Romain Mustière, Prisca Lagardère, Sébastien Hutter, Viviana Dell’Orco, Nadia Amanzougaghene, Shahin Tajeri, Jean-François Franetich, Sophie Corvaisier, Marc Since, Aurélie Malzert-Fréon, Nicolas Masurier, Vincent Lisowski, Pierre Verhaeghe, Dominique Mazier, Nadine Azas, Patrice Vanelle, Nicolas Primas
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2022, 241, pp.114619. ⟨10.1016/j.ejmech.2022.114619⟩
European Journal of Medicinal Chemistry, 2022, 241, pp.114619. ⟨10.1016/j.ejmech.2022.114619⟩
International audience; Gamhepathiopine (also known as M1), is a multi-stage acting antiplasmodial 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one hydrochloride that was first described in 2015. The development of this compound is limited by poor m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bfd963e0e1116d6ce6680442b337fa
https://hal.science/hal-03737417
https://hal.science/hal-03737417
