Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Nicolas, Levy"'
Autor:
Déborah Cardoso, Solenn Guilbert, Philippe Guigue, Aurélie Carabalona, Karim Harhouri, Cécile Peccate, Johana Tournois, Zoheir Guesmia, Lino Ferreira, Catherine Bartoli, Nicolas Levy, Laurence Colleaux, Xavier Nissan, Antoine Muchir
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-14 (2024)
Abstract Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder associated with features of accelerated aging. HGPS is an autosomal dominant disease caused by a de novo mutation of LMNA gene, encoding A-type lamins, resulti
Externí odkaz:
https://doaj.org/article/dc9bc6f3476e46378df90ad4de499f20
Autor:
Imen Nabouli, Asma Chikhaoui, Houcemeddine Othman, Sahar Elouej, Meriem Jones, Arnaud Lagarde, Meriem Ben Rekaya, Olfa Messaoud, Mohamed Zghal, Valerie Delague, Nicolas Levy, Annachiara De Sandre-Giovannoli, Sonia Abdelhak, Houda Yacoub-Youssef
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Xeroderma Pigmentosum (XP) is a rare genetic disorder affecting the nucleotide excision repair system (NER). It is characterized by an extreme sensitivity to sunlight that induces cutaneous disorders such as severe sunburn, freckling and cancers. In
Externí odkaz:
https://doaj.org/article/11ab2c55985a43ec9f2dd01bbfa4aed3
Autor:
Marine Paci, Razan Elkhatib, Guy Longepied, Patrice Bourgeois, Pierre F. Ray, Nicolas Levy, Michael J. Mitchell, Catherine Metzler-Guillemain
Publikováno v:
Basic and Clinical Andrology, Vol 28, Iss 1, Pp 1-7 (2018)
Résumé La lamina nucléaire (LN) est un réseau de filaments protéiques, composé essentiellement de lamines, situé entre la membrane nucléaire interne et la chromatine. La LN est un composant de l’enveloppe nucléaire, interagit avec une larg
Externí odkaz:
https://doaj.org/article/d71235111b8a40a9aadb229aa5276291
Autor:
Alice-Anaïs Varlet, Camille Desgrouas, Cécile Jebane, Nathalie Bonello-Palot, Patrice Bourgeois, Nicolas Levy, Emmanuèle Helfer, Noémie Dubois, René Valero, Catherine Badens, Sophie Beliard
Publikováno v:
Cells, Vol 11, Iss 1, p 50 (2021)
Many proteins are causative for inherited partial lipodystrophies, including lamins, the essential constituents of the nuclear envelope scaffold called the lamina. By performing high throughput sequencing on a panel of genes involved in lipodystrophi
Externí odkaz:
https://doaj.org/article/672b201c4aeb42159b616e0dc7d6ae3b
Autor:
Asma Chikhaoui, Sahar Elouej, Imen Nabouli, Meriem Jones, Arnaud Lagarde, Meriem Ben Rekaya, Olfa Messaoud, Yosr Hamdi, Mohamed Zghal, Valerie Delague, Nicolas Levy, Annachiara De Sandre-Giovannoli, Sonia Abdelhak, Houda Yacoub-Youssef
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder due to a defect in the nucleotide excision repair (NER) DNA repair pathway, characterized by severe sunburn development of freckles, premature skin aging, and susceptibility to develop
Externí odkaz:
https://doaj.org/article/1096c163093a4f33ae06d009de8bb509
Autor:
Elena Gargaun, Sestina Falcone, Guilhem Solé, Julien Durigneux, Andoni Urtizberea, Jean Marie Cuisset, Sofia Benkhelifa-Ziyyat, Laura Julien, Anne Boland, Florian Sandron, Vincent Meyer, Jean François Deleuze, David Salgado, Jean-Pierre Desvignes, Christophe Béroud, Anatole Chessel, Alexia Blesius, Martin Krahn, Nicolas Levy, France Leturcq, France Pietri-Rouxel
Publikováno v:
Biomedicines, Vol 9, Iss 2, p 219 (2021)
In skeletal muscle, long noncoding RNAs (lncRNAs) are involved in dystrophin protein stabilization but also in the regulation of myocytes proliferation and differentiation. Hence, they could represent promising therapeutic targets and/or biomarkers f
Externí odkaz:
https://doaj.org/article/968c00f1b0d148c5bfa7adb3b5474094
Autor:
Nicolas Levy, Sylvia Eiler, Karine Pradeau-Aubreton, Benoit Maillot, François Stricher, Marc Ruff
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Flexible or disordered domains often hinder the purification of proteins involved in functional interactions. Here the authors describe an approach that enables the production of stable and functional complexes of otherwise unstable proteins in quant
Externí odkaz:
https://doaj.org/article/9ef95dc3bce44f668e21a106a000cf31
Autor:
Camille Desgrouas, Alice-Anaïs Varlet, Anne Dutour, Damien Galant, Françoise Merono, Nathalie Bonello-Palot, Patrice Bourgeois, Adèle Lasbleiz, Cathy Petitjean, Patricia Ancel, Nicolas Levy, Catherine Badens, Bénédicte Gaborit
Publikováno v:
Cells, Vol 9, Iss 2, p 310 (2020)
This study details the clinical and cellular phenotypes associated with two missense heterozygous mutations in LMNA, c.1745G>T p.(Arg582Leu), and c.1892G>A p.(Gly631Asp), in two patients with early onset of diabetes mellitus, hypertriglyceridemia and
Externí odkaz:
https://doaj.org/article/b80c42a72b334a378e9c101f1dcf8c37
Autor:
Nicolas Levy, Aurélien Naldi, Céline Hernandez, Gautier Stoll, Denis Thieffry, Andrei Zinovyev, Laurence Calzone, Loïc Paulevé
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Boolean and multi-valued logical formalisms are increasingly used to model complex cellular networks. To ease the development and analysis of logical models, a series of software tools have been proposed, often with specific assets. However, combinin
Externí odkaz:
https://doaj.org/article/73d2481eef3c427ab3f0e5a1609afda5
Autor:
Aurélien Naldi, Céline Hernandez, Nicolas Levy, Gautier Stoll, Pedro T. Monteiro, Claudine Chaouiya, Tomáš Helikar, Andrei Zinovyev, Laurence Calzone, Sarah Cohen-Boulakia, Denis Thieffry, Loïc Paulevé
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Analysing models of biological networks typically relies on workflows in which different software tools with sensitive parameters are chained together, many times with additional manual steps. The accessibility and reproducibility of such workflows i
Externí odkaz:
https://doaj.org/article/9a2d4dac80934cea9cb3c36fd1316bdf