Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Nicolas, Le Novère"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1006991 (2020)
Calmodulin sits at the center of molecular mechanisms underlying learning and memory. Its complex and sometimes opposite influences, mediated via the binding to various proteins, are yet to be fully understood. Calcium/calmodulin-dependent protein ki
Externí odkaz:
https://doaj.org/article/21cc734feb2c417a81895733043ee415
Autor:
Manuel D. Díaz-Muñoz, Vladimir Yu. Kiselev, Nicolas Le Novère, Tomaz Curk, Jernej Ule, Martin Turner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independe
Externí odkaz:
https://doaj.org/article/be40aa23daf3428d9a9e7cfc26ff2f38
Autor:
Janna Hastings, Abraham Mains, Bhupinder Virk, Nicolas Rodriguez, Sharlene Murdoch, Juliette Pearce, Sven Bergmann, Nicolas Le Novère, Olivia Casanueva
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
In this contribution, we describe a multi-omics systems biology study of the metabolic changes that occur during aging in Caenorhabditis elegans. Sampling several time points from young adulthood until early old age, our study covers the full duratio
Externí odkaz:
https://doaj.org/article/9d7461fd6e8e4ba5b0f2aa04945fc1aa
Autor:
Natalie J Stanford, Katherine Wolstencroft, Martin Golebiewski, Renate Kania, Nick Juty, Christopher Tomlinson, Stuart Owen, Sarah Butcher, Henning Hermjakob, Nicolas Le Novère, Wolfgang Mueller, Jacky Snoep, Carole Goble
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 12, Pp 1-4 (2015)
Graphical Abstract A recent community survey conducted by Infrastructure for Systems Biology Europe (ISBE) informs requirements for developing an efficient infrastructure for systems biology standards, data and model management.
Externí odkaz:
https://doaj.org/article/5b02660082d9416cbf8da360e43f1f8a
Autor:
Michael Witting, Janna Hastings, Nicolas Rodriguez, Chintan J. Joshi, Jake P. N. Hattwell, Paul R. Ebert, Michel van Weeghel, Arwen W. Gao, Michael J. O. Wakelam, Riekelt H. Houtkooper, Abraham Mains, Nicolas Le Novère, Sean Sadykoff, Frank Schroeder, Nathan E. Lewis, Horst-Joachim Schirra, Christoph Kaleta, Olivia Casanueva
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Metabolism is one of the attributes of life and supplies energy and building blocks to organisms. Therefore, understanding metabolism is crucial for the understanding of complex biological phenomena. Despite having been in the focus of research for c
Externí odkaz:
https://doaj.org/article/ba4e5b226b894e14acb1ce2a596c70c2
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1005740 (2018)
Externí odkaz:
https://doaj.org/article/f04245210ce640299968d296cf15bbaa
Autor:
Julie A McMurry, Nick Juty, Niklas Blomberg, Tony Burdett, Tom Conlin, Nathalie Conte, Mélanie Courtot, John Deck, Michel Dumontier, Donal K Fellows, Alejandra Gonzalez-Beltran, Philipp Gormanns, Jeffrey Grethe, Janna Hastings, Jean-Karim Hériché, Henning Hermjakob, Jon C Ison, Rafael C Jimenez, Simon Jupp, John Kunze, Camille Laibe, Nicolas Le Novère, James Malone, Maria Jesus Martin, Johanna R McEntyre, Chris Morris, Juha Muilu, Wolfgang Müller, Philippe Rocca-Serra, Susanna-Assunta Sansone, Murat Sariyar, Jacky L Snoep, Stian Soiland-Reyes, Natalie J Stanford, Neil Swainston, Nicole Washington, Alan R Williams, Sarala M Wimalaratne, Lilly M Winfree, Katherine Wolstencroft, Carole Goble, Christopher J Mungall, Melissa A Haendel, Helen Parkinson
Publikováno v:
PLoS Biology, Vol 15, Iss 6, p e2001414 (2017)
In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on the humble bricks and mortar t
Externí odkaz:
https://doaj.org/article/2740a680c7c54ad590ec4fc17b1e468c
Autor:
Veronica Musante, Lu Li, Jean Kanyo, Tukiet T Lam, Christopher M Colangelo, Shuk Kei Cheng, A Harrison Brody, Paul Greengard, Nicolas Le Novère, Angus C Nairn
Publikováno v:
eLife, Vol 6 (2017)
ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A. ARPP-19 and ENSA phosphorylated by Greatwall kinase inhibit PP2A during mitosis. ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A
Externí odkaz:
https://doaj.org/article/1c6cbe02d5e743ca833ba86d9c17d590
Autor:
Ali Ebrahim, Eivind Almaas, Eugen Bauer, Aarash Bordbar, Anthony P Burgard, Roger L Chang, Andreas Dräger, Iman Famili, Adam M Feist, Ronan MT Fleming, Stephen S Fong, Vassily Hatzimanikatis, Markus J Herrgård, Allen Holder, Michael Hucka, Daniel Hyduke, Neema Jamshidi, Sang Yup Lee, Nicolas Le Novère, Joshua A Lerman, Nathan E Lewis, Ding Ma, Radhakrishnan Mahadevan, Costas Maranas, Harish Nagarajan, Ali Navid, Jens Nielsen, Lars K Nielsen, Juan Nogales, Alberto Noronha, Csaba Pal, Bernhard O Palsson, Jason A Papin, Kiran R Patil, Nathan D Price, Jennifer L Reed, Michael Saunders, Ryan S Senger, Nikolaus Sonnenschein, Yuekai Sun, Ines Thiele
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 10, Pp 1-3 (2015)
Graphical Abstract Recent results obtained by Chindelevitch et al (2014) are challenged by Ebrahim et al, illustrating several issues in the reproducibility of computational biology methods.
Externí odkaz:
https://doaj.org/article/889764d4207842bb8d486cb49f32b9c4
Autor:
Michel Dumontier, Alasdair J.G. Gray, M. Scott Marshall, Vladimir Alexiev, Peter Ansell, Gary Bader, Joachim Baran, Jerven T. Bolleman, Alison Callahan, José Cruz-Toledo, Pascale Gaudet, Erich A. Gombocz, Alejandra N. Gonzalez-Beltran, Paul Groth, Melissa Haendel, Maori Ito, Simon Jupp, Nick Juty, Toshiaki Katayama, Norio Kobayashi, Kalpana Krishnaswami, Camille Laibe, Nicolas Le Novère, Simon Lin, James Malone, Michael Miller, Christopher J. Mungall, Laurens Rietveld, Sarala M. Wimalaratne, Atsuko Yamaguchi
Publikováno v:
PeerJ, Vol 4, p e2331 (2016)
Access to consistent, high-quality metadata is critical to finding, understanding, and reusing scientific data. However, while there are many relevant vocabularies for the annotation of a dataset, none sufficiently captures all the necessary metadata
Externí odkaz:
https://doaj.org/article/87a6908c1991464f8c104ef7ffc724a9