Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Nicolas, Gisch"'
Autor:
Servane Payen, Marie-Christine Giroux, Nicolas Gisch, Ursula Schombel, Nahuel Fittipaldi, Mariela Segura, Marcelo Gottschalk
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-14 (2024)
Abstract Streptococcus suis serotype 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans, responsible for substantial economic losses to the swine industry worldwide. The pathogenesis of infection and the rol
Externí odkaz:
https://doaj.org/article/86a0d1e0177b4839925ee71488dee477
Autor:
Aranzazu Arias-Rojas, Adini Q Arifah, Georgia Angelidou, Belal Alshaar, Ursula Schombel, Emma Forest, Dagmar Frahm, Volker Brinkmann, Nicole Paczia, Chase L Beisel, Nicolas Gisch, Igor Iatsenko
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012462 (2024)
Multiple peptide resistance factor (MprF) confers resistance to cationic antimicrobial peptides (AMPs) in several pathogens, thereby enabling evasion of the host immune response. The role of MprF in commensals remains, however, uncharacterized. To cl
Externí odkaz:
https://doaj.org/article/0c6cb570cd50400c90092644d5058a49
Autor:
Michael Maybin, Aditi M. Ranade, Ursula Schombel, Nicolas Gisch, Uwe Mamat, Timothy C. Meredith
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Polymyxins [colistin and polymyxin B (PMB)] comprise an important class of natural product lipopeptide antibiotics used to treat multidrug-resistant Gram-negative bacterial infections. These positively charged lipopeptides interact with lipo
Externí odkaz:
https://doaj.org/article/93209f08620b44d7839200c2088766f4
Autor:
Andra B. Schromm, Wilmar Correa, Nicolas Gisch, Frank Steiniger, Walter Richter, Guillermo Martinez-de-Tejada, Klaus Brandenburg, Friedrich von Wintzingerode
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116286- (2024)
Lipopolysaccharide (LPS, endotoxin) is ubiquitous and represents a harmful contaminant of pharmaceutical compounds, recombinant biologicals and drug products. The pyrogen can induce severe immune responses and pathology in vitro and in vivo. Health a
Externí odkaz:
https://doaj.org/article/282bc62090fc41dc82babf4dfc3c3e6c
Autor:
Björn Klabunde, André Wesener, Wilhelm Bertrams, Isabell Beinborn, Nicole Paczia, Kristin Surmann, Sascha Blankenburg, Jochen Wilhelm, Javier Serrania, Kèvin Knoops, Eslam M. Elsayed, Katrin Laakmann, Anna Lena Jung, Andreas Kirschbaum, Sven Hammerschmidt, Belal Alshaar, Nicolas Gisch, Mobarak Abu Mraheil, Anke Becker, Uwe Völker, Evelyn Vollmeister, Birke J. Benedikter, Bernd Schmeck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Lower respiratory tract infections caused by Streptococcus pneumoniae (Spn) are a leading cause of death globally. Here we investigate the bronchial epithelial cellular response to Spn infection on a transcriptomic, proteomic and metabolic l
Externí odkaz:
https://doaj.org/article/f53e17d7ffee4a8b866fd16db80c5bb8
Autor:
Max Brendel, Thomas P. Kohler, Janine V. Neufend, Astrid Puppe, Nicolas Gisch, Sven Hammerschmidt
Publikováno v:
Journal of Innate Immunity, Pp 1-1 (2024)
Introduction: The hydrophilic, polymeric chain of the lipoteichoic acid (LTA) of the Gram-positive pathobiont Streptococcus pneumoniae is covalently linked to the glycosylglycerolipid α-d-glucopyranosyl-(1,3)-diacylglycerol by the LTA ligase TacL, l
Externí odkaz:
https://doaj.org/article/c5dedc7fe60c4d86a88960bed12a9f79
Autor:
Swapnil Prakash Doijad, Nicolas Gisch, Renate Frantz, Bajarang Vasant Kumbhar, Jane Falgenhauer, Can Imirzalioglu, Linda Falgenhauer, Alexander Mischnik, Jan Rupp, Michael Behnke, Michael Buhl, Simone Eisenbeis, Petra Gastmeier, Hanna Gölz, Georg Alexander Häcker, Nadja Käding, Winfried V. Kern, Axel Kola, Evelyn Kramme, Silke Peter, Anna M. Rohde, Harald Seifert, Evelina Tacconelli, Maria J. G. T. Vehreschild, Sarah V. Walker, Janine Zweigner, Dominik Schwudke, DZIF R-Net Study Group, Trinad Chakraborty
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Taxonomical complexity has muddled the classification of clinically relevant Enterobacter species. Authors carry out a genome-based study on clinical isolates to investigate colistin resistance and heteroresistance in Enterobacter.
Externí odkaz:
https://doaj.org/article/8f1968e0788d4d10b57c9ebfdab99a01
Autor:
Jonas Maurice Holzinger, Martina Toelge, Maren Werner, Katharina Ursula Ederer, Heiko Ingo Siegmund, David Peterhoff, Stefan Helmut Blaas, Nicolas Gisch, Christoph Brochhausen, André Gessner, Sigrid Bülow
Publikováno v:
eLife, Vol 12 (2023)
Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous antibiotic treatment. In this context, Pseudomonas aeruginosa (Pa) is of special concern since colonizing strains frequently acquire multiple drug resistance (M
Externí odkaz:
https://doaj.org/article/e18e2a0f9d3049ba86f727b237137350
Autor:
Renate Frantz, Konrad Gwozdzinski, Nicolas Gisch, Swapnil Prakash Doijad, Martina Hudel, Maria Wille, Mobarak Abu Mraheil, Dominik Schwudke, Can Imirzalioglu, Linda Falgenhauer, Michael Ehrmann, Trinad Chakraborty
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT The envelope stress response (ESR) of Gram-negative enteric bacteria senses fluctuations in nutrient availability and environmental changes to avert damage and promote survival. It has a protective role toward antimicrobials, but direct inte
Externí odkaz:
https://doaj.org/article/2d2db4a596354834aa96a8c1a3bfb711
Autor:
Vikrant Minhas, Arnau Domenech, Dimitra Synefiaridou, Daniel Straume, Max Brendel, Gonzalo Cebrero, Xue Liu, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Camilo Perez, Nicolas Gisch, Sven Hammerschmidt, Leiv Sigve Håvarstein, Jan-Willem Veening
Publikováno v:
PLoS Biology, Vol 21, Iss 1, p e3001990 (2023)
Competence development in the human pathogen Streptococcus pneumoniae controls several features such as genetic transformation, biofilm formation, and virulence. Competent bacteria produce so-called "fratricins" such as CbpD that kill noncompetent si
Externí odkaz:
https://doaj.org/article/252cf92d09a445cc86e9ebc4ccde10e5