Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Nicolas, Degauque"'
Autor:
Nicolas Sailliet, Amandine Dupuy, François Brinas, Karine Renaudin, Luc Colas, Clarisse Kerleau, Thi-Van-Ha Nguyen, Cynthia Fourgeux, Jérémie Poschmann, Clément Gosset, Magali Giral, Nicolas Degauque, Hoa Le Mai, Richard Danger, Sophie Brouard
Publikováno v:
Cells, Vol 13, Iss 15, p 1287 (2024)
The aim of our study was to determine whether granzyme B-expressing regulatory B cells (GZMB+ B cells) are enriched in the blood of transplant patients with renal graft tolerance. To achieve this goal, we analysed two single-cell RNA sequencing (scRN
Externí odkaz:
https://doaj.org/article/aa73797a72844d32a155d0443f3fbd31
Autor:
Nicolas Sailliet, Hoa-Le Mai, Amandine Dupuy, Gaëlle Tilly, Cynthia Fourgeux, Martin Braud, Magali Giral, Jean-Michel Robert, Nicolas Degauque, Richard Danger, Jeremie Poschmann, Sophie Brouard
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHuman Granzyme B (GZMB) regulatory B cells (Bregs) have suppressive properties on CD4+ effector T cells by a mechanism partially dependent on GZMB. Moreover, these cells may be easily induced in vitro making them interesting for cell ther
Externí odkaz:
https://doaj.org/article/fd8ac4765aaa4e34853bc71dad38a34f
Autor:
Emilie Gaiffe, Mathilde Colladant, Maxime Desmaret, Jamal Bamoulid, Franck Leroux, Caroline Laheurte, Sophie Brouard, Magali Giral, Philippe Saas, Cécile Courivaud, Nicolas Degauque, Didier Ducloux
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAcute rejection persists as a frequent complication after kidney transplantation. Defining an at-risk immune profile would allow better preventive approaches.MethodsWe performed unsupervised hierarchical clustering analysis on pre-transplan
Externí odkaz:
https://doaj.org/article/bdca9c74a59a40a18e275ca7606818cb
Autor:
Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anaïs Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe human immune system contains cells with either effector/memory or regulatory functions. Besides the well-established CD4+CD25hiCD127lo regulatory T cells (Tregs), we and others have shown that B cells can also have regulatory function
Externí odkaz:
https://doaj.org/article/c88d9c9bbb964e658df20ca7a76e4bae
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Activation of CD4 T cells by B cells has been extensively studied, but B cell-regulated priming, proliferation, and survival of CD8 T cells remains controversial. B cells express high levels of MHC class I molecules and can potentially act as antigen
Externí odkaz:
https://doaj.org/article/d84b0462efb544e3979d3808cb64a020
Autor:
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anaïs Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104226- (2022)
Summary: Background: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation such as aging, chronic viral infections, autoimmune diseases, cance
Externí odkaz:
https://doaj.org/article/58d1684669a64d518878509727335a7f
Autor:
Benjamin Gaborit, Bernard Vanhove, Marie-Anne Vibet, Aurélie Le Thuaut, Karine Lacombe, Vincent Dubee, Florence Ader, Virginie Ferre, Eric Vicaut, Jéremie Orain, Morgane Le Bras, Anne Omnes, Laetitia Berly, Alexandra Jobert, Pascale Morineau-Le Houssine, Karine Botturi, Régis Josien, Laurent Flet, Nicolas Degauque, Sophie Brouard, Odile Duvaux, Alexandra Poinas, François Raffi, POLYCOR study group
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background Early inhibition of entry and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising therapeutic approach. Polyclonal neutralizing antibodies offers many advantages such as providing im
Externí odkaz:
https://doaj.org/article/c0680748f60346049915c615da5ecaca
Autor:
Gaëlle Tilly, Marion Cadoux, Alexandra Garcia, Jérémy Morille, Sandrine Wiertlewski, Claire Pecqueur, Sophie Brouard, David Laplaud, Nicolas Degauque
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Background and ObjectivesInhibition of de novo pyrimidine synthesis in proliferating T and B lymphocytes by teriflunomide, a pharmacological inhibitor of dihydroorotate dehydrogenase (DHODH), has been shown to be an effective therapy to treat patient
Externí odkaz:
https://doaj.org/article/a07d9ea562304e78906881830d7bc40a
Autor:
Lyssia Belarif, Caroline Mary, Lola Jacquemont, Hoa Le Mai, Richard Danger, Jeremy Hervouet, David Minault, Virginie Thepenier, Veronique Nerrière-Daguin, Elisabeth Nguyen, Sabrina Pengam, Eric Largy, Arnaud Delobel, Bernard Martinet, Stéphanie Le Bas-Bernardet, Sophie Brouard, Jean-Paul Soulillou, Nicolas Degauque, Gilles Blancho, Bernard Vanhove, Nicolas Poirier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can re
Externí odkaz:
https://doaj.org/article/2f8d89dcfb614001945d31eee5d1a5ce
Autor:
Tra-My Doan Ngoc, Gaëlle Tilly, Richard Danger, Orianne Bonizec, Christophe Masset, Pierrick Guérif, Sarah Bruneau, Alexandre Glemain, Jean Harb, Marion Cadoux, Anaïs Vivet, Hoa Le Mai, Alexandra Garcia, David Laplaud, Roland Liblau, Magali Giral, Stéphanie Blandin, Magalie Feyeux, Laurence Dubreuil, Claire Pecqueur, Matthew Cyr, Weiming Ni, Sophie Brouard, Nicolas Degauque
Publikováno v:
Journal of the American Society of Nephrology. 33:2211-2231
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe1b9272842f389e5064fdd3f20a4076
https://doi.org/10.1681/asn.2022030286
https://doi.org/10.1681/asn.2022030286