A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization

Autor: Nicolas De Leiris, Pascale Perret, Charlotte Lombardi, Bülent Gözel, Sabine Chierici, Philippe Millet, Marlène Debiossat, Sandrine Bacot, Benjamin B. Tournier, Patrick Chames, Jean-Luc Lenormand, Catherine Ghezzi, Daniel Fagret, Marcelle Moulin

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)

Abstract Background Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation of Tau pathology in Alzheimer’s disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 as a novel radiotra

Externí odkaz: https://doaj.org/article/1ac0048706c44dee9da004630017f449

TrisOxine abiotic siderophores for technetium complexation: radiolabeling and biodistribution studies

Autor: Julien Leenhardt, Alexandre Biguet Petit Jean, Florian Raes, Emilien N’Guessan, Marlène Debiossat, Clémence André, Sandrine Bacot, Mitra Ahmadi, Nicolas de Leiris, Loïc Djaileb, Catherine Ghezzi, Marie-Dominique Brunet, Alexis Broisat, Pascale Perret, Amaury du Moulinet d’Hardemare

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-19 (2023)

Abstract Background Despite the development of positron emission tomography (PET), single photon emission computed tomography (SPECT) still accounts for around 80% of all examinations performed in nuclear medicine departments. The search for new radi

Externí odkaz: https://doaj.org/article/29b0c4ea072a4535bc2ebf12e6dba619

Does whole-body bone SPECT/CT provide additional diagnostic information over [18F]-FCH PET/CT for the detection of bone metastases in the setting of prostate cancer biochemical recurrence?

Autor: Nicolas de Leiris, Julien Leenhardt, Bastien Boussat, Christopher Montemagno, Alexandre Seiller, Olivier Phan Sy, Julie Roux, Mathieu Laramas, Camille Verry, Carole Iriart, Gaelle Fiard, Jean-Alexandre Long, Jean-Luc Descotes, Jean-Philippe Vuillez, Laurent Riou, Loïc Djaileb

Publikováno v: Cancer Imaging, Vol 20, Iss 1, Pp 1-11 (2020)

Abstract Background To assess whether whole-body (WB) bone SPECT/CT provides additional diagnostic information over [18F]-FCH PET/CT for the detection of bone metastases in the setting of prostate cancer biochemical recurrence (PC-BR). Methods Patien

Externí odkaz: https://doaj.org/article/3761ac253fc54aca8ee38bae1ce5bee7

Outcome Prediction at Patient Level Derived from Pre-Treatment 18F-FDG PET Due to Machine Learning in Metastatic Melanoma Treated with Anti-PD1 Treatment

Autor: Anthime Flaus, Vincent Habouzit, Nicolas de Leiris, Jean-Philippe Vuillez, Marie-Thérèse Leccia, Mathilde Simonson, Jean-Luc Perrot, Florent Cachin, Nathalie Prevot

Publikováno v: Diagnostics, Vol 12, Iss 2, p 388 (2022)

(1) Background: As outcome of patients with metastatic melanoma treated with anti-PD1 immunotherapy can vary in success, predictors are needed. We aimed to predict at the patients’ levels, overall survival (OS) and progression-free survival (PFS) a

Externí odkaz: https://doaj.org/article/ebae8b5c3e1c4ae9a87d72c5d8a3aa27

Multicellular tumor spheroids of LNCaP-Luc prostate cancer cells as in vitro screening models for cytotoxic drugs

Autor: Anthime Flaus, Vincent Habouzit, Nicolas de Leiris, Jean-Philippe Vuillez, Marie-Thérèse Leccia, Mathilde Simonson, Jean-Luc Perrot, Florent Cachin, Nathalie Prevot

Publikováno v: American Journal of Cancer Research
American Journal of Cancer Research, 2022, 12 (3), pp.1116-1128. ⟨10.3390/diagnostics12020388⟩
Diagnostics
Diagnostics, MDPI, 2022, 12 (2), pp.388. ⟨10.3390/diagnostics12020388⟩
American Journal of Cancer Research, e-Century Publishing, 2022, 12 (3), pp.1116-1128. ⟨10.3390/diagnostics12020388⟩
Diagnostics; Volume 12; Issue 2; Pages: 388

International audience; An increasing number of studies concerning solid cancers, including prostate cancer, are tending to demonstrate the predominant role of the interactions of tumor cells with their microenvironment, and underlining the relevance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da55e27547f0a152934851e54fea0029
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