Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables

Autor: Pablo Delgado-Wicke, Sara Fernández de Córdoba-Oñate, Emilia Roy-Vallejo, Estíbaliz Alegría-Carrasco, Diego A. Rodríguez-Serrano, Amalia Lamana, Nuria Montes, Ana Nicolao-Gómez, Rosa Carracedo-Rodríguez, Ana Marcos-Jiménez, Paula Díaz-Fernández, José M. Galván-Román, Laura Rabes-Rodríguez, Marta Sanz-Alba, Jesús Álvarez-Rodríguez, Almudena Villa-Martí, Carlos Rodríguez-Franco, Gonzalo Villapalos-García, Pablo Zubiaur, Francisco Abad-Santos, Ignacio de los Santos, Rosa P. Gomariz, Rosario García-Vicuña, Cecilia Muñoz-Calleja, Isidoro González-Álvaro, Elena Fernández-Ruiz, PREDINMUN-COVID Group

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract The characteristics of the host are crucial in the final outcome of COVID-19. Herein, the influence of genetic and clinical variants in COVID-19 severity was investigated in a total of 1350 patients. Twenty-one single nucleotide polymorphism

Externí odkaz: https://doaj.org/article/0d1fc16c70a649cfaebb526fed6a8fbd

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Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables.

Autor: Delgado-Wicke P; Molecular Biology Unit, Hospital Universitario La Princesa and Health Research Institute (IIS-Princesa), Madrid, Spain., Fernández de Córdoba-Oñate S; Rheumathology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain.; Hematology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Roy-Vallejo E; Internal Medicine Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Alegría-Carrasco E; Molecular Biology Unit, Hospital Universitario La Princesa and Health Research Institute (IIS-Princesa), Madrid, Spain., Rodríguez-Serrano DA; Intensive Care Unit, Hospital Universitario La Princesa (IIS Princesa), Madrid, Spain., Lamana A; Cell Biology Department, Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain., Montes N; Rheumathology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain.; Pharmaceutical and Health Sciences Department, Faculty of Pharmacy, Universidad San Pablo-CEU, Boadilla del Monte, Spain.; Methodology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Nicolao-Gómez A; Molecular Biology Unit, Hospital Universitario La Princesa and Health Research Institute (IIS-Princesa), Madrid, Spain., Carracedo-Rodríguez R; Molecular Biology Unit, Hospital Universitario La Princesa and Health Research Institute (IIS-Princesa), Madrid, Spain., Marcos-Jiménez A; Immunology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Díaz-Fernández P; Immunology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Galván-Román JM; Internal Medicine Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Rabes-Rodríguez L; Internal Medicine Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Sanz-Alba M; Internal Medicine Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Álvarez-Rodríguez J; Internal Medicine Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Villa-Martí A; Internal Medicine Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Rodríguez-Franco C; Internal Medicine Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain., Villapalos-García G; Clinical Pharmacology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain.; Pharmacology Department, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Zubiaur P; Clinical Pharmacology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain.; Pharmacology Department, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Abad-Santos F; Clinical Pharmacology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain.; Pharmacology Department, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., de Los Santos I; Internal Medicine Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Gomariz RP; Cell Biology Department, Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain., García-Vicuña R; Rheumathology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain.; Medicine Department, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Muñoz-Calleja C; Immunology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain.; Medicine Department, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., González-Álvaro I; Rheumathology Department, Hospital Universitario La Princesa (IIS-Princesa), Madrid, Spain. isidoro.ga@ser.es., Fernández-Ruiz E; Molecular Biology Unit, Hospital Universitario La Princesa and Health Research Institute (IIS-Princesa), Madrid, Spain. efruiz@salud.madrid.org.; Medicine Department, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain. efruiz@salud.madrid.org.

Publikováno v: Scientific reports [Sci Rep] 2024 Sep 05; Vol. 14 (1), pp. 20728. Date of Electronic Publication: 2024 Sep 05.

Degradation Rate Control Issues of PEO-Coated Wrought Mg0.5Zn0.2Ca Alloy.

Autor: Moreno, Lara, Mohedano, Marta, Arrabal, Raul, Matykina, Endzhe

Publikováno v: Coatings (2079-6412); Mar2024, Vol. 14 Issue 3, p309, 20p