Výsledky vyhledávání - "Nicolaj Rasmussen"

Data from Phage Display–Derived Human Monoclonal Antibodies Isolated by Binding to the Surface of Live Primary Breast Cancer Cells Recognize GRP78

Autor: Henrik J. Ditzel, Anne-Vibeke Laenkholm, Nicolaj Rasmussen, Charlotte G. Jakobsen

Clinical trials using monoclonal antibodies (mAb) against cell-surface markers have yielded encouraging therapeutic results in several cancer types. Generally, however, anticancer antibodies are only efficient against a subpopulation of cancers, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126c0b29c573a2017032012483feeb73
https://doi.org/10.1158/0008-5472.c.6495503

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Cross-species reactive monoclonal antibodies against the extracellular domains of the insulin receptor and IGF1 receptor

Autor: Morten Grønbech Rasch, Niels Blume, Laura Kofoed Hvidsten Ørstrup, Gerd Schluckebier, Henning Hvid, Bo Falck Hansen, Rita Slaaby, Søren Lund, Anne Lützen, Nicolaj Rasmussen, Thomas Åskov Pedersen, Zhe Wang, Jakob Brandt

Publikováno v: Ørstrup, L H, Slaaby, R, Rasch, M G, Rasmussen, N, Lund, S, Brandt, J, Schluckebier, G, Wang, Z, Lützen, A, Pedersen, T Å, Hvid, H, Hansen, B F & Blume, N 2019, ' Cross-species reactive monoclonal antibodies against the extracellular domains of the insulin receptor and IGF1 receptor ', Journal of Immunological Methods, vol. 465, pp. 20-26 . https://doi.org/10.1016/j.jim.2018.11.014

Translation across species of immunoassay results is often challenging due to the lack of cross-species reactivity of antibodies. In order to investigate the biology of insulin and IGF1 receptors, we generated new versatile monoclonal assay antibodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08c57a55c78ba4fa8c12343f49c4b28
https://pubmed.ncbi.nlm.nih.gov/30500329

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Phage Display–Derived Human Monoclonal Antibodies Isolated by Binding to the Surface of Live Primary Breast Cancer Cells Recognize GRP78

Autor: Anne Vibeke Lænkholm, Nicolaj Rasmussen, Henrik J. Ditzel, Charlotte G. Jakobsen

Publikováno v: Jakobsen, C G, Rasmussen, N, Laenkholm, A-V & Ditzel, H 2007, ' Phage display derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78 ', Cancer Research, vol. 67, no. 19, pp. 9507-17 . https://doi.org/10.1158/0008-5472.CAN-06-4686

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676444a25321a2f0fd26b60da6cdca5c
https://doi.org/10.1158/0008-5472.can-06-4686

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Effect of free fatty acids and lysolipids on cellular uptake of doxorubicin in human breast cancer cell lines

Autor: Henrik Jespersen, Henrik J. Ditzel, Nicolaj Rasmussen, Jonas H. Andersen, Ole G. Mouritsen

Publikováno v: Rasmussen, N, Andersen, J, Jespersen, H, Mouritsen, O G & Ditzel, H J 2010, ' Effect of free fatty acids and lysolipids on cellular uptake of doxorubicin in human breast cancer cell lines ', Anti-Cancer Drugs, vol. 21, no. 7, pp. 674-7 . https://doi.org/10.1097/CAD.0b013e32833c2cf7

Several fatty acids and lysolipids have been shown earlier to increase the permeability of membranes of artificial liposomes, thereby increasing the release of drugs such as doxorubicin (Dox) contained within them. Free fatty acids can also inhibit c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf80e749dd562b5fa8197fcebf6d079
https://pubmed.ncbi.nlm.nih.gov/20559126

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Scanning the cell surface proteome of cancer cells and identification of metastasis-associated proteins using a subtractive immunization strategy

Autor: Nicolaj Rasmussen, Henrik J. Ditzel

Publikováno v: Rasmussen, N & Ditzel, H J 2009, ' Scanning the cell surface proteome of cancer cells and identification of metastasis-associated proteins using a subtractive immunization strategy ', Journal of Proteome Research, vol. 8, no. 11, pp. 5048-5059 . https://doi.org/10.1021/pr9004635

Identification of the cell surface proteome and comparison of their expression between cells with different phenotypic characteristics is crucial to the discovery of novel cancer drug targets as well as elucidating the basic biologic processes of can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d87d809a4aca97137139d9641ef847c
https://pubmed.ncbi.nlm.nih.gov/19764822

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Identification of the specificity of isolated phage display single-chain antibodies using yeast two-hybrid screens

Autor: Nicolaj, Rasmussen, Henrik J, Ditzel

Publikováno v: Methods in molecular biology (Clifton, N.J.). 562

A method is described for the identification of the antigen recognised by an scFv isolated from an antibody phage display library using selection against a complex mixture of proteins (e.g. intact cells, purified cell surface membranes, and tissue se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::745cd9688ba076180b30380872d878fd
https://pubmed.ncbi.nlm.nih.gov/19554295

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