Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity

Autor: Matthew D. Lycas, Aske L. Ejdrup, Andreas T. Sørensen, Nicolai O. Haahr, Søren H. Jørgensen, Daryl A. Guthrie, Jonatan F. Støier, Christian Werner, Amy Hauck Newman, Markus Sauer, Freja Herborg, Ulrik Gether

Publikováno v: Lycas, M D, Ejdrup, A L, Sørensen, A T, Haahr, N O, Jørgensen, S H, Guthrie, D A, Støier, J F, Werner, C, Newman, A H, Sauer, M, Herborg, F & Gether, U 2022, ' Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity ', Cell Reports, vol. 40, no. 13, 111431 . https://doi.org/10.1016/j.celrep.2022.111431

The nanoscopic organization and regulation of individual molecular components in presynaptic varicosities of neurons releasing modulatory volume neurotransmitters like dopamine (DA) remain largely elusive. Here we show, by application of several supe

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https://doi.org/10.1016/j.celrep.2022.111431