Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Nicolai M. Doliba"'
Autor:
M. Grazia Cotticelli, Shujuan Xia, Rachel Truitt, Nicolai M. Doliba, Andrea V. Rozo, John W. Tobias, Taehee Lee, Justin Chen, Jill S. Napierala, Marek Napierala, Wenli Yang, Robert B. Wilson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/04295511604a417f96a22b6e45f7fbc4
Autor:
Xi Yan, Zeping Zhao, Jeremy Weaver, Tao Sun, Jun-Won Yun, Carol A. Roneker, Fenghua Hu, Nicolai M. Doliba, Charles Chipley W. McCormick, Marko Z. Vatamaniuk, Xin Gen Lei
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102457- (2022)
We previously reported a depletion of murine regenerating islet-derived protein 2 (REG2) in pancreatic islets of glutathione peroxidase-1 (Gpx1) overexpressing (OE) mice. The present study was to explore if and how the REG2 depletion contributed to a
Externí odkaz:
https://doaj.org/article/1ffca74d012b42eda88129d7fa11e263
Autor:
Nicolai M. Doliba, Andrea V. Rozo, Jeffrey Roman, Wei Qin, Daniel Traum, Long Gao, Jinping Liu, Elisabetta Manduchi, Chengyang Liu, Maria L. Golson, Golnaz Vahedi, Ali Naji, Franz M. Matschinsky, Mark A. Atkinson, Alvin C. Powers, Marcela Brissova, Klaus H. Kaestner, Doris A. Stoffers, for the HPAP Consortium
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
BACKGROUND Multiple islet autoantibodies (AAbs) predict the development of type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only approximately 15% of individuals who are positive for single AAbs (generally against
Externí odkaz:
https://doaj.org/article/ed4642c42951458c9cba96f40f54dcec
Autor:
Liu Liu, Diptadip Dattaroy, Katherine F. Simpson, Luiz F. Barella, Yinghong Cui, Yan Xiong, Jian Jin, Gabriele M. König, Evi Kostenis, Jefferey C. Roman, Klaus H. Kaestner, Nicolai M. Doliba, Jürgen Wess
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Glucagon, a hormone released from pancreatic α cells, plays a key role in maintaining euglycemia. New insights into the signaling pathways that control glucagon secretion may stimulate the development of novel therapeutic agents. In this study, we i
Externí odkaz:
https://doaj.org/article/c38dd95266e54296ab7d20f538d7f6e4
Publikováno v:
Molecular Metabolism, Vol 26, Iss , Pp 45-56 (2019)
Objective: Pancreatic β cell failure plays a central role in the development of type 2 diabetes (T2D). While the transcription factors shaping the β cell gene expression program have received much attention, the post-transcriptional controls that a
Externí odkaz:
https://doaj.org/article/92feb68a50ff450dbea3acb1c59b44a1
Autor:
Austin L. Good, Corey E. Cannon, Matthew W. Haemmerle, Juxiang Yang, Diana E. Stanescu, Nicolai M. Doliba, Morris J. Birnbaum, Doris A. Stoffers
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 95-106 (2019)
Objective: In type 2 diabetes (T2D), oxidative stress contributes to the dysfunction and loss of pancreatic β cells. A highly conserved feature of the cellular response to stress is the regulation of mRNA translation; however, the genes regulated at
Externí odkaz:
https://doaj.org/article/49f72e95647f4aa0be1c4d9996d87bb3
Autor:
Nicolai M. Doliba, Qin Liu, Changhong Li, Pan Chen, Chengyang Liu, Ali Naji, Franz M. Matschinsky
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1240-1253 (2017)
Objectives: Chronic hyperlipidemia and hyperglycemia are characteristic features of type 2 diabetes (T2DM) that are thought to cause or contribute to β-cell dysfunction by “glucolipotoxicity.” Previously we have shown that acute treatment of pan
Externí odkaz:
https://doaj.org/article/32855ad926304bd38f411ad1b808bf91
Autor:
Awo Akosua Kesewa Layman, Guoping Deng, Claire E. O’Leary, Samuel Tadros, Rajan M. Thomas, Joseph M. Dybas, Emily K. Moser, Andrew D. Wells, Nicolai M. Doliba, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Tregcell IL-4 production and metab
Externí odkaz:
https://doaj.org/article/89da5cb9551e485e8433cc421115f741
Autor:
Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron, David A. Jacobson, Alejandro Caicedo, Jürgen Wess
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in b
Externí odkaz:
https://doaj.org/article/66d5119437c34bdaa2ffe7d281b224eb
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. The changes in myocardial structure and function associated with diabetes are collectively called diabetic cardiomyopathy. Numerous molecular mechanisms
Externí odkaz:
https://doaj.org/article/1a8a9fca245846c6b391fcbe74324ce6