Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Nicolai M Doliba"'
Autor:
Regan Roat, Vandana Rao, Nicolai M Doliba, Franz M Matschinsky, John W Tobias, Eden Garcia, Rexford S Ahima, Yumi Imai
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86815 (2014)
The reduction of functional β cell mass is a key feature of type 2 diabetes. Here, we studied metabolic functions and islet gene expression profiles of C57BL/6J mice with naturally occurring nicotinamide nucleotide transhydrogenase (NNT) deletion mu
Externí odkaz:
https://doaj.org/article/ff5d65fed52c4d5e9b430969e7092d39
Autor:
M. Grazia Cotticelli, Shujuan Xia, Rachel Truitt, Nicolai M. Doliba, Andrea V. Rozo, John W. Tobias, Taehee Lee, Justin Chen, Jill S. Napierala, Marek Napierala, Wenli Yang, Robert B. Wilson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/04295511604a417f96a22b6e45f7fbc4
Autor:
Xi Yan, Zeping Zhao, Jeremy Weaver, Tao Sun, Jun-Won Yun, Carol A. Roneker, Fenghua Hu, Nicolai M. Doliba, Charles Chipley W. McCormick, Marko Z. Vatamaniuk, Xin Gen Lei
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102457- (2022)
We previously reported a depletion of murine regenerating islet-derived protein 2 (REG2) in pancreatic islets of glutathione peroxidase-1 (Gpx1) overexpressing (OE) mice. The present study was to explore if and how the REG2 depletion contributed to a
Externí odkaz:
https://doaj.org/article/1ffca74d012b42eda88129d7fa11e263
Autor:
Nicolai M. Doliba, Andrea V. Rozo, Jeffrey Roman, Wei Qin, Daniel Traum, Long Gao, Jinping Liu, Elisabetta Manduchi, Chengyang Liu, Maria L. Golson, Golnaz Vahedi, Ali Naji, Franz M. Matschinsky, Mark A. Atkinson, Alvin C. Powers, Marcela Brissova, Klaus H. Kaestner, Doris A. Stoffers, for the HPAP Consortium
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
BACKGROUND Multiple islet autoantibodies (AAbs) predict the development of type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only approximately 15% of individuals who are positive for single AAbs (generally against
Externí odkaz:
https://doaj.org/article/ed4642c42951458c9cba96f40f54dcec
Autor:
Liu Liu, Diptadip Dattaroy, Katherine F. Simpson, Luiz F. Barella, Yinghong Cui, Yan Xiong, Jian Jin, Gabriele M. König, Evi Kostenis, Jefferey C. Roman, Klaus H. Kaestner, Nicolai M. Doliba, Jürgen Wess
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Glucagon, a hormone released from pancreatic α cells, plays a key role in maintaining euglycemia. New insights into the signaling pathways that control glucagon secretion may stimulate the development of novel therapeutic agents. In this study, we i
Externí odkaz:
https://doaj.org/article/c38dd95266e54296ab7d20f538d7f6e4
Autor:
Awo Akosua Kesewa Layman, Guoping Deng, Claire E. O’Leary, Samuel Tadros, Rajan M. Thomas, Joseph M. Dybas, Emily K. Moser, Andrew D. Wells, Nicolai M. Doliba, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Tregcell IL-4 production and metab
Externí odkaz:
https://doaj.org/article/89da5cb9551e485e8433cc421115f741
Autor:
Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron, David A. Jacobson, Alejandro Caicedo, Jürgen Wess
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in b
Externí odkaz:
https://doaj.org/article/66d5119437c34bdaa2ffe7d281b224eb
Autor:
M. Grazia Cotticelli, Shujuan Xia, Rachel Truitt, Nicolai M. Doliba, Andrea V. Rozo, John W. Tobias, Taehee Lee, Justin Chen, Jill S. Napierala, Marek Napierala, Wenli Yang, Robert B. Wilson
Publikováno v:
Disease Models & Mechanisms. 16
Friedreich ataxia, the most common hereditary ataxia, is a neuro- and cardio-degenerative disorder caused, in most cases, by decreased expression of the mitochondrial protein frataxin. Cardiomyopathy is the leading cause of premature death. Frataxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280e386c3405185c942d85764a3b1d2f
https://doi.org/10.1242/dmm.049497
https://doi.org/10.1242/dmm.049497
Autor:
NICOLAI M. DOLIBA, JEFFREY ROMAN, ANDREA V. ROZO, WEI QIN, CHENGYANG LIU, ALI NAJI, MICHAEL R. RICKELS, MARK A. ATKINSON, ALVIN C. POWERS, MARCELA BRISSOVA, KLAUS H. KAESTNER, DORIS A. STOFFERS
Publikováno v:
Diabetes. 71
Purpose: We tested the hypothesis that a critical biologic determinant of T2D disparities is based on ethnicity-related differences in pancreatic islet function. Methods: Utilizing donor tissues from the NIDDK-funded Human Pancreas Analysis Program (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f525d290adb079b821baff3ce9f49ee1
https://doi.org/10.2337/db22-253-lb
https://doi.org/10.2337/db22-253-lb
Autor:
JONATHAN W. SNYDER, SARAH K. MONTGOMERY, NICOLAI M. DOLIBA, JEFFREY ROMAN, YUZHEN TIAN, PRISCILA Y. SATO, WILLIAM L. HOLLAND, RAN HEE CHOI
Publikováno v:
Diabetes. 71
Insulin deficiency is central to diabetes and diabetes-related cardiac dysfunction. GPCRs are known modulators of insulin secretion and a main pharmacological target in various tissues, including the heart. GPCR kinase 2 (GRK2) phosphorylates activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff6af7e2d794ed8162442c09363f0332
https://doi.org/10.2337/db22-252-lb
https://doi.org/10.2337/db22-252-lb