Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicolai K. Andersen"'
Autor:
Christopher P. Lawson, Anders F. Füchtbauer, Moa S. Wranne, Tristan Giraud, Thomas Floyd, Blaise Dumat, Nicolai K. Andersen, Afaf H. El-Sagheer, Tom Brown, Henrik Gradén, L. Marcus Wilhelmsson, Morten Grøtli
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Fluorescent base analogues (FBAs) have emerged as a powerful class of molecular reporters of location and environment for nucleic acids. In our overall mission to develop bright and useful FBAs for all natural nucleobases, herein we describe
Externí odkaz:
https://doaj.org/article/91467726e61f4f76abb1785ce4f6f727
Autor:
Patrick J. Hrdlicka, Tomasz Krzywkowski, Jesper Wengel, Mats Nilsson, Chenguang Lou, Per T. Jørgensen, Karin E. Lundin, Sylvain Geny, Rula Zain, Abdirisaq J. Isse, Pedro Moreno, Nicolai K. Andersen, Amro M. El-Madani, Eman M. Zaghloul, Y. Vladimir Pabon, Erik B. Pedersen, Brooke A. Anderson, C. I. Edvard Smith, Olof Gissberg
Publikováno v:
Geny, S, Moreno, P M D, Krzywkowski, T, Gissberg, O, Andersen, N K, Isse, A J, El-Madani, A M, Lou, C, Pabon, Y V, Anderson, B A, Zaghloul, E M, Zain, R, Hrdlicka, P J, Jørgensen, P T, Nilsson, M, Lundin, K E, Pedersen, E B, Wengel, J & Smith, C I E 2016, ' Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes ', Nucleic Acids Research, vol. 44, no. 5, pp. 2007-2019 . https://doi.org/10.1093/nar/gkw021
Nucleic Acids Research
Nucleic Acids Research
Targeting and invading double-stranded DNA with synthetic oligonucleotides under physiological conditions remain a challenge. Bis-locked nucleic acids (bisLNAs) are clamp-forming oligonucleotides able to invade into supercoiled DNA via combined Hoogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a02dd63cd74049655d3b2a48a35844
https://findresearcher.sdu.dk:8443/ws/files/119274236/Nucl._Acids_Res._2016_Geny_2007_19.pdf
https://findresearcher.sdu.dk:8443/ws/files/119274236/Nucl._Acids_Res._2016_Geny_2007_19.pdf
Autor:
Lucie Brulíková, Nicolai K. Andersen, Pawan K. Sharma, Pawan Kumar, Michael Dalager Jensen, Poul Nielsen, Navneet Chandak, Frank Jensen
Publikováno v:
Andersen, N K, Chandak, N, Brulikova, L, Kumar, P, Jensen, M D, Jensen, F, Sharma, P K & Poul, N 2010, ' Efficient RNA-targeting by the Introduction of Aromatic Stacking in the Duplex Major Groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2'-deoxyuridines ', Bioorganic & Medicinal Chemistry, vol. 18, pp. 4702-4710 .
Aarhus University
Aarhus University
Three pyrimidine nucleosides with differently substituted phenyltriazoles attached to the 5-position were prepared by Cu(I)-assisted azide-alkyne cycloadditions (CuAAC) and incorporated into oligonucleotides. Efficient π-π-stacking between two or m
Publikováno v:
Jensen, M D, Andersen, N K, Kumar, P, Nielsen, P & Sharma, P K 2015, ' Double-headed nucleotides introducing thymine nucleobases in the major groove of nucleic acid duplexes ', Organic & Biomolecular Chemistry, vol. 13, pp. 7040-7049 . https://doi.org/10.1039/C5OB00872G
Four different double-headed nucleosides each combining two thymine nucleobases with different linkers were synthesised. The 5-position of 2′-deoxyuridine was connected to the N1-position of a thymine through either m- or p-disubstituted phenyl or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9420c299c53b3c6edef02fccf735be00
https://findresearcher.sdu.dk:8443/ws/files/120470678/c5ob00872g.pdf
https://findresearcher.sdu.dk:8443/ws/files/120470678/c5ob00872g.pdf
Autor:
Jesper Wengel, Flemming Gundorph Hansen, Jan Stenvang Jepsen, Claus J. Nielsen, Nicolai K. Andersen, Patrick J. Hrdlicka, Kim F. Haselmann
Publikováno v:
Hrdlicka, P J, Andersen, N K, Jepsen, J S, Hansen, F G, Haselmann, K, Nielsen, C & Wengel, J 2005, ' Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd) ', Bioorganic & Medicinal Chemistry, vol. 13, no. 7, pp. 2597-2621 . https://doi.org/10.1016/j.bmc.2005.01.029
The synthesis of branched and conformationally restricted analogs of the anticancer nucleosides 3′-C-ethynyluridine (EUrd) and 3′-C-ethynylcytidine (ECyd) is presented. Molecular modeling and 1H NMR coupling constant analysis revealed that the fu
Publikováno v:
ChemInform. 45
The development of conformationally restricted nucleotide building blocks continues to attract considerable interest because of their successful use within antisense, antigene, and other gene-targeting strategies. Locked nucleic acid (LNA) and its di
Autor:
Gerald Enderlin, Pawan Kumar, Gwénaëlle Hervé, Poul Nielsen, Nicolai K. Andersen, Christophe Len, Lise Junker Nielsen, Mick Hornum, Guillaume Sartori
Publikováno v:
Kumar, P, Hornum, M, Nielsen, L J, Enderlin, G, Andersen, N K, Len, C, Hervé, G, Sartori, G & Nielsen, P 2014, ' High affinity RNA targeting by oligonucleotides displaying aromatic stacking and amino groups in the major groove. Comparison of triazoles and phenylsubstituents ', Journal of Organic Chemistry, vol. 79, no. 7, pp. 2854-2863 . https://doi.org/10.1021/jo4025896
Three 5-modified 2'-deoxyuridine nucleosides were synthesized and incorporated into oligonucleotides and compared with the previously published 5-(1-phenyl-1,2,3-triazol-4-yl)-2'-deoxyuridine monomer W. The introduction of an aminomethyl group on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031ed8cd70ca8496c4a37fb66e7869a5
https://portal.findresearcher.sdu.dk/da/publications/374f59cc-1f24-4d0a-ae59-e926b88bfde3
https://portal.findresearcher.sdu.dk/da/publications/374f59cc-1f24-4d0a-ae59-e926b88bfde3
Autor:
Patrick J. Hrdlicka, Saswata Karmakar, Rie L. Rathje, Peter Podbevšek, Pawan Kumar, Dale C. Guenther, Nicolai K. Andersen, T. Santhosh Kumar, Sanne Andersen, Brooke A. Anderson, Sujay P. Sau, Andreas Stahl Madsen, Janez Plavec, Jesper Wengel
Publikováno v:
Sau, S P, Madsen, A S, Podbevsek, P, Andersen, N K, Kumar, T S, Andersen, S, Rathje, R L, Anderson, B A, Guenther, D C, Karmakar, S, Kumar, P, Plavec, J, Wengel, J & Hrdlicka, P J 2013, ' Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA ', Journal of Organic Chemistry, vol. 78, no. 19, pp. 9560-9570 . https://doi.org/10.1021/jo4015936
The development of synthetic agents that recognize double-stranded DNA (dsDNA) is a long-standing goal that is inspired by the promise for tools that detect, regulate, and modify genes. Progress has been made with triplex-forming oligonucleotides, pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff101e025ee6138205529f29ca3597c
https://portal.findresearcher.sdu.dk/da/publications/63446fd4-60fb-4249-a88a-342713b210eb
https://portal.findresearcher.sdu.dk/da/publications/63446fd4-60fb-4249-a88a-342713b210eb
Publikováno v:
Andersen, N K, Anderson, B A, Wengel, J & Hrdlicka, P J 2013, ' Synthesis and Characterization of Oligodeoxyribonucleotides Modified with 2'-Amino-α-l-LNA Adenine Monomers : High-Affinity Targeting of Single-Stranded DNA ', Journal of Organic Chemistry, vol. 78, no. 24, pp. 12690-12702 . https://doi.org/10.1021/jo4022937
The development of conformationally restricted nucleotide building blocks continues to attract considerable interest because of their successful use within antisense, antigene, and other gene-targeting strategies. Locked nucleic acid (LNA) and its di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e45a5c58d27da4fd07f64206279ae2
https://portal.findresearcher.sdu.dk/da/publications/6b9356f1-91b7-4269-89e1-e0e6aba4ff6f
https://portal.findresearcher.sdu.dk/da/publications/6b9356f1-91b7-4269-89e1-e0e6aba4ff6f
Publikováno v:
Andersen, N K, Døssing, H, Jensen, F, Vester, B & Nielsen, P 2011, ' Duplex and Triplex Formation of Mixed Pyrimidine Oligonucleotides with Stacking of Phenyl-triazole Moieties in the Major Groove ', Journal of Organic Chemistry, vol. 76, no. 15, pp. 6177-87 . https://doi.org/10.1021/jo200919y
Andersen, N K, Døssing, H B, Jensen, F, Vester, B & Nielsen, P 2011, ' Duplex and triplex formation of mixed pyrimidine oligonucleotides with stacking of phenyl-triazole moieties in the major groove ', Journal of Organic Chemistry, vol. 76, no. 15, pp. 6177-87 . https://doi.org/10.1021/jo200919y
Andersen, N K, Døssing, H B, Jensen, F, Vester, B & Nielsen, P 2011, ' Duplex and triplex formation of mixed pyrimidine oligonucleotides with stacking of phenyl-triazole moieties in the major groove ', Journal of Organic Chemistry, vol. 76, no. 15, pp. 6177-87 . https://doi.org/10.1021/jo200919y
5-(1-Phenyl-1,2,3-triazol-4-yl)-2′-deoxycytidine was synthesized from a modified CuAAC protocol and incorporated into mixed pyrimidine oligonucleotide sequences together with the corresponding 5-(1-phenyl-1,2,3-triazol-4-yl)-2′-deoxyuridine. With