Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Nicolai J. Wewer Albrechtsen"'
Autor:
Ulrikka Nygaard, Annelaura Bach Nielsen, Kia Hee Schultz Dungu, Lylia Drici, Mette Holm, Maud Eline Ottenheijm, Allan Bybeck Nielsen, Jonathan Peter Glenthøj, Lisbeth Samsø Schmidt, Dina Cortes, Inger Merete Jørgensen, Trine Hyrup Mogensen, Kjeld Schmiegelow, Matthias Mann, Nadja Hawwa Vissing, Nicolai J. Wewer Albrechtsen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Multisystem inflammatory syndrome in children (MIS-C) is a severe disease that emerged during the COVID-19 pandemic. Although recognized as an immune-mediated condition, the pathogenesis remains unresolved. Furthermore, the absence of a diag
Externí odkaz:
https://doaj.org/article/48a8c9538a9045699b5e329e6d316bf2
Autor:
Dorte B. Zilstorff, Michael M. Richter, Jens Hannibal, Henrik L. Jørgensen, Henriette P. Sennels, Nicolai J. Wewer Albrechtsen
Publikováno v:
BMC Endocrine Disorders, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Glucagon is secreted from pancreatic alpha cells in response to low blood glucose and increases hepatic glucose production. Furthermore, glucagon enhances hepatic protein and lipid metabolism during a mixed meal. Glucagon-like pep
Externí odkaz:
https://doaj.org/article/af7449196ed44efa95d41e34b1120f96
Autor:
Kasper J. Mygind, Denise Nikodemus, Sebastian Gnosa, Ramya Kweder, Nicolai J. Wewer Albrechtsen, Marie Kveiborg, Janine T. Erler, Reidar Albrechtsen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5871 (2024)
Desmoplasia is a common feature of aggressive cancers, driven by a complex interplay of protein production and degradation. Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface.
Externí odkaz:
https://doaj.org/article/825f5f9180ec45d2a84117c4c5f040ba
Autor:
Filip Mundt, Sebastian Porsdam Mann, Nicolai J. Wewer Albrechtsen, Medini Ghodgaonkar-Steger, Peter Treit, Reinout Raijmakers, Martina O’Flaherty, Albert J.R. Heck, Juan Antonio Vizcaíno, Matthias Mann
Publikováno v:
Open Research Europe, Vol 3 (2023)
With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research. More than 95% of FDA-approved dr
Externí odkaz:
https://doaj.org/article/c298c9b3eb4a4260a6f44bad67047e22
Autor:
Sasha A.S. Kjeldsen, Lise L. Gluud, Mikkel P. Werge, Julie S. Pedersen, Flemming Bendtsen, Kleopatra Alexiadou, Tricia Tan, Signe S. Torekov, Eva W. Iepsen, Nicole J. Jensen, Michael M. Richter, Jens P. Goetze, Jørgen Rungby, Bolette Hartmann, Jens J. Holst, Birgitte Holst, Joachim Holt, Finn Gustafsson, Sten Madsbad, Maria S. Svane, Kirstine N. Bojsen-Møller, Nicolai J. Wewer Albrechtsen
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108190- (2023)
Summary: Inhibitors of neprilysin improve glycemia in patients with heart failure and type 2 diabetes (T2D). The effect of weight loss by diet, surgery, or pharmacotherapy on neprilysin activity (NEPa) is unknown. We investigated circulating NEPa and
Externí odkaz:
https://doaj.org/article/541de04b6ddd4e19900f1ffa4e360c15
Autor:
Filip Mundt, Sebastian Porsdam Mann, Nicolai J. Wewer Albrechtsen, Medini Ghodgaonkar-Steger, Peter Treit, Reinout Raijmakers, Martina O’Flaherty, Albert J.R. Heck, Juan Antonio Vizcaíno, Matthias Mann
Publikováno v:
Open Research Europe, Vol 3 (2023)
With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research. More than 95% of FDA-approved dr
Externí odkaz:
https://doaj.org/article/414f3e7d31fd4a8d8506e4105d106b7a
Autor:
Josephine Grandt, Anne‐Sofie H. Jensen, Mikkel P. Werge, Elias B. Rashu, Andreas Møller, Anders E. Junker, Lise Hobolth, Christian Mortensen, Christian D. Johansen, Mogens Vyberg, Reza Rafiolsadat Serizawa, Søren Møller, Lise Lotte Gluud, Nicolai J. Wewer Albrechtsen
Publikováno v:
Physiological Reports, Vol 11, Iss 8, Pp n/a-n/a (2023)
Abstract Fatty liver disease has mainly been characterized under fasting conditions. However, as the liver is essential for postprandial homeostasis, identifying postprandial disturbances may be important. Here, we investigated postprandial changes i
Externí odkaz:
https://doaj.org/article/5b92858c4b1641adbc65716474f5fd74
Autor:
Hirofumi Nagao, Weikang Cai, Bruna B. Brandão, Nicolai J. Wewer Albrechtsen, Martin Steger, Arijeet K. Gattu, Hui Pan, Jonathan M. Dreyfuss, F. Thomas Wunderlich, Matthias Mann, C. Ronald Kahn
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here
Externí odkaz:
https://doaj.org/article/22ea319743b447ccb3e07487b07381ad
Autor:
Katrine D. Galsgaard, Emilie Elmelund, Christian D. Johansen, Anna B. Bomholt, Hüsün S. Kizilkaya, Frederik Ceutz, Jenna E. Hunt, Hannelouise Kissow, Marie Winther-Sørensen, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Mette M. Rosenkilde, Cathrine Ørskov, Christina Christoffersen, Jens J. Holst, Nicolai J. Wewer Albrechtsen
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101639- (2022)
Objective: Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice. Methods: Chronic
Externí odkaz:
https://doaj.org/article/a7ae536eaac7430393a76a080bee5d30
Autor:
Emilie Elmelund, Katrine D. Galsgaard, Christian D. Johansen, Samuel A.J. Trammell, Anna B. Bomholt, Marie Winther-Sørensen, Jenna E. Hunt, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Trisha J. Grevengoed, Jens J. Holst, Nicolai J. Wewer Albrechtsen
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105296- (2022)
Summary: The pancreatic hormone, glucagon, is known to regulate hepatic glucose production, but recent studies suggest that its regulation of hepatic amino metabolism is equally important. Here, we show that chronic glucagon receptor activation with
Externí odkaz:
https://doaj.org/article/300e9213de6c4cefb0c83693badfc6e2