Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nicolai J, Toft"'
Autor:
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-27 (2023)
Abstract Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal
Externí odkaz:
https://doaj.org/article/43eb9c61abb047289a64eb505c8ecf73
Autor:
Nicolai J Toft, Trine V Axelsen, Helene L Pedersen, Marco Mele, Mark Burton, Eva Balling, Tonje Johansen, Mads Thomassen, Peer M Christiansen, Ebbe Boedtkjer
Publikováno v:
eLife, Vol 10 (2021)
Breast cancer heterogeneity in histology and molecular subtype influences metabolic and proliferative activity and hence the acid load on cancer cells. We hypothesized that acid-base transporters and intracellular pH (pHi) dynamics contribute inter-i
Externí odkaz:
https://doaj.org/article/d654619d0e9a42edb5ad6ac158c69716
Autor:
Rasmus A. Sloth, Trine V. Axelsen, Maria Sofia Espejo, Nicolai J. Toft, Ninna C. S. Voss, Mark Burton, Mads Thomassen, Pernille Vahl, Ebbe Boedtkjer
Publikováno v:
Sloth, R A, Axelsen, T V, Espejo, M S, Toft, N J, Voss, N C S, Burton, M, Thomassen, M, Vahl, P & Boedtkjer, E 2022, ' Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival ', British Journal of Cancer, vol. 127, no. 7, pp. 1226-1238 . https://doi.org/10.1038/s41416-022-01911-6
Background: While cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and underlying molecular mechanisms responding to the tumour microenvironment remain unclear. Methods
Autor:
Mads Thomassen, Peer Christiansen, Trine V Axelsen, Ebbe Boedtkjer, Marco Mele, Helene L Pedersen, Tonje Johansen, Mark Burton, Eva Balling, Nicolai J Toft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe84be00a67f928d3ce2c04baa5fba9
https://doi.org/10.7554/elife.68447.sa2
https://doi.org/10.7554/elife.68447.sa2