Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Nicolai Franzmeier"'
Autor:
Johannes Gnörich, Mara Koehler, Karin Wind-Mark, Carolin Klaus, Artem Zatcepin, Giovanna Palumbo, Manvir Lalia, Laura Sebastian Monasor, Leonie Beyer, Florian Eckenweber, Maximilian Scheifele, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Henryk Barthel, Osama Sabri, Peter Bartenstein, Jochen Herms, Sabina Tahirovic, Nicolai Franzmeier, Sibylle Ziegler, Matthias Brendel
Publikováno v:
NeuroImage, Vol 297, Iss , Pp 120748- (2024)
Aim: β-amyloid (Aβ) small animal PET facilitates quantification of fibrillar amyloidosis in Alzheimer's disease (AD) mouse models. Thus, the methodology is receiving growing interest as a monitoring tool in preclinical drug trials. In this regard,
Externí odkaz:
https://doaj.org/article/c4e03c5007ba44899c8b242dbed9d9d7
Autor:
Nicolai Franzmeier, Amir Dehsarvi, Anna Steward, Davina Biel, Anna Dewenter, Sebastian Niclas Roemer, Fabian Wagner, Mattes Groß, Matthias Brendel, Alexis Moscoso, Prithvi Arunachalam, Kaj Blennow, Henrik Zetterberg, Michael Ewers, Michael Schöll
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract In Alzheimer’s disease, amyloid-beta (Aβ) triggers the trans-synaptic spread of tau pathology, and aberrant synaptic activity has been shown to promote tau spreading. Aβ induces aberrant synaptic activity, manifesting in increases in the
Externí odkaz:
https://doaj.org/article/805dd9e85c8145c99b2ccade83ebcf4a
Autor:
Gloria Biechele, Boris-Stephan Rauchmann, Daniel Janowitz, Katharina Buerger, Nicolai Franzmeier, Endy Weidinger, Selim Guersel, Sebastian Schuster, Anika Finze, Stefanie Harris, Simon Lindner, Nathalie L. Albert, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Carla Palleis, Sabrina Katzdobler, Lena Burow, Carolin Kurz, Mirlind Zaganjori, Lena-Katharina Trappmann, Oliver Goldhardt, Timo Grimmer, Jan Haeckert, Daniel Keeser, Sophia Stoecklein, Estrella Morenas-Rodriguez, Peter Bartenstein, Johannes Levin, Günter U. Höglinger, Mikael Simons, Robert Perneczky, Matthias Brendel
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background and objectives 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer’s disease (AD) research. Sex and obesity effects on TSPO-PET binding hav
Externí odkaz:
https://doaj.org/article/1204a7a1ca6b4f63bf9f3e18c9bf5978
Autor:
Davina Biel, Ying Luan, Matthias Brendel, Paul Hager, Anna Dewenter, Alexis Moscoso, Diana Otero Svaldi, Ixavier A. Higgins, Michael Pontecorvo, Sebastian Römer, Anna Steward, Anna Rubinski, Lukai Zheng, Michael Schöll, Sergey Shcherbinin, Michael Ewers, Nicolai Franzmeier, the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background Tau-PET is a prognostic marker for cognitive decline in Alzheimer’s disease, and the heterogeneity of tau-PET patterns matches cognitive symptom heterogeneity. Thus, tau-PET may allow precision-medicine prediction of individual
Externí odkaz:
https://doaj.org/article/ccfa8ae4ae3c45568c2230133b4c334b
Autor:
Alexa Pichet Binette, Nicolai Franzmeier, Nicola Spotorno, Michael Ewers, Matthias Brendel, Davina Biel, Alzheimer’s Disease Neuroimaging Initiative, Olof Strandberg, Shorena Janelidze, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Ruben Smith, Erik Stomrud, Rik Ossenkoppele, Oskar Hansson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The interplay between amyloid and tau pathology in Alzheimer’s disease is still not well understood. Here, the authors show that amyloid-related increased in soluble p-tau is related to subsequent accumulation of tau aggregates and cognitive declin
Externí odkaz:
https://doaj.org/article/d1cde27011a649659e040123199efd35
Autor:
Anna Rubinski, Nicolai Franzmeier, Anna Dewenter, Ying Luan, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Martin Dichgans, Oskar Hansson, Michael Ewers, the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background In Alzheimer’s disease (AD), fibrillar tau initially occurs locally and progresses preferentially between closely connected regions. However, the underlying sources of regional vulnerability to tau pathology remain unclear. Prev
Externí odkaz:
https://doaj.org/article/06f1a6bae9d74d0782c1d4ebcb60ec24
Autor:
Lukas Frontzkowski, Michael Ewers, Matthias Brendel, Davina Biel, Rik Ossenkoppele, Paul Hager, Anna Steward, Anna Dewenter, Sebastian Römer, Anna Rubinski, Katharina Buerger, Daniel Janowitz, Alexa Pichet Binette, Ruben Smith, Olof Strandberg, Niklas Mattsson Carlgren, Martin Dichgans, Oskar Hansson, Nicolai Franzmeier
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Individuals with young onset sporadic Alzheimer’s disease show faster pathological and clinical progression. Here the authors report that earlier symptom onset in Alzheimer’s disease is associated with higher tau pathology in globally connected b
Externí odkaz:
https://doaj.org/article/e1741019979b493fa3b111ba1f20853a
Autor:
Nicolai Franzmeier, Matthias Brendel, Leonie Beyer, Luna Slemann, Gabor G. Kovacs, Thomas Arzberger, Carolin Kurz, Gesine Respondek, Milica J. Lukic, Davina Biel, Anna Rubinski, Lukas Frontzkowski, Selina Hummel, Andre Müller, Anika Finze, Carla Palleis, Emanuel Joseph, Endy Weidinger, Sabrina Katzdobler, Mengmeng Song, Gloria Biechele, Maike Kern, Maximilian Scheifele, Boris-Stephan Rauchmann, Robert Perneczky, Michael Rullman, Marianne Patt, Andreas Schildan, Henryk Barthel, Osama Sabri, Jost J. Rumpf, Matthias L. Schroeter, Joseph Classen, Victor Villemagne, John Seibyl, Andrew W. Stephens, Edward B. Lee, David G. Coughlin, Armin Giese, Murray Grossman, Corey T. McMillan, Ellen Gelpi, Laura Molina-Porcel, Yaroslau Compta, John C. van Swieten, Laura Donker Laat, Claire Troakes, Safa Al-Sarraj, John L. Robinson, Sharon X. Xie, David J. Irwin, Sigrun Roeber, Jochen Herms, Mikael Simons, Peter Bartenstein, Virginia M. Lee, John Q. Trojanowski, Johannes Levin, Günter Höglinger, Michael Ewers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
Externí odkaz:
https://doaj.org/article/bd1a4c237aa0450eb6ad79b56669c4c6
Autor:
Davina Biel, Marc Suárez‐Calvet, Paul Hager, Anna Rubinski, Anna Dewenter, Anna Steward, Sebastian Roemer, Michael Ewers, Christian Haass, Matthias Brendel, Nicolai Franzmeier, the Alzheimer's Disease Neuroimaging Initiative (ADNI)
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Microglial activation occurs early in Alzheimer's disease (AD) and previous studies reported both detrimental and protective effects of microglia on AD progression. Here, we used CSF sTREM2 to investigate disease stage‐dependent drivers of
Externí odkaz:
https://doaj.org/article/ea66371c81c9496c92efbf79d69b23c9
Autor:
Mirthe Coenen, Geert Jan Biessels, Charles DeCarli, Evan F. Fletcher, Pauline M. Maillard, Frederik Barkhof, Josephine Barnes, Thomas Benke, Jooske M.F. Boomsma, Christopher P.L.H. Chen, Peter Dal-Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G. Exalto, Nicolai Franzmeier, Onno Groeneveld, Saima Hilal, Edith Hofer, Huiberdina L. Koek, Andrea B. Maier, Cheryl R. McCreary, Janne M. Papma, Ross W. Paterson, Yolande A.L. Pijnenburg, Anna Rubinski, Reinhold Schmidt, Jonathan M. Schott, Catherine F. Slattery, Eric E. Smith, Carole H. Sudre, Rebecca M.E. Steketee, Esther van den Berg, Wiesje M. van der Flier, Narayanaswamy Venketasubramanian, Meike W. Vernooij, Frank J. Wolters, Xu Xin, J. Matthijs Biesbroek, Hugo J. Kuijf
Publikováno v:
NeuroImage: Clinical, Vol 40, Iss , Pp 103547- (2023)
Introduction: The spatial distribution of white matter hyperintensities (WMH) on MRI is often considered in the diagnostic evaluation of patients with cognitive problems. In some patients, clinicians may classify WMH patterns as “unusual”, but th
Externí odkaz:
https://doaj.org/article/5540ab7b51b04a4e98f8f59244635cc5