Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nicolai Birkbak"'
Autor:
Huiqiang Cai, Bin Zhang, Johanne Ahrenfeldt, Justin V. Joseph, Maria Riedel, Zongliang Gao, Sofie K. Thomsen, Ditte S. Christensen, Rasmus O. Bak, Henrik Hager, Mikkel H. Vendelbo, Xin Gao, Nicolai Birkbak, Martin K. Thomsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Metastatic prostate cancer (PCa) poses a significant therapeutic challenge with high mortality rates. Utilizing CRISPR-Cas9 in vivo, we target five potential tumor suppressor genes (Pten, Trp53, Rb1, Stk11, and RnaseL) in the mouse prostate,
Externí odkaz:
https://doaj.org/article/b26426d9b48c4a0dba41510dd87eb43f
Autor:
Yin Wu, Charles Swanton, Mihaela Angelova, Crispin Hiley, Marleen Kok, Nicolai Birkbak, Ieva Usaite, Dhruva Biswas, Krijn Dijkstra, Thomas BK Watkins, Oriol Pich, Clare Puttick, Krupa Thakkar, Simone Zaccaria, Kevin Litchfield, Nnennaya Kanu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Checkpoint inhibitor (CPI) immunotherapies have provided durable clinical responses across a range of solid tumor types for some patients with cancer. Nonetheless, response rates to CPI vary greatly between cancer types. Resolving intratum
Externí odkaz:
https://doaj.org/article/da17de2de8c74189b560015ef1154a8e
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/3501aaab35b54b22b228bf781aeafa88
Autor:
Trine Strandgaard, Sia Viborg Lindskrog, Iver Nordentoft, Emil Christensen, Karin Birkenkamp-Demtröder, Tine Ginnerup Andreasen, Philippe Lamy, Asbjørn Kjær, Daniel Ranti, Yuanshuo Alice Wang, Christine Bieber, Frederik Prip, Julie Rasmussen, Torben Steiniche, Nicolai Birkbak, John Sfakianos, Amir Horowitz, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
Publikováno v:
Strandgaard, T, Lindskrog, S V, Nordentoft, I, Christensen, E, Birkenkamp-Demtröder, K, Andreasen, T G, Lamy, P, Kjær, A, Ranti, D, Wang, Y A, Bieber, C, Prip, F, Rasmussen, J, Steiniche, T, Birkbak, N, Sfakianos, J, Horowitz, A, Jensen, J B & Dyrskjøt, L 2022, ' Elevated T-cell Exhaustion and Urinary Tumor DNA Levels Are Associated with Bacillus Calmette-Guérin Failure in Patients with Non-muscle-invasive Bladder Cancer ', European Urology, vol. 82, no. 6, pp. 646-656 . https://doi.org/10.1016/j.eururo.2022.09.008
BACKGROUND: The functional status of immune cells in the tumor microenvironment and tumor characteristics may explain bacillus Calmette-Guérin (BCG) failure in high-risk non-muscle-invasive bladder cancer (NMIBC).OBJECTIVE: To characterize molecular
The application of next-generation sequencing (NGS) has transformed cancer research. As costs have decreased, NGS has increasingly been applied to generate multiple layers of molecular data from the same samples, covering genomics, transcriptomics, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc2643c300f0d66c54e869dc871e49f
https://doi.org/10.7554/elife.87133.1
https://doi.org/10.7554/elife.87133.1
Autor:
Trine Strandgaard, Sia Viborg Lindskrog, Iver Nordentoft, Emil Christensen, Karin Birkenkamp-Demtröder, Tine Ginnerup Andreasen, Philippe Lamy, Asbjørn Kjær, Daniel Ranti, Yuan-Sho Wang, Christine Bieber, Frederik Prip, Julie Rasmussen, Torben Steiniche, Nicolai Birkbak, John Sfakianos, Amir Horowitz, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
BackgroundThe functional status of immune cells within the tumor microenvironment and tumor characteristics may explain Bacillus Calmette-Guérin (BCG)-failure in high-risk non-muscle invasive bladder cancer (NMIBC).ObjectiveTo characterize molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::592a544509144ab0a41256f1d9c32b3f
https://doi.org/10.1101/2022.03.23.22272806
https://doi.org/10.1101/2022.03.23.22272806
Publikováno v:
Cancer Research. 82:924-924
Prostate cancer (PCa) is a most common cause of cancer-related death in men. While it develops to metastatic stage, the treatment options are limited. Hence, it desires in vivo models to test novel strategies for treating PCa. Current murine models o
Autor:
Javier Herrero, Gary Middleton, John Edwards, Richard Kevin Stone, Dominic Rothwell, Fiona Blackhall, Lynsey Priest, Marco Scarci, Caroline Dive, Mickael Escudero, Babu Naidu, Christian Ottensmeier, Michael Shackcloth, Kevin Litchfield, Nicolai Birkbak, Istvan Csabai, Neal Navani, Helen Lowe, JAMES READING, Paulo De Sousa, Francesca Chemi, Nicholas McGranahan, Diana Johnson, Hugo Aerts, John Le Quesne, Benny Chain, Stuart Horswell, Robert Hynds
Publikováno v:
López, S, Lim, E L, Horswell, S, Haase, K, Huebner, A, Dietzen, M, Mourikis, T P, Watkins, T B K, Rowan, A, Dewhurst, S M, Birkbak, N J, Wilson, G A, Van Loo, P, Jamal-Hanjani, M, TRACERx Consortium, Swanton, C & McGranahan, N 2020, ' Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution ', Nature Genetics, vol. 52, no. 3, pp. 283-293 . https://doi.org/10.1038/s41588-020-0584-7
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD in cancer have not been inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1ee9a4e42587bf9c5abc0eac1af53b
https://pure.au.dk/portal/da/publications/interplay-between-wholegenome-doubling-and-the-accumulation-of-deleterious-alterations-in-cancer-evolution(3dc8435d-beb5-4dc1-bc25-aef984b4cdb0).html
https://pure.au.dk/portal/da/publications/interplay-between-wholegenome-doubling-and-the-accumulation-of-deleterious-alterations-in-cancer-evolution(3dc8435d-beb5-4dc1-bc25-aef984b4cdb0).html
Autor:
Javier Herrero, Gary Middleton, Phil Crosbie, Charles Swanton, John Edwards, Peter Van Loo, Richard Kevin Stone, Sam Janes, Dominic Rothwell, Andrew Feber, Sergio Quezada, Fiona Blackhall, Henrik Walter, Lynsey Priest, Marco Scarci, Caroline Dive, Mickael Escudero, Babu Naidu, Christian Ottensmeier, Marcin Skrzypski, Eric Lim, Jonas Demeulemeester, Siow Ming Lee, Joanne Louise Laycock, Michael Shackcloth, Assma Ben Aissa, Nicolai Birkbak, Zoltan Szallasi, Neal Navani, Helen Lowe, Elizabeth Larose Cadieux, JAMES READING, Paulo De Sousa, Francesca Chemi, Nicholas McGranahan, Diana Johnson, Marafioti Teresa, Hugo Aerts, John Le Quesne, Benny Chain, Miljana Tanic, Robert Hynds, Sridhar Rathinam
The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and histopathology-assessed tumour-infiltratin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ea10339dcfb1fe8d615c58995dfb31
https://europepmc.org/articles/PMC6954100/
https://europepmc.org/articles/PMC6954100/