Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nicolai B, Larsen"'
Autor:
Zita Fábián, Ellen S. Kakulidis, Ivo A. Hendriks, Ulrike Kühbacher, Nicolai B. Larsen, Marta Oliva-Santiago, Junhui Wang, Xueyuan Leng, A. Barbara Dirac-Svejstrup, Jesper Q. Svejstrup, Michael L. Nielsen, Keith Caldecott, Julien P. Duxin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also inv
Externí odkaz:
https://doaj.org/article/427734112e584ecc9b9b66e9b3111faa
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2113-2125.e6 (2019)
Summary: Progression of DNA replication depends on the ability of the replisome complex to overcome nucleoprotein barriers. During eukaryotic replication, the CMG helicase translocates along the leading-strand template and unwinds the DNA double heli
Externí odkaz:
https://doaj.org/article/f6b26536f1594403a318945154e5691d
Autor:
Sascha, Krakovka, Farahnaz, Ranjbarian, Lucas A, Luján, Alicia, Saura, Nicolai B, Larsen, Alejandro, Jiménez-González, Anna, Reggenti, Hugo D, Luján, Staffan G, Svärd, Anders, Hofer
Publikováno v:
The Journal of biological chemistry. 298(6)
Giardiasis is a diarrheal disease caused by the unicellular parasite Giardia intestinalis, for which metronidazole is the main treatment option. The parasite is dependent on exogenous deoxyribonucleosides for DNA replication and thus is also potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a566d6307b17ffea5b07b45bd56663d2
https://pubmed.ncbi.nlm.nih.gov/35568200
https://pubmed.ncbi.nlm.nih.gov/35568200
Autor:
Sascha Emilie Liberti, Nicolai B. Larsen, Michael Lisby, Ian D. Hickson, Signe W. Jørgensen, Hocine W. Mankouri
Publikováno v:
Jørgensen, S W, Liberti, S E, Larsen, N B, Lisby, M, Mankouri, H W & Hickson, I D 2019, ' Esc2 promotes telomere stability in response to DNA replication stress ', Nucleic Acids Research, vol. 47, no. 9, pp. 4597-4611 . https://doi.org/10.1093/nar/gkz158
Nucleic Acids Research
Nucleic Acids Research
Telomeric regions of the genome are inherently difficult-to-replicate due to their propensity to generate DNA secondary structures and form nucleoprotein complexes that can impede DNA replication fork progression. Precisely how cells respond to DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3c566f2c5899fb3f774d5770afcfa8
https://doi.org/10.1093/nar/gkz158
https://doi.org/10.1093/nar/gkz158
Autor:
Ulrike Kühbacher, Irene Gallina, Julio C Y Liu, Yoshiaki Azuma, Nicolai B. Larsen, Claire Guérillon, Nikoline Borgermann, Niels Mailand, Ronald T. Hay, Emma Branigan, Leena Ackermann, Dimitriya H Garvanska, Ivo A. Hendriks, Michael L. Nielsen, Peter Haahr, Julien P. Duxin
Publikováno v:
Liu, J C Y, Kühbacher, U, Larsen, N B, Borgermann, N, Garvanska, D H, Hendriks, I A, Ackermann, L, Haahr, P, Gallina, I, Guérillon, C, Branigan, E, Hay, R T, Azuma, Y, Nielsen, M L, Duxin, J P & Mailand, N 2021, ' Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway ', E M B O Journal, vol. 40, e107413 . https://doi.org/10.15252/embj.2020107413
The EMBO Journal
The EMBO Journal
DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fd624e33a326d63e7e57078ba37ff6
https://curis.ku.dk/ws/files/280729418/embj.2020107413.pdf
https://curis.ku.dk/ws/files/280729418/embj.2020107413.pdf
Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts
Autor:
Alan O. Gao, Irene Gallina, Matthias Mann, Julien P. Duxin, Johannes C. Walter, R. Alex Wu, Justin L. Sparks, Markus Räschle, Nicolai B. Larsen
Publikováno v:
Molecular Cell
Larsen, N B, Gao, A O, Sparks, J L, Gallina, I, Wu, R A, Mann, M, Räschle, M, Walter, J C & Duxin, J P 2019, ' Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts ', Molecular Cell, vol. 73, no. 3, pp. 574-588.e7 . https://doi.org/10.1016/j.molcel.2018.11.024
Larsen, N B, Gao, A O, Sparks, J L, Gallina, I, Wu, R A, Mann, M, Räschle, M, Walter, J C & Duxin, J P 2019, ' Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts ', Molecular Cell, vol. 73, no. 3, pp. 574-588.e7 . https://doi.org/10.1016/j.molcel.2018.11.024
Summary DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S phase removal of DPCs, but how SPRTN is targeted to DPCs duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34489c5b76b8ec7d6e55c6f3eedd380a
Autor:
Simon Rasmussen, Selene Sellés-Baiget, Alan O. Gao, Joachim Johansen, Irene Gallina, Ivo A. Hendriks, Saskia Hoffmann, Michael L. Nielsen, Markus Räschle, Lisa Schubert, Nicolai B. Larsen, Ulrike Kühbacher, Zita Fábián, Niels Mailand, Julien P. Duxin, Camilla S. Colding-Christensen
Publikováno v:
Molecular Cell
Gallina, I, Hendriks, I A, Hoffmann, S, Larsen, N B, Johansen, J, Colding-Christensen, C S, Schubert, L, Sellés-Baiget, S, Fábián, Z, Kühbacher, U, Gao, A O, Räschle, M, Rasmussen, S, Nielsen, M L, Mailand, N & Duxin, J P 2021, ' The ubiquitin ligase RFWD3 is required for translesion DNA synthesis ', Molecular Cell, vol. 81, no. 3, pp. 442-458.e9 . https://doi.org/10.1016/j.molcel.2020.11.029
Gallina, I, Hendriks, I A, Hoffmann, S, Larsen, N B, Johansen, J, Colding-Christensen, C S, Schubert, L, Sellés-Baiget, S, Fábián, Z, Kühbacher, U, Gao, A O, Räschle, M, Rasmussen, S, Nielsen, M L, Mailand, N & Duxin, J P 2021, ' The ubiquitin ligase RFWD3 is required for translesion DNA synthesis ', Molecular Cell, vol. 81, no. 3, pp. 442-458.e9 . https://doi.org/10.1016/j.molcel.2020.11.029
Summary Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication. Gap-filling synthesis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5628841756ceff13bb1b14a50d115a27
https://doi.org/10.1016/j.molcel.2020.11.029
https://doi.org/10.1016/j.molcel.2020.11.029
Autor:
Johannes C. Walter, Alan O. Gao, Matthias Mann, Irene Gallina, Nicolai B. Larsen, Julien P. Duxin, Justin L. Sparks, Markus Räschle
SummaryDNA-protein crosslinks (DPCs) are bulky DNA lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S-phase removal of DPCs, but how SPRTN activity is coupled t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca618c8fd1b2b80c684aa261e8abc558
Autor:
Alan O. Gao, Markus Räschle, Nicolai B. Larsen, Johannes C. Walter, Justin L. Sparks, Julien P. Duxin, Matthias Mann
SummaryCovalent and non-covalent nucleoprotein complexes impede replication fork progression and thereby threaten genome integrity. UsingXenopus laevisegg extracts, we previously showed that when a replication fork encounters a covalent DNA-protein c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed4cdbcb41f1c745d4130bb118045d2
Autor:
Justin L. Sparks, Alan O. Gao, Johannes C. Walter, Markus Räschle, Gheorghe Chistol, Julien P. Duxin, Matthias Mann, Nicolai B. Larsen
Publikováno v:
Cell
Sparks, J L, Chistol, G, Gao, A O, Räschle, M, Larsen, N B, Mann, M, Duxin, J P & Walter, J C 2019, ' The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair ', Cell, vol. 176, no. 1-2, pp. 167-181.e21 . https://doi.org/10.1016/j.cell.2018.10.053
Sparks, J L, Chistol, G, Gao, A O, Räschle, M, Larsen, N B, Mann, M, Duxin, J P & Walter, J C 2019, ' The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair ', Cell, vol. 176, no. 1-2, pp. 167-181.e21 . https://doi.org/10.1016/j.cell.2018.10.053
Summary Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten genome integrity. Using Xenopus egg extracts, we previously showed that replication fork collision with DPCs causes their proteolysis, followed by transl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e05115f0c5bd036cf446bd2a8de930
https://pubmed.ncbi.nlm.nih.gov/30595447
https://pubmed.ncbi.nlm.nih.gov/30595447