Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging

Autor: Fusheng Yang, Sean Nazari, Edmond Teng, Fatiha Nothias, Sally A. Frautschy, Ping-Ping Chen, Mher Alaverdyan, Qiu-Lan Ma, Dana J. Gant, Piu Chan, Nicolae C. Kiosea, Xiaohong Zuo, Greg M. Cole, Oliver J. Ubeda

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2014, 34 (21), pp.7124-7136. ⟨10.1523/JNEUROSCI.3439-13.2014⟩
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 34, iss 21
Journal of Neuroscience, 2014, 34 (21), pp.7124-7136. ⟨10.1523/JNEUROSCI.3439-13.2014⟩

International audience; Hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including Alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c54091330cde3ba0267e191c987a5c
https://hal.archives-ouvertes.fr/hal-01542860