Cutaneous Mitochondrial P o 2, but Not Tissue Oxygen Saturation, Is an Early Indicator of the Physiologic Limit of Hemodilution in the Pig

Autor: Charlotte L. Bakker, Luuk H. L. Römers, Nathalie Dollee, Sanne E. Hoeks, Nicolaas J.H. Raat, Robert Jan Stolker, Alexandre Lima, Tanja Johannes, Egbert G. Mik

Publikováno v: Anesthesiology, 125(1), 124-132. Lippincott Williams & Wilkins

Background Hemodilution is a consequence of fluid replacement during blood loss and is limited by the individual ability to compensate for decreasing hemoglobin level. We tested the ability of a novel noninvasive method for measuring cutaneous mitoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d104143384d4ce00df3d7a4865f498f
http://www.scopus.com/inward/record.url?scp=84967017621&partnerID=8YFLogxK

Rejuvenation of stored human red blood cells reverses the renal microvascular oxygenation deficit in an isovolemic transfusion model in rats

Autor: Dirk de Korte, Arthur J. Verhoeven, Nicolaas J.H. Raat, Can Ince, Tanja Johannes, P. M. Hilarius

Publikováno v: Transfusion, 49(3), 427-434. Wiley-Blackwell

BACKGROUND: Storage of red blood cells (RBCs) results in various biochemical changes, including a decrease in cellular adenosine triphosphate and 2,3-diphosphoglycerate acid. Previously it was shown that stored human RBCs show a deficit in the oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06369e09d8cd3c671bacfdff3b8df10e
https://doi.org/10.1111/j.1537-2995.2008.02002.x

Effects of recombinant-hemoglobin solutions rHb2.0 and rHb1.1 on blood pressure, intestinal blood flow, and gut oxygenation in a rat model of hemorrhagic shock

Autor: Jing-Feng Liu, Jan Klein, Nicolaas J.H. Raat, Can Ince, Michael P. Doyle, Kenneth E. Burhop

Publikováno v: Journal of laboratory and clinical medicine, 145(1), 21-32. Mosby Inc.
Journal of Laboratory and Clinical Medicine, 145, 21-32. Mosby Inc.

The vasoconstriction induced by hemoglobin-based oxygen carriers (HBOCs), mainly a result of nitric oxide (NO) scavenging, until now has limited the application of HBOCs as resuscitation fluids. In this study, we tested the hypothesis that the new mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d284f6b0fa85d3cf8305783d0da8f4
https://doi.org/10.1016/j.lab.2004.05.017

Nitric Oxide Scavenging By Red Cell Microparticles And Cell Free Hemoglobin As A Mechanism For The Red Cell Storage Lesion

Autor: Chenell Donadee, Lirong Qu, Mark T. Gladwin, Janet S. Lee, Ernest M. Meyer, Nicolaas J.H. Raat, Xuejun Zhao, Hannah Reynolds, Albert D. Donnenberg, Jesús Tejero, Darrell J. Triulzi, Eric E. Kelley, Ivan Azarov, Daniel B. Kim-Shapiro, Chen Liu

Publikováno v: D35. OXIDANTS AND ANTIOXIDANTS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::524c2b32923fe8598d904b7261d85c40
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5955

Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response

Autor: Xiuli Xu, Peter J. Munson, Sruti Shiva, Delong Liu, Nalini Raghavachari, Virginia B. Liu, Audrey Noguchi, Mark T. Gladwin, Nicolaas J.H. Raat

Publikováno v: Free radical biologymedicine. 47(5)

Dietary nitrate, found in abundance in green vegetables, can be converted to the cytoprotective molecule nitrite by oral bacteria, suggesting that nitrate and nitrite may represent active cardioprotective constituents of the Mediterranean diet. We th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d979c8b2ab6f0feff50388dd285ac458
https://pubmed.ncbi.nlm.nih.gov/19464364