Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Nicolaas H. C. Brons"'
Autor:
Anne Dirkse, Anna Golebiewska, Thomas Buder, Petr V. Nazarov, Arnaud Muller, Suresh Poovathingal, Nicolaas H. C. Brons, Sonia Leite, Nicolas Sauvageot, Dzjemma Sarkisjan, Mathieu Seyfrid, Sabrina Fritah, Daniel Stieber, Alessandro Michelucci, Frank Hertel, Christel Herold-Mende, Francisco Azuaje, Alexander Skupin, Rolf Bjerkvig, Andreas Deutsch, Anja Voss-Böhme, Simone P. Niclou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by mo
Externí odkaz:
https://doaj.org/article/f9953d80d7214efbbab8832d2c810d81
Autor:
Tatiana Michel, Aurélie Poli, Olivia Domingues, Marion Mauffray, Maud Thérésine, Nicolaas H. C. Brons, François Hentges, Jacques Zimmer
Publikováno v:
PLoS ONE, Vol 8, Iss 1 (2013)
Externí odkaz:
https://doaj.org/article/6e9df81ce28243369ac7ca086228f348
Autor:
Sonia Leite, Christel Herold-Mende, Anna Dirkse, Dzjemma Sarkisjan, Daniel Stieber, Nicolaas H. C. Brons, Sabrina Fritah, Thomas Buder, Rolf Bjerkvig, Anja Voss-Böhme, Francisco Azuaje, Andreas Deutsch, Simone P. Niclou, Nicolas Sauvageot, Frank Hertel, Alesandro Michelucci, Mathieu Seyfrid, Petr V. Nazarov, Anna Golebiewska, Alexander Skupin, Suresh Poovathingal, Arnaud Muller
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Dirkse, A, Golebiewska, A, Buder, T, Nazarov, P V, Muller, A, Poovathingal, S, Brons, N H C, Leite, S, Sauvageot, N, Sarkisjan, D, Seyfrid, M, Fritah, S, Stieber, D, Michelucci, A, Hertel, F, Herold-Mende, C, Azuaje, F, Skupin, A, Bjerkvig, R, Deutsch, A, Voss-Böhme, A & Niclou, S P 2019, ' Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment ', Nature Communications, vol. 10, no. 1, 1787 . https://doi.org/10.1038/s41467-019-09853-z
Nature Communications, 10(1):1787. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Dirkse, A, Golebiewska, A, Buder, T, Nazarov, P V, Muller, A, Poovathingal, S, Brons, N H C, Leite, S, Sauvageot, N, Sarkisjan, D, Seyfrid, M, Fritah, S, Stieber, D, Michelucci, A, Hertel, F, Herold-Mende, C, Azuaje, F, Skupin, A, Bjerkvig, R, Deutsch, A, Voss-Böhme, A & Niclou, S P 2019, ' Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment ', Nature Communications, vol. 10, no. 1, 1787 . https://doi.org/10.1038/s41467-019-09853-z
Nature Communications, 10(1):1787. Nature Publishing Group
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma (GBM) do not represent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41916d135cd4cd09182249c39df34022
https://hdl.handle.net/1956/22507
https://hdl.handle.net/1956/22507
Autor:
Martha Chekenya, Andreas Waha, Jacques Zimmer, Per Øyvind Enger, Justyna Kmiecik, Aurélie Poli, Geir Egil Eide, Nicolaas H. C. Brons
Publikováno v:
Journal of Neuroimmunology
We characterized GBM patients' tumor and systemic immune contexture with aim to reveal themechanisms of immunological escape, their impact on patient outcome, and identify targets for immunotherapy. Increased CD3+ T-cell infiltration was associated w
Autor:
Sébastien Bougnaud, Nicolaas H. C. Brons, Evelin Schröck, Rolf Bjerkvig, Laurent Vallar, Anna Golebiewska, Simone P. Niclou, Barbara Klink, Daniel Stieber, Frank Hertel
Publikováno v:
Brain
The identification and significance of cancer stem-like cells in malignant gliomas remains controversial. It has been proposed that cancer stem-like cells display increased drug resistance, through the expression of ATP-binding cassette transporters
Interindividual variability and co-regulation of DNA methylation differ among blood cell populations
Publikováno v:
Epigenetics. 7:1421-1434
DNA methylation regulates gene expression in a cell-type specific way. Although peripheral blood mononuclear cells (PBMCs) comprise a heterogeneous cell population, most studies of DNA methylation in blood are performed on total mononuclear cells. In
Autor:
Graham A. Smith, David L. Allen, Elisabeth Schaffner-Reckinger, Michael F. Murphy, Willem H. Ouwehand, Nicolaas H. C. Brons, Nelly Kieffer, Graham J. Howkins, Paul Metcalfe, Nicholas A. Watkins
A single nucleotide polymorphism (SNP) at position 196 in the beta 3 integrin causes a Leu33Pro substitution in the mature protein. Alloimmunization against the beta 3Leu33 form (human platelet antigen [HPA]-1a, Pl(A1), Zw(a)) in patients who are bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4874998c321873ea2715e34c91cf8f
https://ora.ox.ac.uk/objects/uuid:f9c01aef-11d1-426e-9bb7-d2a9bf3ab36b
https://ora.ox.ac.uk/objects/uuid:f9c01aef-11d1-426e-9bb7-d2a9bf3ab36b
Autor:
Olivia Domingues, François Hentges, Jacques Zimmer, Wim Ammerlaan, Aurélie Poli, Maud Theresine, Nicolaas H. C. Brons, Tatiana Michel
Publikováno v:
The Journal of Immunology. 186:6497-6504
Neurotrophins such as nerve growth factor and brain-derived neurotrophic factor have been described to be involved in the pathogenesis of asthma. Neurturin (NTN), another neurotrophin from the glial cell line-derived neurotrophic factor family, was s
Autor:
Jesús Planagumà, Wouter R. van Furth, Jan Ingemann Heggdal, Joost J.C. Verhoeff, Per Øystein Sakariassen, Justyna Kmiecik, Agnete Svendsen, Inger Anne Netland, Martha Chekenya, Lars Prestegarden, Anneli Bohne Kjersem, Aurélie Poli, Rolf Bjerkvig, Andreas Waha, Morten Lund-Johansen, Nicolaas H. C. Brons, Karl Johan Tronstad, Per Øyvind Enger, Anja Torsvik, Heike Immervoll, Joerg Felsberg, Jan Brogger
Publikováno v:
Acta Neuropathologica
Acta neuropathologica, 122(4), 495-510. Springer Verlag
Acta Neuropathologica, 122(4), 495-510. Springer Verlag
Acta neuropathologica, 122(4), 495-510. Springer Verlag
Acta Neuropathologica, 122(4), 495-510. Springer Verlag
Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer cells with an immature stem-l
Autor:
Nicolaas H. C. Brons, Jacques Zimmer, Aurélie Poli, Martha Chekenya, Wim Ammerlaan, François Hentges, Tatiana Michel
Publikováno v:
Immunology. 131:386-394
Natural killer (NK) cells are important effectors of both innate and adaptive immune responses. Although human and mouse NK cells are extensively characterized, much less is known about the rat cells, partly because of the current lack of reliable is