Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Nicola Z. Hobbs"'
Progressive alterations in white matter microstructure across the timecourse of Huntington's disease
Autor:
Carlos Estevez‐Fraga, Michael S. Elmalem, Marina Papoutsi, Alexandra Durr, Elin M. Rees, Nicola Z. Hobbs, Raymund A. C. Roos, Bernhard Landwehrmeyer, Blair R. Leavitt, Douglas R. Langbehn, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi, Sarah Gregory
Publikováno v:
Brain and Behavior, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecou
Externí odkaz:
https://doaj.org/article/14760f7b295f464cbc8b231b3d170168
Validating Automated Segmentation Tools in the Assessment of Caudate Atrophy in Huntington’s Disease
Autor:
Nina M. Mansoor, Tishok Vanniyasingam, Ian Malone, Nicola Z. Hobbs, Elin Rees, Alexandra Durr, Raymund A. C. Roos, Bernhard Landwehrmeyer, Sarah J. Tabrizi, Eileanoir B. Johnson, Rachael I. Scahill
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Neuroimaging shows considerable promise in generating sensitive and objective outcome measures for therapeutic trials across a range of neurodegenerative conditions. For volumetric measures the current gold standard is manual delineation,
Externí odkaz:
https://doaj.org/article/026f447a265141ffb249f5f1aaf36811
Autor:
null Carlos Estevez‐Fraga, null Michael S. Elmalem, null Marina Papoutsi, null Alexandra Durr, null Elin M. Rees, null Nicola Z. Hobbs, null Raymund A. C. Roos, null Bernhard Landwehrmeyer, null Blair R. Leavitt, null Douglas R. Langbehn, null Rachael I. Scahill, null Geraint Rees, null Sarah J. Tabrizi, null Sarah Gregory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14bc68627b3897b4161c7070f737513f
https://doi.org/10.1002/brb3.2940/v2/response1
https://doi.org/10.1002/brb3.2940/v2/response1
Autor:
Annabelle Coleman, Mackenzie T Langan, Gaurav Verma, Harry Knights, Rachelle Dar Santos, Allison Coleman, Aaron Sturrock, Blair R Leavitt, Sarah J Tabrizi, Rachael I Scahill, Nicola Z Hobbs
Publikováno v:
E: Imaging.
Validating automated segmentation tools in the assessment of caudate atrophy in Huntington's disease
Autor:
Nicola Z. Hobbs, Alexandra Durr, Bernhard Landwehrmeyer, Raymund A.C. Roos, Nina M. Mansoor, Sarah J. Tabrizi, Eileanoir B. Johnson, Tishok Vanniyasingam, Elin M. Rees, Rachael I. Scahill, Ian B. Malone
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Frontiers in Neurology
Frontiers in Neurology, 12. FRONTIERS MEDIA SA
Frontiers in Neurology, Frontiers, 2021, 12, pp.616272. ⟨10.3389/fneur.2021.616272⟩
Frontiers in Neurology, 2021, 12, pp.616272. ⟨10.3389/fneur.2021.616272⟩
Frontiers in Neurology
Frontiers in Neurology, 12. FRONTIERS MEDIA SA
Frontiers in Neurology, Frontiers, 2021, 12, pp.616272. ⟨10.3389/fneur.2021.616272⟩
Frontiers in Neurology, 2021, 12, pp.616272. ⟨10.3389/fneur.2021.616272⟩
Background: Neuroimaging shows considerable promise in generating sensitive and objective outcome measures for therapeutic trials across a range of neurodegenerative conditions. For volumetric measures the current gold standard is manual delineation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c85349840e033015de806d312ee21a
https://doi.org/10.3389/fneur.2021.616272
https://doi.org/10.3389/fneur.2021.616272
Autor:
Filipe B, Rodrigues, Lauren M, Byrne, Enrico, De Vita, Eileanoir B, Johnson, Nicola Z, Hobbs, John S, Thornton, Rachael I, Scahill, Edward J, Wild
Publikováno v:
The European Journal of Neuroscience
Multiple targeted therapeutics for Huntington's disease are now in clinical trials, including intrathecally delivered compounds. Previous research suggests that CSF dynamics may be altered in Huntington's disease, which could be of paramount relevanc
Autor:
Lauren M. Byrne, Filipe B. Rodrigues, Edward J. Wild, Rachael I. Scahill, John S. Thornton, Eileanoir B. Johnson, Enrico De Vita, Nicola Z. Hobbs
Publikováno v:
Imaging.
Background The dynamics of cerebrospinal fluid (CSF) flow have never been studied in Huntington’s disease (HD), and could have a clinically significant impact on the expected distribution of central nervous system delivered drugs such as huntingtin
Autor:
Nicola Z. Hobbs, Alexandra Durr, Bernhard Landwehrmeyer, James H. Cole, Elin M. Rees, Salman Haider, Sarah J. Tabrizi, Ruth Farmer, Rachael I. Scahill
Publikováno v:
Movement Disorders. 29:1648-1654
The cerebellum has received limited attention in Huntington's disease (HD), despite signs of possible cerebellar dysfunction, including motor incoordination and impaired gait, which are currently attributed to basal ganglia atrophy and disrupted fron
Autor:
Nicola Z. Hobbs, Rachael I. Scahill, Alexandra Durr, Sarah J. Tabrizi, HE Crawford, Raymund A.C. Roos, James H. Cole, Ian B. Malone, Bernhard Landwehrmeyer, Chris Frost, Elin M. Rees, Reiner Sprengelmeyer, Ruth Farmer
Publikováno v:
NeuroImage: Clinical; Vol 2
NeuroImage : Clinical
Neuroimage-Clinical
Neuroimage-Clinical, Elsevier, 2013, 2, pp.204-211. ⟨10.1016/j.nicl.2012.12.001⟩
Neuroimage-Clinical, 2013, 2, pp.204-211. ⟨10.1016/j.nicl.2012.12.001⟩
NeuroImage: Clinical
NeuroImage : Clinical
Neuroimage-Clinical
Neuroimage-Clinical, Elsevier, 2013, 2, pp.204-211. ⟨10.1016/j.nicl.2012.12.001⟩
Neuroimage-Clinical, 2013, 2, pp.204-211. ⟨10.1016/j.nicl.2012.12.001⟩
NeuroImage: Clinical
Background Macro- and micro-structural neuroimaging measures provide valuable information on the pathophysiology of Huntington's disease (HD) and are proposed as biomarkers. Despite theoretical advantages of microstructural measures in terms of sensi
Publikováno v:
Journal of Huntington's Disease. 2:21-39
Identifying markers able to characterise the progression of Huntington's Disease (HD) is of great importance to the HD research community, as such markers may provide valuable outcome measures in future clinical trials. Neuroimaging measures are obvi