Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicola Thatcher"'
Publikováno v:
Journal of Neurochemistry. 72:2471-2478
Under control conditions, superfused hippocampal slices exhibited a significantly higher phosphocreatine (PCr)/ATP ratio than cortical slices; the evidence suggests that this is due to lower concentrations of ATP, rather than higher concentrations of
Autor:
Andrew M. Taylor, Mary A. McLean, O. Ben-Yoseph, Nicola Thatcher, Malcolm Prior, H. S. Bachelard, R.S. Badar-Goffer, Peter G. Morris
Publikováno v:
Neurochemical Research. 27:51-58
Exposure of guinea pig brain slices to low concentrations (10 μM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher con
Publikováno v:
Scopus-Elsevier
We are applying multi-nuclear high-field (500 MHz) MR spectroscopy of metabolising whole tissue preparations of the mammalian brain to studies on individual components of convulsions, which include prolonged depolarization, metabolic deprivation, and
Autor:
Anderew Taylor, Nicola Thatcher, H. S. Bachelard, Oded Ben-Yoseph, Ronnitte Badar-Goffer, Peter Morris
Publikováno v:
Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine. 2:285-289
13C from labeled glucose is normally incorporated rapidly into cerebral glutamate with little detectable glutamine or citrate. In contrast, glutamine and citrate only show significant labeling from13C acetate, which reflects metabolism in glial cells
Publikováno v:
Neurochemical research. 30(10)
We have investigated in more detail our previous observations on a form of ischaemic pre-conditioning “metabolic adaptation”, i.e.—that sequential metabolic insults (hypoxia followed 40 min later by combined hypoxia + hypoglycaemia, or vice ver
Publikováno v:
Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine. 2:433-435
The19F-NMR calcium indicator 5FBAPTA has been used to measure changes in free intracellular calcium, [Ca2+],, in superfused guinea pig cerebral cortical slices. Increases in [Ca2+], have been observed with depolarization and the combined insult of hy
Autor:
Artur Klimaszewski, J Tyson Tildon, Kor Venema, Raymond Boatright, N. Westergaard, Wolfram Hemmer, Orla M. Larsson, Theo Wallimann, Naichen Yu, Shirley Huang, Albert Okken, Guy K. Bryan, G. Unsgård, Niels Westergaard, Marc Yudkoff, David E Pleasure, T. Wallimann, Olivier Sorg, Patricia Manos, John C. Lehmann, F. Fonnum, A.-L. Veuthey, James G. McCormack, Richard P. Shank, Carol L. Zielke, M. Tsacopoulos, A. Brand, T.B. Müller, Louis Sokoloff, Richard M. Denton, Luc Pellerin, Patricia Lund, David Nelson, Jean-Luc Martin, D. Holtzman, Itzhak Nissim, Liang Peng, James C. K. Lai, H. Ronald Zielke, Rienk Baarsma, Peter Morris, Kevin L. Behar, Mary C. McKenna, Arne Schousboe, M. Tsuji, Ursula Sonnewald, Gregory C. Leo, L. Hertz, A. Schousboe, Pierre J. Magistretti, Roger F. Butterworth, Steffen B. Petersen, Nicola Thatcher, Joseph H. Stevenson, Maria Erecińska, S.B. Petersen, U. Sonnewald, Z.-P. Lin, I. Alick Paterson, Denis Kapkov, Rong Huang, R. S. Badar-Goffer, Dermot H. Williamson, Yevgeny Daikhin, Bernard F. Driscoll, Jakob Korf, T. Cullingford, B. Hassel, John Edmond, J.M. Land, Elaine E. Kaufman, Herman S. Bachelard, T.E. Bates, W. Hemmer, Leif Hertz, J.B. Clark, D. Leibfritz, David M. Holtzman, Jaep de Boer, Wolfgang Walz, Oded Ben-Yoseph, C. Richter-Landsberg, Yinyin Huang, Tyson Tildon
Publikováno v:
Developmental Neuroscience. 15:378-380
Publikováno v:
Journal of neurochemistry. 62(6)
(1) The effects of glutamate and NMDA on the free intracellular calcium concentration ([Ca2+]i) have been followed in superfused cortical slices using the 19F-magnetic resonance indicator 1,2-bis(2-amino-5-fluorophenoxy)ethane-N,N,N',N'-tetraacetic a
Publikováno v:
Journal of neurochemistry. 61(6)
(1) The energy state and free intracellular calcium concentration ([Ca2+]i) of superfused cortical slices were measured in moderate hypoxia (approximately 65 microM O2), in mild hypoglycaemia (0.5 mM glucose), and in combinations of the two insults u
Publikováno v:
Scopus-Elsevier
The effects of hypoxia and hypoglycaemia on cerebral metabolism and calcium have been studied using multinuclear magnetic resonance spectroscopy. 13C MRS showed that severe hypoxia did not cause any further increase in metabolic flux into lactate see