Výsledky vyhledávání - "Nicola Stock"

Akademický článek

Physical and Psychosocial Benefits of Sports Participation Among Children and Adolescents with Chronic Diseases: A Systematic Review

Autor: Borja Sañudo, Antonio Jesús Sánchez-Oliver, Jesús Fernández-Gavira, Dominik Gaser, Nicola Stöcker, Miguel Peralta, Adilson Marques, Sofia Papakonstantinou, Chiara Nicolini, Christina Sitzberger

Publikováno v: Sports Medicine - Open, Vol 10, Iss 1, Pp 1-28 (2024)

Abstract Background This study aims to identify sports interventions for children and adolescents (CaA) with chronic diseases and evaluate their impact on physical, psychological, and social well-being. The findings of this study will contribute to o

Externí odkaz: https://doaj.org/article/a68d6a1c177e48238a5c7ba53864c850

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An Acceptance and Commitment Therapy Prototype Mobile Program for Individuals With a Visible Difference: Mixed Methods Feasibility Study

Autor: Fabio, Zucchelli, Olivia, Donnelly, Emma, Rush, Paul, White, Holly, Gwyther, Heidi, Williamson, Nicola, Stock

Publikováno v: JMIR Formative Research. 6:e33449

Background Mobile apps may offer a valuable platform for delivering evidence-based psychological interventions for individuals with atypical appearances, or visible differences, who experience psychosocial appearance concerns such as appearance-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539b41190d2dd5dcc2f777e154cf8cda
https://doi.org/10.2196/33449

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mda-5, but not RIG-I, is a common target for paramyxovirus V proteins

Autor: Michael A. Skinner, Stephen Goodbourn, Craig Ross, Kay Childs, Nicola Stock, Louise Hilton, J. Andrejeva, Richard E. Randall

Publikováno v: Virology. 359(1):190-200

The induction of IFN-beta by the paramyxovirus PIV5 (formerly known as SV5) is limited by the action of the viral V protein that targets the cellular RNA helicase mda-5. Here we show that 12 other paramyxoviruses also target mda-5 by a direct interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b88e915a495fd32a8ff976336622ed

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Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs

Autor: Nicola Stock, Steve Goodbourn, B. Precious, Kathrin Hagmaier, Lin-Fa Wang, Richard E. Randall, Kay Childs

Publikováno v: The Journal of General Virology

Mapuera virus(MPRV) is a paramyxovirus that was originally isolated from bats, but its host range remains unknown. It was classified as a member of the genusRubulaviruson the basis of structural and genetic features. Like other rubulaviruses it encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a27bd3f3c2d7567c60e477139cc214
http://europepmc.org/articles/PMC2884952

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A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species

Autor: Kathrin Hagmaier, Nicola Stock, Steve Goodbourn, Richard E. Randall, Lin-Fa Wang

Publikováno v: The Journal of General Virology

The V protein of the paramyxovirus Nipah virus (NiV) has been shown to antagonize the interferon (IFN) response in human cells via sequestration of STAT1 and STAT2. This study describes a mutant of the NiV V protein, referred to as V(AAHL), that is u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417524df636d2d0e64cdb67f19974054
https://doi.org/10.1099/vir.0.82261-0

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Relationships and host range of human, canine, simian and porcine isolates of simian virus 5 (parainfluenza virus 5)

Autor: Nicola Stock, D. F. Young, Nikolaos Chatziandreou, Kathrin Hagmaier, Richard E. Randall, Duncan J. McGeoch, J. Andrejeva

Publikováno v: Journal of General Virology. 85:3007-3016

Sequence comparison of the V/P and F genes of 13 human, canine, porcine and simian isolates of simian virus 5 (SV5) revealed a surprising lack of sequence variation at both the nucleotide and amino acid levels (0–3 %), even though the viruses were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdf3474ef93730cf71a3469be086e1c
https://doi.org/10.1099/vir.0.80200-0

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The Anti-Interferon Mechanisms of Paramyxoviruses

Autor: Stephen Goodbourn, Richard E. Randall, Nicola Stock

Publikováno v: Modulation of Host Gene Expression and Innate Immunity by Viruses ISBN: 1402032412

Although viruses from all genera within the Paramyxoviridae family antagonize the IFN response, there are a wide variety of mechanisms by which this antagonism occurs. It appears that viruses from both sub-families suppress the production of IFN via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46a6a96de1fd4d4bcb843c3cea86ad75
https://doi.org/10.1007/1-4020-3242-0_6

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The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

Autor: J. Andrejeva, Richard E. Randall, Dan F. Young, T.S. Carlos, Nicola Stock, Steve Goodbourn, Kay Childs

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 101(49)

Most paramyxoviruses circumvent the IFN response by blocking IFN signaling and limiting the production of IFN by virus-infected cells. Here we report that the highly conserved cysteine-rich C-terminal domain of the V proteins of a wide variety of par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7deec1fed5b2e2799df9d8a4f13830
https://pubmed.ncbi.nlm.nih.gov/15563593

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